MXPA04006255A - Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. - Google Patents

Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.

Info

Publication number
MXPA04006255A
MXPA04006255A MXPA04006255A MXPA04006255A MXPA04006255A MX PA04006255 A MXPA04006255 A MX PA04006255A MX PA04006255 A MXPA04006255 A MX PA04006255A MX PA04006255 A MXPA04006255 A MX PA04006255A MX PA04006255 A MXPA04006255 A MX PA04006255A
Authority
MX
Mexico
Prior art keywords
asbt
inhibitors
bile acid
keto
acid transport
Prior art date
Application number
MXPA04006255A
Other languages
English (en)
Inventor
Samuel J Tremont
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MXPA04006255A publication Critical patent/MXPA04006255A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/04—Seven-membered rings not condensed with other rings

Abstract

Se describen inhibidores del transporte del acido biliar codependiente del sodio apical (ASBT) de la tiepina, junto con los metodos para hacer los mismos, metodos para utilizar los mismos para tratar condiciones hiperlipidemicas, asi como composiciones farmaceuticas que contienen los mismos compuestos.
MXPA04006255A 2002-01-17 2003-01-15 Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. MXPA04006255A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34860502P 2002-01-17 2002-01-17
PCT/US2003/000025 WO2003061604A2 (en) 2002-01-17 2003-01-15 Novel alkyl/aryl hydroxy or keto thiepines.

Publications (1)

Publication Number Publication Date
MXPA04006255A true MXPA04006255A (es) 2004-09-27

Family

ID=27613232

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04006255A MXPA04006255A (es) 2002-01-17 2003-01-15 Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.

Country Status (8)

Country Link
US (1) US6852753B2 (es)
EP (1) EP1465885A4 (es)
JP (1) JP2005521653A (es)
AU (1) AU2003207431A1 (es)
BR (1) BR0306643A (es)
CA (1) CA2471639A1 (es)
MX (1) MXPA04006255A (es)
WO (1) WO2003061604A2 (es)

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US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
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US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP2367554A4 (en) * 2008-11-26 2020-03-25 Satiogen Pharmaceuticals, Inc. BILIARY ACID RECYCLING INHIBITORS FOR THE TREATMENT OF OBESITY AND DIABETES
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ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
BR112014010223B8 (pt) 2011-10-28 2021-02-23 Lumena Pharmaceuticals Llc uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
CN104023718B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂
KR20230152818A (ko) 2013-03-15 2023-11-03 샤이어 휴먼 지네틱 테라피즈 인크. 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
RU2015139732A (ru) 2013-03-15 2017-04-24 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециркуляции желчных кислот для лечения пищевода барретта и гастроэзофагеальной рефлюксной болезни
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Also Published As

Publication number Publication date
WO2003061604A2 (en) 2003-07-31
CA2471639A1 (en) 2003-07-31
BR0306643A (pt) 2004-10-19
AU2003207431A1 (en) 2003-09-02
WO2003061604A3 (en) 2004-01-08
US20030195218A1 (en) 2003-10-16
EP1465885A4 (en) 2005-04-27
JP2005521653A (ja) 2005-07-21
EP1465885A2 (en) 2004-10-13
US6852753B2 (en) 2005-02-08

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