YU28500A - Postupak za dobivanje 1,4-dihidropiridina i jedinjenja koja se primenjuju u tom postupku - Google Patents

Postupak za dobivanje 1,4-dihidropiridina i jedinjenja koja se primenjuju u tom postupku

Info

Publication number
YU28500A
YU28500A YU28500A YU28500A YU28500A YU 28500 A YU28500 A YU 28500A YU 28500 A YU28500 A YU 28500A YU 28500 A YU28500 A YU 28500A YU 28500 A YU28500 A YU 28500A
Authority
YU
Yugoslavia
Prior art keywords
formula
aralkyl
cycloalkyl
alkyl
iii
Prior art date
Application number
YU28500A
Other languages
English (en)
Inventor
Gunar Leo Karup
Herbert Fritz Praikschat
Soren Bols Pedersen
Original Assignee
A/S Gea Farmaceutisk Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8103308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU28500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by A/S Gea Farmaceutisk Fabrik filed Critical A/S Gea Farmaceutisk Fabrik
Publication of YU28500A publication Critical patent/YU28500A/sh
Publication of RS49711B publication Critical patent/RS49711B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Opisani su postupak za dobivanje 1,4-dihidropiridina opste formule (I) ili njihiovih kiselinskih adicionih soli, naznacen time, sto obuhvata stupnjeve reagovanja acetala opste formule (II) sa R5ONH2 ili njegovom kiselinskom soli, tako da se dobiva oksim opste formule (III), u kojoj R1 svaki, nezavisno jedan od drugog, oznacava H, Cl ili CF3, R2 oznacava H, C1-C5-alkil, C3-C6-cikloalkil ili aralkil, n j 1 ili 2, R3 i R4, koji mogu biti isti ili razliciti, oznacavaju C1-C5-alkil, C3-C6-cikloalkil, aralkil ili zajedno predstavljaju -(CH2)m-, pri cemu je m jednako 2 ili 3, i R5 oznacava H, C1-C5-alkil, C3-C5-cikloalkil ili aralkil, i redukovanje formiranog oksima formule (III) tako da se dobije 1,4-dihidropiridin formule (I), i, ako se to zeli, pretvaranje jedinjenja formule (I) dobivenog u obliku slobodne baze u njegovu farmaceutski prihvatljivu kiselinsku adicionu so ili obrnuto (vice versa), i novi intermedijeri gformula (II) i (III).
YUP-285/00A 1997-11-14 1998-11-13 Postupak za dobijanje 1,4- dihidropiridina i jedinjenja koja se primenjuju u tom postupku RS49711B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK129997 1997-11-14

Publications (2)

Publication Number Publication Date
YU28500A true YU28500A (sh) 2002-10-18
RS49711B RS49711B (sr) 2007-12-31

Family

ID=8103308

Country Status (11)

Country Link
EP (1) EP1030841B1 (sh)
AT (1) ATE277015T1 (sh)
AU (1) AU1224799A (sh)
DK (1) DK1030841T3 (sh)
ES (1) ES2226185T3 (sh)
HU (1) HUP0100640A3 (sh)
NO (1) NO314900B1 (sh)
PT (1) PT1030841E (sh)
RS (1) RS49711B (sh)
WO (1) WO1999025688A1 (sh)
ZA (1) ZA9810320B (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
EP1309556B1 (en) 2000-12-29 2004-11-24 Pfizer Limited Amlodipine fumarate
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
GB2371862B (en) 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
WO2002053541A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
BR0116557A (pt) * 2000-12-29 2003-10-28 Pfizer Ltd Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
EP1309557B9 (en) 2000-12-29 2006-11-15 Pfizer Limited Amlodipine hemimaleate
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
ES2211317B1 (es) * 2002-11-18 2005-10-16 Finaf 92, S.A. Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
CN103922996B (zh) * 2013-01-11 2019-01-04 广东东阳光药业有限公司 一种药物新型中间体及其制备方法
CN114989072B (zh) * 2022-05-27 2023-07-21 四川大学 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
JPS6191185A (ja) * 1984-10-11 1986-05-09 Sumitomo Seiyaku Kk 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof
NZ280378A (en) * 1995-11-01 1998-04-27 Apotex Inc 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds

Also Published As

Publication number Publication date
NO314900B1 (no) 2003-06-10
RS49711B (sr) 2007-12-31
EP1030841B1 (en) 2004-09-22
HUP0100640A3 (en) 2001-11-28
HUP0100640A2 (hu) 2001-07-30
DK1030841T3 (da) 2005-01-24
ES2226185T3 (es) 2005-03-16
EP1030841A1 (en) 2000-08-30
AU1224799A (en) 1999-06-07
WO1999025688A1 (en) 1999-05-27
ATE277015T1 (de) 2004-10-15
NO20002490D0 (no) 2000-05-12
PT1030841E (pt) 2005-01-31
ZA9810320B (en) 2000-05-11
NO20002490L (no) 2000-07-13

Similar Documents

Publication Publication Date Title
DK0629609T3 (da) Fremgangsmåde til fremstilling af alkoxyiminoacetamidderivater og et mellemprodukt dertil
YU28500A (sh) Postupak za dobivanje 1,4-dihidropiridina i jedinjenja koja se primenjuju u tom postupku
CA2285891A1 (en) Triazole antifungal agents
CA2161542A1 (en) Novel 5-Pyrrolyl-2-Pyridylmethylsulfinyl Benzimidazole Derivatives
SU1279528A1 (ru) "cпocoб пoлучehия 1,4-дигидpoпиpидиhob или иx гидpoxлopидob"
WO2004000762A3 (en) Propionic acid derivatives and their use as hppars activators
ES8602783A1 (es) Un procedimiento para la preparacion de pirazolopiridinas.
PT87361A (pt) Process for preparing dihydropyridines
TW352383B (en) Hydroximic acid derivatives, processes for their preparation, and compositions comprising them
KR870002121A (ko) 디하이드로 피리딘 유도체의 제조방법
EP0357404A3 (en) Process for the preparation of cyclopentane derivatives
WO2000018722A3 (es) Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol
DK0832067T3 (da) Fremgangsmåde til omdannelse af 2,4-dichlorpyridiner til 2-aryloxy-4-chlorpyridiner
WO2002059089A3 (en) Process for the preparation of heterocyclic indene analogs
EP1227081A4 (en) PROCESS FOR THE PREPARATION OF OXYMINOALKANOIC ACID DERIVATIVES
EE200300090A (et) Asendatud imidasopüridiinühendite valmistamise meetod
ATE127449T1 (de) Anilinderivate und verfahren zu ihrer herstellung.
DK0391673T3 (da) Fremstilling af glutarsyrederivater
CA2345717A1 (en) Method for preparing trion-bis(oxime ether) derivatives andrion-mono and trion-bis(oxime ether) derivatives obtained therewith
DK0387946T3 (da) Fremgangsmåde til fremstilling af carbamater og mellemprodukter derved
JPS6429359A (en) 1,4-dihydropyridine derivative and production thereof
TR200402333T4 (tr) Artropodisidal karboksanilidler
CA2384925A1 (en) Process for the preparation of oxazole derivatives
MX9804820A (es) Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina.
ATE17000T1 (de) Substituierte azolylethyl-oximinoalkyl-ether, verfahren zu ihrer herstellung und ihre verwendung als fungizide.