BR0306643A - Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical - Google Patents

Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical

Info

Publication number
BR0306643A
BR0306643A BR0306643-6A BR0306643A BR0306643A BR 0306643 A BR0306643 A BR 0306643A BR 0306643 A BR0306643 A BR 0306643A BR 0306643 A BR0306643 A BR 0306643A
Authority
BR
Brazil
Prior art keywords
tiepine
inhibitors
compounds
bile acid
hydroxy alkyl
Prior art date
Application number
BR0306643-6A
Other languages
English (en)
Inventor
Kevin J Koeller
Samuel J Tremont
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0306643A publication Critical patent/BR0306643A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/04—Seven-membered rings not condensed with other rings

Abstract

"NOVOS COMPOSTOS HIDROXI ALQUIL/ARIL OU CETO TIEPINAS COMO INIBIDORES DO TRANSPORTE CO-DEPENDENTE DE áCIDO BILIAR - SóDIO APICAL". Inibidores de tiepina do transporte co-dependente de ácido biliar - sódio apical (ASBT) são revelados juntamente com métodos de obtenção dos mesmos, métodos de utilização dos mesmos para tratar as condições hiperlipidêmicas bem como composições farmacêuticas contendo os mesmos compostos.
BR0306643-6A 2002-01-17 2003-01-15 Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical BR0306643A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34860502P 2002-01-17 2002-01-17
PCT/US2003/000025 WO2003061604A2 (en) 2002-01-17 2003-01-15 Novel alkyl/aryl hydroxy or keto thiepines.

Publications (1)

Publication Number Publication Date
BR0306643A true BR0306643A (pt) 2004-10-19

Family

ID=27613232

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0306643-6A BR0306643A (pt) 2002-01-17 2003-01-15 Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical

Country Status (8)

Country Link
US (1) US6852753B2 (pt)
EP (1) EP1465885A4 (pt)
JP (1) JP2005521653A (pt)
AU (1) AU2003207431A1 (pt)
BR (1) BR0306643A (pt)
CA (1) CA2471639A1 (pt)
MX (1) MXPA04006255A (pt)
WO (1) WO2003061604A2 (pt)

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US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
JP2005518347A (ja) * 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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CN107375932B (zh) 2011-10-28 2021-12-21 夏尔人类遗传性治疗公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
EA029581B1 (ru) 2011-10-28 2018-04-30 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита
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Also Published As

Publication number Publication date
MXPA04006255A (es) 2004-09-27
WO2003061604A3 (en) 2004-01-08
JP2005521653A (ja) 2005-07-21
AU2003207431A1 (en) 2003-09-02
CA2471639A1 (en) 2003-07-31
US20030195218A1 (en) 2003-10-16
EP1465885A2 (en) 2004-10-13
US6852753B2 (en) 2005-02-08
WO2003061604A2 (en) 2003-07-31
EP1465885A4 (en) 2005-04-27

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B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]