BR112012008483A2 - combunações de um inibidor de pi3k e um inibidor de mex - Google Patents

combunações de um inibidor de pi3k e um inibidor de mex

Info

Publication number
BR112012008483A2
BR112012008483A2 BR112012008483A BR112012008483A BR112012008483A2 BR 112012008483 A2 BR112012008483 A2 BR 112012008483A2 BR 112012008483 A BR112012008483 A BR 112012008483A BR 112012008483 A BR112012008483 A BR 112012008483A BR 112012008483 A2 BR112012008483 A2 BR 112012008483A2
Authority
BR
Brazil
Prior art keywords
inhibitor
mex
combinations
pi3k
pi3k inhibitor
Prior art date
Application number
BR112012008483A
Other languages
English (en)
Inventor
T Chan Iris
Wallin Jeffrey
Prescott John
P Hoeflich Klaus
Friedman Lori
Belvin Marcia
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43072663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012008483(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112012008483A2 publication Critical patent/BR112012008483A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BR112012008483A 2009-10-12 2010-10-11 combunações de um inibidor de pi3k e um inibidor de mex BR112012008483A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25085209P 2009-10-12 2009-10-12
PCT/EP2010/065149 WO2011054620A1 (en) 2009-10-12 2010-10-11 Combinations of a pi3k inhibitor and a mek inhibitor

Publications (1)

Publication Number Publication Date
BR112012008483A2 true BR112012008483A2 (pt) 2019-09-24

Family

ID=43072663

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008483A BR112012008483A2 (pt) 2009-10-12 2010-10-11 combunações de um inibidor de pi3k e um inibidor de mex

Country Status (24)

Country Link
US (1) US20110086837A1 (pt)
EP (1) EP2488178B1 (pt)
JP (2) JP2013507415A (pt)
KR (1) KR101489045B1 (pt)
CN (1) CN102740851B (pt)
AR (1) AR078588A1 (pt)
AU (1) AU2010314287A1 (pt)
BR (1) BR112012008483A2 (pt)
CA (1) CA2776944A1 (pt)
CL (1) CL2012000913A1 (pt)
CO (1) CO6531463A2 (pt)
CR (1) CR20120173A (pt)
EC (1) ECSP12011865A (pt)
ES (1) ES2609767T3 (pt)
HK (1) HK1175125A1 (pt)
IL (1) IL219105A0 (pt)
MA (1) MA33974B1 (pt)
MX (1) MX345155B (pt)
NZ (1) NZ599939A (pt)
PE (1) PE20121816A1 (pt)
RU (1) RU2563193C2 (pt)
TW (1) TWI428336B (pt)
WO (1) WO2011054620A1 (pt)
ZA (1) ZA201202618B (pt)

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CA2729914A1 (en) 2008-07-11 2010-01-14 Novartis Ag Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
EA024252B1 (ru) 2009-01-08 2016-08-31 Кьюрис, Инк. Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой
CN102791715B (zh) 2009-12-31 2016-04-27 卡洛斯三世国家癌症研究中心基金会 用作激酶抑制剂的三环化合物
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
AU2012236367B2 (en) 2011-04-01 2014-10-09 Curis, Inc. Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
TW201840336A (zh) * 2011-08-01 2018-11-16 美商建南德克公司 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
CN103764144B (zh) * 2011-08-31 2016-07-20 诺华股份有限公司 Pi3k抑制剂与mek抑制剂的协同组合
CA2849331A1 (en) 2011-10-13 2013-04-18 Genentech, Inc. Treatment of pharmacological-induced hypochlorhydria
MX2014004991A (es) * 2011-10-28 2014-05-22 Genentech Inc Combinaciones terapeuticas y metodos para tratar el melanoma.
WO2013082511A1 (en) 2011-12-02 2013-06-06 Genentech, Inc. Methods for overcoming tumor resistance to vegf antagonists
EA201491836A1 (ru) * 2012-04-06 2015-02-27 Санофи Способы лечения рака с использованием ингибитора pi3k и ингибитора mek
EP2851078B1 (en) * 2012-04-19 2017-06-07 Kyushu University, National University Corporation Pharmaceutical composition
NZ702244A (en) 2012-06-08 2017-06-30 Hoffmann La Roche Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
CA2879665A1 (en) 2012-08-02 2014-02-06 Genentech, Inc. Anti-etbr antibodies and immunoconjugates
CN104797270A (zh) 2012-08-02 2015-07-22 基因泰克公司 抗etbr抗体和免疫偶联物
BR112015003418A2 (pt) * 2012-08-17 2017-07-04 Hoffmann La Roche produto farmacêutico, conjunto, métodos para estender a duração da resposta ao tratamento, de retardar ou prevenir o desenvolvimento de resistência ao tratamento, para a seleção de uma terapia e para otimizar a eficácia terapêutica.
CN105246508A (zh) * 2013-03-14 2016-01-13 基因泰克公司 Mek抑制剂化合物与her3/egfr抑制剂化合物的组合及使用方法
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
EP3102232B1 (en) 2014-02-07 2020-02-05 Verastem, Inc. Methods and compositions for treating abnormal cell growth
CN106573060A (zh) 2014-07-15 2017-04-19 豪夫迈·罗氏有限公司 使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物
JP6692798B2 (ja) * 2014-09-11 2020-05-13 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア ｍＴＯＲＣ１阻害剤
KR20210087438A (ko) 2018-09-11 2021-07-12 쿠리스 인코퍼레이션 아연 결합 모이어티를 가진 포스포이노시티드 3-키나제 저해제를 이용한 병용 요법
CN110420330B (zh) * 2019-07-19 2020-05-29 南京医科大学 一种pi3k与mth1靶向药组合物的制药用途
JP2022547358A (ja) 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル 治療組成物、組み合わせ、及び使用方法
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

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US7538120B2 (en) * 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
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US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
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EA025871B9 (ru) * 2005-10-07 2017-08-31 Экселиксис, Инк. Ингибиторы mek и способы их применения
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US8247397B2 (en) * 2007-09-12 2012-08-21 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
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Also Published As

Publication number Publication date
MX2012004286A (es) 2012-05-22
RU2563193C2 (ru) 2015-09-20
MA33974B1 (fr) 2013-02-01
JP2015038110A (ja) 2015-02-26
RU2012118974A (ru) 2013-11-20
TWI428336B (zh) 2014-03-01
AR078588A1 (es) 2011-11-16
JP2013507415A (ja) 2013-03-04
ES2609767T3 (es) 2017-04-24
NZ599939A (en) 2014-02-28
WO2011054620A1 (en) 2011-05-12
CO6531463A2 (es) 2012-09-28
TW201118082A (en) 2011-06-01
IL219105A0 (en) 2012-06-28
PE20121816A1 (es) 2013-01-02
US20110086837A1 (en) 2011-04-14
CN102740851A (zh) 2012-10-17
CR20120173A (es) 2012-07-04
MX345155B (es) 2017-01-18
AU2010314287A1 (en) 2012-05-03
CA2776944A1 (en) 2011-05-12
ZA201202618B (en) 2014-10-29
ECSP12011865A (es) 2012-06-29
JP5745678B2 (ja) 2015-07-08
EP2488178A1 (en) 2012-08-22
EP2488178B1 (en) 2016-11-16
CL2012000913A1 (es) 2012-09-14
HK1175125A1 (en) 2013-06-28
CN102740851B (zh) 2013-12-18
KR20120064132A (ko) 2012-06-18
KR101489045B1 (ko) 2015-02-02
AU2010314287A2 (en) 2012-07-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.