UY39706A - Derivados de (1hindol- 3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil) fenil)amino)etanona como inhibidores de la replicación del virus del dengue - Google Patents

Derivados de (1hindol- 3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil) fenil)amino)etanona como inhibidores de la replicación del virus del dengue

Info

Publication number
UY39706A
UY39706A UY0001039706A UY39706A UY39706A UY 39706 A UY39706 A UY 39706A UY 0001039706 A UY0001039706 A UY 0001039706A UY 39706 A UY39706 A UY 39706A UY 39706 A UY39706 A UY 39706A
Authority
UY
Uruguay
Prior art keywords
methoxy
phenyl
methylsulfonyl
chloro
amino
Prior art date
Application number
UY0001039706A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Bart Rudolf Romaine Kesteleyn
Tim Hugo Maria Jonckers
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of UY39706A publication Critical patent/UY39706A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se divulgan derivados de (1H-indol-3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil)fenil)amino) etanona, métodos para prevenir o tratar infecciones por el virus del dengue usando dichos compuestos como medicamento. La invención se refiere además a composiciones farmacéuticas o preparaciones a partir de combinación de compuestos para uso como medicamento. La invención también se refiere a los procesos de preparación de los compuestos.
UY0001039706A 2015-05-08 2016-05-06 Derivados de (1hindol- 3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil) fenil)amino)etanona como inhibidores de la replicación del virus del dengue UY39706A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166900 2015-05-08
EP16163342 2016-03-31
UY0001036674A UY36674A (es) 2015-05-08 2016-05-06 Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue

Publications (1)

Publication Number Publication Date
UY39706A true UY39706A (es) 2022-05-31

Family

ID=56026812

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001039706A UY39706A (es) 2015-05-08 2016-05-06 Derivados de (1hindol- 3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil) fenil)amino)etanona como inhibidores de la replicación del virus del dengue
UY0001036674A UY36674A (es) 2015-05-08 2016-05-06 Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY0001036674A UY36674A (es) 2015-05-08 2016-05-06 Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue

Country Status (38)

Country Link
US (3) US10696632B2 (es)
EP (2) EP3294738B1 (es)
JP (4) JP6752821B2 (es)
KR (2) KR102610491B1 (es)
CN (3) CN107873022B (es)
AU (2) AU2016259677B2 (es)
BR (1) BR112017023904A2 (es)
CA (1) CA2981845C (es)
CL (1) CL2017002817A1 (es)
CO (1) CO2017012381A2 (es)
CR (2) CR20170490A (es)
CY (1) CY1124548T1 (es)
DK (1) DK3294738T3 (es)
EA (1) EA034978B1 (es)
EC (2) ECSP17073878A (es)
ES (2) ES2877404T3 (es)
GT (1) GT201700234A (es)
HK (2) HK1252446A1 (es)
HR (1) HRP20210675T1 (es)
HU (1) HUE054724T2 (es)
IL (2) IL255430B (es)
JO (2) JOP20160086B1 (es)
LT (1) LT3294738T (es)
MD (1) MD3294738T2 (es)
MX (2) MX2017014293A (es)
NI (1) NI201700137A (es)
PE (2) PE20221579A1 (es)
PH (1) PH12017502000B1 (es)
PL (1) PL3294738T3 (es)
RS (1) RS62029B1 (es)
SG (1) SG10201900315SA (es)
SI (1) SI3294738T1 (es)
SV (1) SV2017005557A (es)
TW (2) TWI744963B (es)
UA (1) UA121332C2 (es)
UY (2) UY39706A (es)
WO (1) WO2016180696A1 (es)
ZA (1) ZA202002435B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AU2017242893A1 (en) 2016-03-31 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102359766B1 (ko) * 2016-04-01 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
UA125407C2 (uk) 2017-05-22 2022-03-02 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге
CN110753682B (zh) * 2017-05-22 2023-06-30 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物
US20220409583A1 (en) 2019-11-15 2022-12-29 Janssen Pharmaceuticals, Inc. Treatment and Prevention of Dengue Disease
WO2022094816A1 (en) 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Solid formulation
WO2022094817A1 (en) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Pharmaceutical formulation
CN113024440B (zh) * 2021-03-17 2023-05-16 凯莱英医药集团（天津）股份有限公司 连续化合成取代吲哚-2-羧酸的方法
AU2022304189A1 (en) 2021-06-29 2024-02-15 Janssen Pharmaceuticals, Inc. Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives
WO2023218285A1 (en) 2022-05-12 2023-11-16 Janssen Pharmaceuticals, Inc. Treatment or prevention of dengue viral infection
CN115521307B (zh) * 2022-09-30 2023-09-22 甘肃皓天医药科技有限责任公司 一种5-卤代-7-氮杂吲哚的制备方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE296286T1 (de) 1997-10-27 2005-06-15 Lilly Co Eli Morpholino-n-ethyl ester prodrogen von indol spla 2 hemmer
GB0110832D0 (en) 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
CA2468202A1 (en) 2001-12-12 2003-06-19 Conforma Therapeutics Corporation Assays and implements for determining and modulating hsp90 binding activity
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US20060211698A1 (en) 2005-01-14 2006-09-21 Genelabs, Inc. Bicyclic heteroaryl derivatives for treating viruses
MX2007009561A (es) 2005-02-09 2008-01-14 Migenix Inc Composiciones y metodos para tratar o evitar infecciones de flaviviridae.
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
BRPI0909985A2 (pt) 2008-06-03 2015-08-25 Siga Technologies Inc Composição farmacêutica e método para o tratamento ou profilaxia de uma infecção viral ou doença associada à mesma
MX2011001872A (es) * 2008-08-18 2011-05-23 Univ Yale Moduladores de mif.
ES2612731T3 (es) 2008-08-19 2017-05-18 Janssen Pharmaceutica Nv Antagonistas de receptores al frío de mentol
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
EP2393359A4 (en) 2009-02-09 2012-10-03 Enanta Pharm Inc COMPOUND DIBENZIMIDAZOLE DERIVATIVES
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
JP5777223B2 (ja) 2010-01-15 2015-09-09 ギリアード サイエンシーズ， インコーポレイテッド フラビウイルス科ウイルスのインヒビター
JP2013523657A (ja) 2010-03-26 2013-06-17 グラクソ グループ リミテッド キナーゼ阻害剤としてのインダゾリル‐ピリミジン
JP5716205B2 (ja) 2011-03-29 2015-05-13 学校法人日本大学 グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
US9567299B2 (en) 2013-10-23 2017-02-14 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2015116886A1 (en) 2014-01-31 2015-08-06 Bristol-Myers Squibb Company Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
ES2709994T3 (es) 2014-06-04 2019-04-22 Amgen Inc Métodos de recolección en cultivos de células de mamífero
CN106459919B (zh) 2014-06-04 2021-03-23 弗莱德哈钦森癌症研究中心 使用notch 1和/或notch 2激动剂扩增和植入干细胞
NO2721243T3 (es) 2014-10-01 2018-10-20
WO2016050831A1 (en) * 2014-10-01 2016-04-07 Janssen Pharmaceuticals, Inc. Mono- or di-substituted indoles as dengue viral replication inhibitors
EA032546B1 (ru) * 2014-10-01 2019-06-28 Янссен Фармасьютикалз, Инк. Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге
ES2896198T3 (es) 2014-10-10 2022-02-24 Univ Rutgers Cebadores y sondas de reacción en cadena de polimerasa para Mycobacterium tuberculosis
JOP20150335B1 (ar) * 2015-01-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AU2016296923B2 (en) 2015-07-22 2019-02-21 Board Of Regents, The University Of Texas System Metabolically robust analogs of CYP-eicosanoids for the treatment of cardiac disease
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
ES2907686T3 (es) 2015-11-03 2022-04-26 Zoetis Services Llc Compuestos poliméricos sol-gel y sus usos
AR108012A1 (es) 2016-03-31 2018-07-04 Takeda Pharmaceuticals Co Derivados de azaespiro[3,4]octan-6-ona como inhibidores de magl
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
AU2017242893A1 (en) 2016-03-31 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
NZ746554A (en) 2016-04-01 2023-03-31 Signal Pharm Llc Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
KR102359766B1 (ko) 2016-04-01 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체
KR20200068750A (ko) 2016-04-01 2020-06-15 카이트 파마 인코포레이티드 키메라 수용체 및 그의 사용 방법
MX2018012016A (es) 2016-04-01 2019-01-24 Basf Se Compuestos biciclicos.
WO2017173410A1 (en) 2016-04-01 2017-10-05 Amgen Inc. Chimeric receptors to flt3 and methods of use thereof
AU2017240667C1 (en) 2016-04-01 2022-11-24 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
UA125407C2 (uk) 2017-05-22 2022-03-02 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге
CN110753682B (zh) 2017-05-22 2023-06-30 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物

Also Published As

Publication number Publication date
US20180346419A1 (en) 2018-12-06
ES2877404T3 (es) 2021-11-16
TW201704208A (zh) 2017-02-01
IL255430A0 (en) 2017-12-31
AU2020273314A1 (en) 2020-12-17
SG10201900315SA (en) 2019-02-27
JP2018515495A (ja) 2018-06-14
TWI744963B (zh) 2021-11-01
WO2016180696A1 (en) 2016-11-17
HUE054724T2 (hu) 2021-09-28
UY36674A (es) 2016-11-30
US10696632B2 (en) 2020-06-30
JP2020125316A (ja) 2020-08-20
JOP20160086B1 (ar) 2021-08-17
NI201700137A (es) 2019-05-07
KR20180002644A (ko) 2018-01-08
IL272814B (en) 2021-02-28
JP7132399B2 (ja) 2022-09-06
US20210171462A1 (en) 2021-06-10
SV2017005557A (es) 2018-06-26
KR20210048578A (ko) 2021-05-03
KR102610493B1 (ko) 2023-12-05
MD3294738T2 (ro) 2021-08-31
AU2020273314B2 (en) 2021-10-21
US11827602B2 (en) 2023-11-28
US10919854B2 (en) 2021-02-16
EA034978B1 (ru) 2020-04-14
HRP20210675T1 (hr) 2021-06-25
ECSP17073878A (es) 2018-02-28
JP6898493B2 (ja) 2021-07-07
PE20180232A1 (es) 2018-01-31
TWI725969B (zh) 2021-05-01
EP3294738B1 (en) 2021-04-07
CN111303000A (zh) 2020-06-19
ES2941674T3 (es) 2023-05-24
EP3896072A1 (en) 2021-10-20
AU2016259677A1 (en) 2017-10-26
EP3294738A1 (en) 2018-03-21
MX2017014293A (es) 2018-08-09
CO2017012381A2 (es) 2018-03-28
ZA202002435B (en) 2023-03-29
JP2022166289A (ja) 2022-11-01
MX2020011156A (es) 2022-04-21
CA2981845C (en) 2022-03-08
IL255430B (en) 2020-03-31
EA201792429A1 (ru) 2018-02-28
CN111303000B (zh) 2023-11-28
NZ736934A (en) 2023-11-24
JP2021138752A (ja) 2021-09-16
JP6752821B2 (ja) 2020-09-09
TW202041499A (zh) 2020-11-16
CA2981845A1 (en) 2016-11-17
UA121332C2 (uk) 2020-05-12
PL3294738T3 (pl) 2021-12-13
PH12017502000A1 (en) 2018-03-26
CN107873022B (zh) 2021-03-12
CL2017002817A1 (es) 2018-05-11
CY1124548T1 (el) 2022-07-22
KR102610491B1 (ko) 2023-12-06
LT3294738T (lt) 2021-08-25
DK3294738T3 (da) 2021-06-28
CR20200152A (es) 2020-09-08
EP3896072B1 (en) 2022-11-16
PE20221579A1 (es) 2022-10-06
JOP20210109A1 (ar) 2023-01-30
HK1252496A1 (zh) 2019-05-31
AU2016259677B2 (en) 2020-10-01
PH12017502000B1 (en) 2018-03-26
GT201700234A (es) 2018-11-26
SI3294738T1 (sl) 2021-08-31
CN107873022A (zh) 2018-04-03
ECSP22023220A (es) 2022-05-31
HK1252446A1 (zh) 2019-05-24
CR20170490A (es) 2018-03-08
US20200270209A1 (en) 2020-08-27
BR112017023904A2 (pt) 2018-07-17
CN113045476A (zh) 2021-06-29
IL272814A (en) 2020-04-30
RS62029B1 (sr) 2021-07-30
JP7451626B2 (ja) 2024-03-18

Similar Documents

Publication Publication Date Title
UY39706A (es) Derivados de (1hindol- 3-il)-2-(4-cloro-2-metoxi-fenil)-2-((3-metoxi-5-(metilsulfonil) fenil)amino)etanona como inhibidores de la replicación del virus del dengue
UY37182A (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue
CO2019000386A2 (es) Compuestos heterocíclicos como inmunomoduladores
UY37645A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
UY37741A (es) Derivados de indolina sustituidos como inhibidores de la replicación del virus del dengue
CO2018008421A2 (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CL2018002784A1 (es) Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue.
UY37646A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CL2018003135A1 (es) Derivados aromáticos de sulfonamida.
CL2016002148A1 (es) Derivados de fenilen-1,5-diamina 2,4-disustituidos y aplicaciones de los mismos, y composiciones farmacéuticas y composiciones farmacéuticamente aceptables preparadas a partir de los mismos.
UY37742A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
EA201791256A1 (ru) Производные хиназолина, применяемые для лечения вич
BR112017003054A2 (pt) compostos de aminopirimidinila como inibidores de jak
CL2018002729A1 (es) Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue.
UY36340A (es) Derivados de indoles mono- o disustituidos como inhibidores de la replicación del virus del dengue
CO2020004301A2 (es) Derivados de 1-benzil-2-imino-4-fenil-5-oxoimidazolidina como inhibidores de la proteasa del vih
GT201600269A (es) Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble
EA201791304A1 (ru) Производные изохинолина для лечения вич
UY36339A (es) Indoles mono o disustituidos como inhibidores de la replicación del virus del dengue
UY36518A (es) Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue
BR112017006085A2 (pt) compostos 1-alquil-6-oxo-1,6-di-hidropiridin-3-ila e uso como moduladores sgrm
BR112017000246A2 (pt) composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto ou de um sal
MX2020003732A (es) Derivado de anillo fusionado como inhibidor del receptor a2a.
CR20160527A (es) Derivados de carboxamida
UY36123A (es) Derivados de carboxamida

Legal Events

Date Code Title Description
RDES Application refused

Effective date: 20240408