YU22903A - 17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja - Google Patents
17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenjaInfo
- Publication number
- YU22903A YU22903A YU22903A YUP22903A YU22903A YU 22903 A YU22903 A YU 22903A YU 22903 A YU22903 A YU 22903A YU P22903 A YUP22903 A YU P22903A YU 22903 A YU22903 A YU 22903A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- producing
- same
- alpha
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0073—Sulfur-containing hetero ring
- C07J71/0078—Sulfur-containing hetero ring containing only sulfur
- C07J71/0084—Episulfides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Pronalazak se odnosi na 17α-fluoroalkil steoride opšte formule (I), STEROID (I), pri čemu R3 predstavlja grupu sa formulom CnFmHo, gde je n = 1, 2, 3, 4, 5, ili 6, m > 1 i m+o = 2n + 1. Pronalazak se dalje odnosi na postupke za proizvodnju istih i na sastave koji sadrže navedena jedinjenja. Pronalazački sastav opšte formule (I) poseduje androgenu aktivnost.[The invention relates to 17α fluoroalkyl steroids of the general formula (I), STEROID (I), wherein R3 represents a group of the formula CnFmHo, wherein n = 1, 2, 3, 4, 5 or 6, m > 1 and m+o = 2n+1. The invention further relates to methods for producing the same and to compositions that contain said compounds. The inventive composition of the general formula (I) possess androgenic activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10049736A DE10049736A1 (de) | 2000-09-29 | 2000-09-29 | 17alpha-Fluoralkylsteroide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
Publication Number | Publication Date |
---|---|
YU22903A true YU22903A (sh) | 2006-03-03 |
Family
ID=7659018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU22903A YU22903A (sh) | 2000-09-29 | 2001-09-28 | 17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja |
Country Status (29)
Country | Link |
---|---|
US (1) | US20040024231A1 (sh) |
EP (1) | EP1322660B1 (sh) |
JP (1) | JP2004509971A (sh) |
KR (1) | KR20030061815A (sh) |
CN (1) | CN1305890C (sh) |
AT (1) | ATE338054T1 (sh) |
AU (1) | AU1382202A (sh) |
BG (1) | BG107763A (sh) |
BR (1) | BR0114258A (sh) |
CA (1) | CA2422056A1 (sh) |
DE (2) | DE10049736A1 (sh) |
DK (1) | DK1322660T3 (sh) |
EA (1) | EA005772B1 (sh) |
EE (1) | EE200300124A (sh) |
ES (1) | ES2272550T3 (sh) |
HK (1) | HK1061860A1 (sh) |
HR (1) | HRP20030334A2 (sh) |
HU (1) | HUP0301198A2 (sh) |
IL (2) | IL154828A0 (sh) |
MX (1) | MXPA03002606A (sh) |
NO (1) | NO325058B1 (sh) |
NZ (1) | NZ524781A (sh) |
PL (1) | PL361666A1 (sh) |
PT (1) | PT1322660E (sh) |
SK (1) | SK5192003A3 (sh) |
UA (1) | UA76125C2 (sh) |
WO (1) | WO2002026759A2 (sh) |
YU (1) | YU22903A (sh) |
ZA (1) | ZA200303216B (sh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
US20050182322A1 (en) * | 2004-02-17 | 2005-08-18 | Liebel-Flarsheim Company | Injector auto purge |
EP1854465A1 (en) * | 2006-05-12 | 2007-11-14 | Alexander Tobias Teichmann | Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers |
DE102006054535A1 (de) * | 2006-11-15 | 2008-05-21 | Bayer Schering Pharma Aktiengesellschaft | Progesteronrezeptorantagonisten |
KR101044794B1 (ko) * | 2011-01-05 | 2011-06-27 | 연규백 | 복합판넬에 브이 홈을 컷팅하는 장치 |
CN102964411B (zh) * | 2012-12-03 | 2015-04-22 | 华中药业股份有限公司 | 一种雄甾-4,6-二烯-17α-甲基-17β-醇-3-酮的合成方法 |
CN114409717B (zh) * | 2021-12-17 | 2023-03-17 | 湖南科益新生物医药有限公司 | 替勃龙中间体醚化物和替勃龙的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3029261A (en) * | 1959-11-30 | 1962-04-10 | Syntex Sa | Steroidal fluoro compounds and process for the production thereof |
US3046273A (en) * | 1961-01-18 | 1962-07-24 | Merck & Co Inc | Novel 17alpha-trifluoro-propynyl androstenes and processes |
US3255182A (en) * | 1961-02-13 | 1966-06-07 | Merck & Co Inc | 17alpha-haloethynyl-[3, 2-c]pyrazolo androstenes and intermediates therefor |
CH431508A (de) * | 1961-06-16 | 1967-03-15 | Ciba Geigy | Verfahren zur Ketalisierung der 3-Oxogruppe in 5(10)-3-Oxo-19-nor-steroiden |
US3098851A (en) * | 1961-11-20 | 1963-07-23 | Searle & Co | 17alpha-alkynyl-2beta-halo-5alpha-androstane-3alpha, 17beta-diols, esters thereof, and intermediates thereto |
US3092623A (en) * | 1961-12-01 | 1963-06-04 | Merck & Co Inc | [3, 2-c] pyrazolo-4, 9-androstadienes |
US3076825A (en) * | 1962-02-14 | 1963-02-05 | Syntex Corp | 17alpha-(1'-fluoroethyl) and 17alpha-(1', 1'-difluoroethyl) androstane derivatives and process therefor |
US3340251A (en) * | 1965-10-18 | 1967-09-05 | Merck & Co Inc | 17beta-hydroxy-17alpha-halohydrocarbon-19-nor-androst-4-ene-3-ones and the delta5(10)-isomers thereof |
AU3257993A (en) * | 1991-12-22 | 1993-07-28 | Schering Aktiengesellschaft | 3-methylsulphonylhydrazono and 3-oxyimino steroids, a method of preparing them, pharmaceutical preparations containing them and their use in the preparation of drugs |
CN1072678C (zh) * | 1994-05-30 | 2001-10-10 | 中国科学院上海有机化学研究所 | 三氟甲基甾体化合物、制备及其用途 |
DE19706061A1 (de) * | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
DE19860719A1 (de) * | 1998-12-23 | 2000-06-29 | Schering Ag | Neue Testosteronderivate und ihre Verwendung zur Langzeittherapie von Androgen-abhängigen Erkrankungen |
DE10221034A1 (de) * | 2002-05-03 | 2003-11-20 | Schering Ag | 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
-
2000
- 2000-09-29 DE DE10049736A patent/DE10049736A1/de not_active Withdrawn
-
2001
- 2001-09-28 CN CNB018165494A patent/CN1305890C/zh not_active Expired - Fee Related
- 2001-09-28 US US10/381,789 patent/US20040024231A1/en not_active Abandoned
- 2001-09-28 EP EP01982167A patent/EP1322660B1/de not_active Expired - Lifetime
- 2001-09-28 NZ NZ524781A patent/NZ524781A/en unknown
- 2001-09-28 KR KR10-2003-7004483A patent/KR20030061815A/ko active IP Right Grant
- 2001-09-28 CA CA002422056A patent/CA2422056A1/en not_active Abandoned
- 2001-09-28 BR BR0114258-5A patent/BR0114258A/pt not_active IP Right Cessation
- 2001-09-28 WO PCT/DE2001/003732 patent/WO2002026759A2/de active IP Right Grant
- 2001-09-28 JP JP2002531142A patent/JP2004509971A/ja active Pending
- 2001-09-28 ES ES01982167T patent/ES2272550T3/es not_active Expired - Lifetime
- 2001-09-28 YU YU22903A patent/YU22903A/sh unknown
- 2001-09-28 DK DK01982167T patent/DK1322660T3/da active
- 2001-09-28 SK SK519-2003A patent/SK5192003A3/sk unknown
- 2001-09-28 IL IL15482801A patent/IL154828A0/xx active IP Right Grant
- 2001-09-28 DE DE50110892T patent/DE50110892D1/de not_active Expired - Fee Related
- 2001-09-28 PL PL01361666A patent/PL361666A1/xx unknown
- 2001-09-28 AU AU1382202A patent/AU1382202A/xx not_active Withdrawn
- 2001-09-28 UA UA2003043904A patent/UA76125C2/uk unknown
- 2001-09-28 EA EA200300400A patent/EA005772B1/ru not_active IP Right Cessation
- 2001-09-28 EE EEP200300124A patent/EE200300124A/xx unknown
- 2001-09-28 AT AT01982167T patent/ATE338054T1/de not_active IP Right Cessation
- 2001-09-28 MX MXPA03002606A patent/MXPA03002606A/es active IP Right Grant
- 2001-09-28 HU HU0301198A patent/HUP0301198A2/hu unknown
- 2001-09-28 PT PT01982167T patent/PT1322660E/pt unknown
-
2003
- 2003-03-10 IL IL154828A patent/IL154828A/en not_active IP Right Cessation
- 2003-03-28 NO NO20031444A patent/NO325058B1/no unknown
- 2003-04-24 ZA ZA200303216A patent/ZA200303216B/en unknown
- 2003-04-25 BG BG107763A patent/BG107763A/bg unknown
- 2003-04-28 HR HR20030334A patent/HRP20030334A2/hr not_active Application Discontinuation
-
2004
- 2004-07-06 HK HK04104883A patent/HK1061860A1/xx not_active IP Right Cessation
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