UY37182A - Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue - Google Patents
Derivados de indolina sustituidos como inhibidores de la replicación viral del dengueInfo
- Publication number
- UY37182A UY37182A UY0001037182A UY37182A UY37182A UY 37182 A UY37182 A UY 37182A UY 0001037182 A UY0001037182 A UY 0001037182A UY 37182 A UY37182 A UY 37182A UY 37182 A UY37182 A UY 37182A
- Authority
- UY
- Uruguay
- Prior art keywords
- dengue
- indolina
- inhibitors
- viral replication
- medicament
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se divulgan derivados de indolina sustituidos, métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos como medicamento, más preferentemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue. Se divulgan también composiciones farmacéuticas o preparados combinados de los compuestos para su uso como un medicamento, para la prevención o el tratamiento de infecciones virales por dengue. Se presentan procesos para la preparación de los compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163488 | 2016-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY37182A true UY37182A (es) | 2017-09-29 |
Family
ID=55650311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001037182A UY37182A (es) | 2016-04-01 | 2017-03-31 | Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10689340B2 (es) |
| EP (1) | EP3436437B1 (es) |
| JP (1) | JP6970115B2 (es) |
| KR (1) | KR102359776B1 (es) |
| CN (1) | CN108884037B (es) |
| AR (1) | AR108046A1 (es) |
| AU (1) | AU2017242894B2 (es) |
| BR (1) | BR112018068640A2 (es) |
| CA (1) | CA3013406C (es) |
| CL (1) | CL2018002758A1 (es) |
| CO (1) | CO2018009563A2 (es) |
| CR (1) | CR20180493A (es) |
| DK (1) | DK3436437T3 (es) |
| EA (1) | EA037988B1 (es) |
| EC (1) | ECSP18073293A (es) |
| ES (1) | ES2884067T3 (es) |
| HR (1) | HRP20211278T1 (es) |
| HU (1) | HUE055577T2 (es) |
| IL (1) | IL261948B (es) |
| JO (1) | JOP20170069B1 (es) |
| LT (1) | LT3436437T (es) |
| MX (1) | MX2018011785A (es) |
| MY (1) | MY195194A (es) |
| PE (1) | PE20181778A1 (es) |
| PH (1) | PH12018502077A1 (es) |
| SG (1) | SG11201808409XA (es) |
| SI (1) | SI3436437T1 (es) |
| TW (1) | TWI723148B (es) |
| UA (1) | UA125296C2 (es) |
| UY (1) | UY37182A (es) |
| WO (1) | WO2017167951A1 (es) |
| ZA (1) | ZA201806482B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MA44498A (fr) * | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| WO2017167952A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) * | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3630724B1 (en) * | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112019024195A2 (pt) * | 2017-05-22 | 2020-06-23 | Janssen Pharmaceuticals, Inc. | Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue |
| TW202132269A (zh) | 2019-11-15 | 2021-09-01 | 美商健生醫藥公司 | 登革熱疾病及治療和預防 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1200899A (en) | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| WO2006076529A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| PE20121522A1 (es) | 2010-01-15 | 2012-11-26 | Gilead Sciences Inc | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae |
| WO2011120025A1 (en) | 2010-03-26 | 2011-09-29 | Glaxo Group Limited | Indazolyl-pyrimidines as kinase inhibitors |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) * | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| LT3099687T (lt) | 2014-01-31 | 2018-09-10 | Bristol-Myers Squibb Company | Makrociklai su heterociklinėmis p2' grupėmis kaip faktoriaus xia inhibitoriai |
| AU2015326920A1 (en) | 2014-10-01 | 2017-03-02 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
| TWI681951B (zh) | 2014-10-01 | 2020-01-11 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之單-或二-取代的吲哚衍生物 |
| JOP20150335B1 (ar) * | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2016350868B2 (en) | 2015-11-03 | 2022-03-31 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| WO2017167952A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
| JP2019513370A (ja) | 2016-04-01 | 2019-05-30 | カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａ | キメラ受容体及びその使用方法 |
| MX2018011992A (es) | 2016-04-01 | 2019-01-24 | Signal Pharm Llc | Compuestos de aminopurina sustituida, composiciones de estos y metodos de tratamiento con estos. |
| SG10201911963VA (en) | 2016-04-01 | 2020-02-27 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
| IL303785A (en) | 2016-04-01 | 2023-08-01 | Kite Pharma Inc | Chimeric antigen and T cell receptors and methods of use |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| BR112019024195A2 (pt) | 2017-05-22 | 2020-06-23 | Janssen Pharmaceuticals, Inc. | Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue |
| EP3630724B1 (en) | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
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2017
- 2017-03-22 JO JOP/2017/0069A patent/JOP20170069B1/ar active
- 2017-03-30 AR ARP170100795A patent/AR108046A1/es unknown
- 2017-03-30 TW TW106110686A patent/TWI723148B/zh active
- 2017-03-31 CO CONC2018/0009563A patent/CO2018009563A2/es unknown
- 2017-03-31 MX MX2018011785A patent/MX2018011785A/es unknown
- 2017-03-31 ES ES17714751T patent/ES2884067T3/es active Active
- 2017-03-31 CA CA3013406A patent/CA3013406C/en active Active
- 2017-03-31 UY UY0001037182A patent/UY37182A/es unknown
- 2017-03-31 SG SG11201808409XA patent/SG11201808409XA/en unknown
- 2017-03-31 BR BR112018068640A patent/BR112018068640A2/pt active Search and Examination
- 2017-03-31 JP JP2018550545A patent/JP6970115B2/ja active Active
- 2017-03-31 HU HUE17714751A patent/HUE055577T2/hu unknown
- 2017-03-31 US US16/088,090 patent/US10689340B2/en active Active
- 2017-03-31 CR CR20180493A patent/CR20180493A/es unknown
- 2017-03-31 HR HRP20211278TT patent/HRP20211278T1/hr unknown
- 2017-03-31 AU AU2017242894A patent/AU2017242894B2/en active Active
- 2017-03-31 UA UAA201810728A patent/UA125296C2/uk unknown
- 2017-03-31 WO PCT/EP2017/057661 patent/WO2017167951A1/en active Application Filing
- 2017-03-31 EP EP17714751.9A patent/EP3436437B1/en active Active
- 2017-03-31 KR KR1020187028180A patent/KR102359776B1/ko active IP Right Grant
- 2017-03-31 EA EA201892219A patent/EA037988B1/ru unknown
- 2017-03-31 DK DK17714751.9T patent/DK3436437T3/da active
- 2017-03-31 CN CN201780021323.0A patent/CN108884037B/zh active Active
- 2017-03-31 MY MYPI2018001596A patent/MY195194A/en unknown
- 2017-03-31 SI SI201730871T patent/SI3436437T1/sl unknown
- 2017-03-31 PE PE2018001870A patent/PE20181778A1/es unknown
- 2017-03-31 LT LTEP17714751.9T patent/LT3436437T/lt unknown
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2018
- 2018-09-26 IL IL261948A patent/IL261948B/en unknown
- 2018-09-27 PH PH12018502077A patent/PH12018502077A1/en unknown
- 2018-09-27 CL CL2018002758A patent/CL2018002758A1/es unknown
- 2018-09-28 EC ECSENADI201873293A patent/ECSP18073293A/es unknown
- 2018-09-28 ZA ZA2018/06482A patent/ZA201806482B/en unknown
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2020
- 2020-06-05 US US16/893,685 patent/US11180450B2/en active Active
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