BRPI0414111A - inibidores heterocìclicos de mek e métodos de uso dos mesmos - Google Patents
inibidores heterocìclicos de mek e métodos de uso dos mesmosInfo
- Publication number
- BRPI0414111A BRPI0414111A BRPI0414111-3A BRPI0414111A BRPI0414111A BR PI0414111 A BRPI0414111 A BR PI0414111A BR PI0414111 A BRPI0414111 A BR PI0414111A BR PI0414111 A BRPI0414111 A BR PI0414111A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- compounds
- heterocyclic
- mek inhibitors
- mek
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Abstract
"INIBIDORES HETEROCìCLICOS DE MEK E MéTODOS DE USO DOS MESMOS". A presente invenção refere-se a compostos da Fórmula (I) e seus sais e pró-drogas farmaceuticamente aceitáveis, onde R¬ 1¬, R¬ 2¬, R¬ 7¬, R¬ 8¬, R¬ 9¬ e R¬ 10¬, W e Y são definidos no relatório. Tais compostos são inibidores de MEK e úteis no tratamento de doenças hiperproliferativas, tal como câncer e inflamação em mamíferos. São também descritos métodos de uso de tais compostos no tratamento de doença hiperproliferativa em mamíferos e composições farmacêuticas contendo tais compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/654,580 US7144907B2 (en) | 2003-09-03 | 2003-09-03 | Heterocyclic inhibitors of MEK and methods of use thereof |
US10/929,295 US7230099B2 (en) | 2003-09-03 | 2004-08-30 | Heterocyclic inhibitors of MEK and methods of use thereof |
PCT/US2004/028649 WO2005023759A2 (en) | 2003-09-03 | 2004-09-01 | Heterocyclic inhibitors of mek and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414111A true BRPI0414111A (pt) | 2006-10-31 |
Family
ID=34218110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414111-3A BRPI0414111A (pt) | 2003-09-03 | 2004-09-01 | inibidores heterocìclicos de mek e métodos de uso dos mesmos |
Country Status (18)
Country | Link |
---|---|
US (5) | US7144907B2 (pt) |
EP (1) | EP1673339B1 (pt) |
JP (1) | JP4131741B2 (pt) |
KR (1) | KR20060070558A (pt) |
CN (1) | CN1874769A (pt) |
AR (1) | AR046081A1 (pt) |
AU (1) | AU2004270699B2 (pt) |
BR (1) | BRPI0414111A (pt) |
CA (1) | CA2537321A1 (pt) |
IL (4) | IL173936A (pt) |
IS (1) | IS8392A (pt) |
MX (1) | MXPA06002466A (pt) |
NO (1) | NO20061506L (pt) |
PT (1) | PT1673339E (pt) |
RU (1) | RU2006109599A (pt) |
TW (1) | TW200526607A (pt) |
WO (1) | WO2005023759A2 (pt) |
ZA (1) | ZA200602581B (pt) |
Cited By (4)
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WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
WO2011106298A1 (en) | 2010-02-25 | 2011-09-01 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
US11078540B2 (en) | 2010-03-09 | 2021-08-03 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
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UA76837C2 (uk) | 2002-03-13 | 2006-09-15 | Еррей Байофарма Інк. | N3 алкіловані похідні бензімідазолу як інгібітори мек |
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2003
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- 2004-09-01 WO PCT/US2004/028649 patent/WO2005023759A2/en active Application Filing
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
WO2011106298A1 (en) | 2010-02-25 | 2011-09-01 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
EP3028699A1 (en) | 2010-02-25 | 2016-06-08 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
US11078540B2 (en) | 2010-03-09 | 2021-08-03 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
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