RS49711B - Postupak za dobijanje 1,4- dihidropiridina i jedinjenja koja se primenjuju u tom postupku - Google Patents
Postupak za dobijanje 1,4- dihidropiridina i jedinjenja koja se primenjuju u tom postupkuInfo
- Publication number
- RS49711B RS49711B YUP-285/00A YU28500A RS49711B RS 49711 B RS49711 B RS 49711B YU 28500 A YU28500 A YU 28500A RS 49711 B RS49711 B RS 49711B
- Authority
- RS
- Serbia
- Prior art keywords
- formula
- aralkyl
- cycloalkyl
- alkyl
- acid addition
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Postupak za dobivanje 1,4-dihidropiridina opšte formule I u kojoj R1 svaki, nezavisno jedan od drugog, označava H, Cl ili CF3, R2 označava H, C1-C6-alkil, C3-C6-cikloalkil ili aralkil, a n je 1 ili 2, ili njihovih kiselinskih adicionih soli, naznačen time, što obuhvata stupnjeve reagvanja acetala opšte formule II dobivenog Hančovom sintezom izvodjenom uz primenu jedinjenja koje sadrži grupu formule IV kao jednog od reaktanata u Hančovoj kondenzaciji u kojim formulama II i IV R3 i R4, koji mogu biti isti ili različiti, označavaju C1-C5-alkil, C3-C6-cikloalkil, aralkil ili zajedno predstavljaju -(CH2)m-, pri čemu je m jednako 2 ili 3, a R1 i R2 i n imaju gore data značenja, sa R5ONH2 ili njegovom kiselinskom adicionom soli, pri čemu R5 označava H, C3-C5-alkil, C1-C6-cikloalkil ili aralkil, tako da se dobije oksim opšte formule III u kojoj R1, R2, R5 i n imaju gore data značenja, i redukovanja formiranog oksima formule III tako da se dobija 1,4-dihidropiridin formule I, i, ako se to želi, pretvaranja jedinjenja formule I dobivenog u obliku slobodne baze u njegovu farmaceutski prihvatljivu kiselinsku adicionu so ili vice versa.- Prijava sadrži još 8 patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK129997 | 1997-11-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU28500A YU28500A (sh) | 2002-10-18 |
| RS49711B true RS49711B (sr) | 2007-12-31 |
Family
ID=8103308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-285/00A RS49711B (sr) | 1997-11-14 | 1998-11-13 | Postupak za dobijanje 1,4- dihidropiridina i jedinjenja koja se primenjuju u tom postupku |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1030841B1 (sr) |
| AT (1) | ATE277015T1 (sr) |
| AU (1) | AU1224799A (sr) |
| DK (1) | DK1030841T3 (sr) |
| ES (1) | ES2226185T3 (sr) |
| HU (1) | HUP0100640A3 (sr) |
| NO (1) | NO314900B1 (sr) |
| PT (1) | PT1030841E (sr) |
| RS (1) | RS49711B (sr) |
| WO (1) | WO1999025688A1 (sr) |
| ZA (1) | ZA9810320B (sr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1309555T3 (da) * | 2000-12-29 | 2005-10-24 | Pfizer Ltd | Metode til fremstilling af amlodipinmaleat |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| WO2002054062A2 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| WO2002053538A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
| EP1309554A1 (en) | 2000-12-29 | 2003-05-14 | Synthon Licensing, Ltd. | Amide derivative of amlodipine |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| WO2002053539A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine hemimaleate |
| GB2372036B (en) | 2000-12-29 | 2004-05-19 | Bioorg Bv | Aspartate derivative of amlodipine |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| ES2211317B1 (es) * | 2002-11-18 | 2005-10-16 | Finaf 92, S.A. | Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes. |
| CN103922996B (zh) * | 2013-01-11 | 2019-01-04 | 广东东阳光药业有限公司 | 一种药物新型中间体及其制备方法 |
| CN114989072B (zh) * | 2022-05-27 | 2023-07-21 | 四川大学 | 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| JPS6191185A (ja) | 1984-10-11 | 1986-05-09 | Sumitomo Seiyaku Kk | 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体 |
| EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
| NZ280378A (en) * | 1995-11-01 | 1998-04-27 | Apotex Inc | 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds |
-
1998
- 1998-11-11 ZA ZA9810320A patent/ZA9810320B/xx unknown
- 1998-11-13 HU HU0100640A patent/HUP0100640A3/hu unknown
- 1998-11-13 DK DK98955389T patent/DK1030841T3/da active
- 1998-11-13 EP EP98955389A patent/EP1030841B1/en not_active Expired - Lifetime
- 1998-11-13 RS YUP-285/00A patent/RS49711B/sr unknown
- 1998-11-13 ES ES98955389T patent/ES2226185T3/es not_active Expired - Lifetime
- 1998-11-13 AT AT98955389T patent/ATE277015T1/de not_active IP Right Cessation
- 1998-11-13 AU AU12247/99A patent/AU1224799A/en not_active Abandoned
- 1998-11-13 WO PCT/DK1998/000492 patent/WO1999025688A1/en active IP Right Grant
- 1998-11-13 PT PT98955389T patent/PT1030841E/pt unknown
-
2000
- 2000-05-12 NO NO20002490A patent/NO314900B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999025688A1 (en) | 1999-05-27 |
| DK1030841T3 (da) | 2005-01-24 |
| HUP0100640A2 (hu) | 2001-07-30 |
| NO314900B1 (no) | 2003-06-10 |
| ATE277015T1 (de) | 2004-10-15 |
| NO20002490L (no) | 2000-07-13 |
| EP1030841B1 (en) | 2004-09-22 |
| HUP0100640A3 (en) | 2001-11-28 |
| ES2226185T3 (es) | 2005-03-16 |
| EP1030841A1 (en) | 2000-08-30 |
| AU1224799A (en) | 1999-06-07 |
| NO20002490D0 (no) | 2000-05-12 |
| ZA9810320B (en) | 2000-05-11 |
| PT1030841E (pt) | 2005-01-31 |
| YU28500A (sh) | 2002-10-18 |
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