ATE277015T1 - Verfahren zur herstellung von 1,4-dihydropyridine sowie in diesem verfahren verwendete verbindungen - Google Patents
Verfahren zur herstellung von 1,4-dihydropyridine sowie in diesem verfahren verwendete verbindungenInfo
- Publication number
- ATE277015T1 ATE277015T1 AT98955389T AT98955389T ATE277015T1 AT E277015 T1 ATE277015 T1 AT E277015T1 AT 98955389 T AT98955389 T AT 98955389T AT 98955389 T AT98955389 T AT 98955389T AT E277015 T1 ATE277015 T1 AT E277015T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- aralkyl
- cycloalkyl
- alkyl
- iii
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK129997 | 1997-11-14 | ||
| PCT/DK1998/000492 WO1999025688A1 (en) | 1997-11-14 | 1998-11-13 | Process for the preparation of 1,4-dihydropyridines and compounds used in this process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277015T1 true ATE277015T1 (de) | 2004-10-15 |
Family
ID=8103308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98955389T ATE277015T1 (de) | 1997-11-14 | 1998-11-13 | Verfahren zur herstellung von 1,4-dihydropyridine sowie in diesem verfahren verwendete verbindungen |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1030841B1 (de) |
| AT (1) | ATE277015T1 (de) |
| AU (1) | AU1224799A (de) |
| DK (1) | DK1030841T3 (de) |
| ES (1) | ES2226185T3 (de) |
| HU (1) | HUP0100640A3 (de) |
| NO (1) | NO314900B1 (de) |
| PT (1) | PT1030841E (de) |
| RS (1) | RS49711B (de) |
| WO (1) | WO1999025688A1 (de) |
| ZA (1) | ZA9810320B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0116554A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão |
| WO2002053538A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| GB2371862B (en) | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| BR0116552A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Hemi-maleato de amlodipina, processo, método para o tratamento ou prevenção de angina ou hipertensão, composição farmacêutica, para uso no tratamento e/ou de angina ou da hipertensão |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| AP2003002820A0 (en) * | 2000-12-29 | 2003-06-30 | Pfizer Ltd | "Process for making amlodipine maleate" |
| BR0116553A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| ES2211317B1 (es) * | 2002-11-18 | 2005-10-16 | Finaf 92, S.A. | Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes. |
| CN103922996B (zh) * | 2013-01-11 | 2019-01-04 | 广东东阳光药业有限公司 | 一种药物新型中间体及其制备方法 |
| CN114989072B (zh) * | 2022-05-27 | 2023-07-21 | 四川大学 | 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| JPS6191185A (ja) * | 1984-10-11 | 1986-05-09 | Sumitomo Seiyaku Kk | 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体 |
| EP0225175A3 (de) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| NZ280378A (en) * | 1995-11-01 | 1998-04-27 | Apotex Inc | 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds |
-
1998
- 1998-11-11 ZA ZA9810320A patent/ZA9810320B/xx unknown
- 1998-11-13 PT PT98955389T patent/PT1030841E/pt unknown
- 1998-11-13 AU AU12247/99A patent/AU1224799A/en not_active Abandoned
- 1998-11-13 AT AT98955389T patent/ATE277015T1/de not_active IP Right Cessation
- 1998-11-13 ES ES98955389T patent/ES2226185T3/es not_active Expired - Lifetime
- 1998-11-13 RS YUP-285/00A patent/RS49711B/sr unknown
- 1998-11-13 HU HU0100640A patent/HUP0100640A3/hu unknown
- 1998-11-13 DK DK98955389T patent/DK1030841T3/da active
- 1998-11-13 EP EP98955389A patent/EP1030841B1/de not_active Expired - Lifetime
- 1998-11-13 WO PCT/DK1998/000492 patent/WO1999025688A1/en not_active Ceased
-
2000
- 2000-05-12 NO NO20002490A patent/NO314900B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20002490D0 (no) | 2000-05-12 |
| NO20002490L (no) | 2000-07-13 |
| EP1030841B1 (de) | 2004-09-22 |
| YU28500A (sh) | 2002-10-18 |
| ES2226185T3 (es) | 2005-03-16 |
| RS49711B (sr) | 2007-12-31 |
| NO314900B1 (no) | 2003-06-10 |
| DK1030841T3 (da) | 2005-01-24 |
| WO1999025688A1 (en) | 1999-05-27 |
| PT1030841E (pt) | 2005-01-31 |
| HUP0100640A2 (hu) | 2001-07-30 |
| EP1030841A1 (de) | 2000-08-30 |
| ZA9810320B (en) | 2000-05-11 |
| HUP0100640A3 (en) | 2001-11-28 |
| AU1224799A (en) | 1999-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1030841 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |