AR109296A1 - Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) - Google Patents
Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat)Info
- Publication number
- AR109296A1 AR109296A1 ARP170102213A ARP170102213A AR109296A1 AR 109296 A1 AR109296 A1 AR 109296A1 AR P170102213 A ARP170102213 A AR P170102213A AR P170102213 A ARP170102213 A AR P170102213A AR 109296 A1 AR109296 A1 AR 109296A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- heterocyclyl
- cycloalkyl
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1), en donde X es CH o N; R¹ se selecciona del grupo que consiste en CH₃, -CH₂OH y Cl; R² se selecciona, independientemente entre sí, del grupo que consiste en H, F, Cl, Br, I, CN, C₁₋₆-alquilo, C₃₋₇-cicloalquilo, OH, -O-(C₁₋₆-alquilo), -O-(C₃₋₇-cicloalquilo), -O-(C₁₋₃-alquil)-(C₃₋₇-cicloalquilo), -O-heterociclilo, -O-(C₁₋₃-alquil)-heterociclilo, -O-arilo, -O-heteroarilo, -S-(C₁₋₃-alquilo), -SO-(C₁₋₃-alquilo), -SO₂-(C₁₋₃-alquilo), -NH₂, -NH-(C₁₋₆-alquilo), -NH-(C₃₋₆-cicloalquilo), -NH-(C₁₋₃-alquil)-heterociclilo, -NH-(C₁₋₆-alquil)-C(=O)-NH₂, -C(=O)-NH₂, -C(=O)-NH-(C₁₋₃-alquilo), -C(=O)-N(C₁₋₃-alquilo)₂, -C(=O)OH, -C(=O)-O-(C₁₋₄-alquilo), -C(=O)-(C₁₋₄-alquilo), -C₁₋₃-alquil-C(=O)-O-(C₁₋₄-alquilo), heterociclilo, heteroarilo y 5,6-dihidro-4H-pirrolo[1,2-b]pirazol-3-ilo, en donde cada grupo alquilo o cicloalquilo, de manera opcional, se sustituye independientemente con uno o más sustituyentes seleccionados del grupo que consiste en F, CN y OH, y en donde cada grupo heterociclilo se selecciona de un grupo cicloalquilo mono- o espirocíclico de 4 - 7 miembros, en donde 1, 2 ó 3 grupos CH₂ se reemplazan, independientemente entre sí, por O, S, NH o C=O, y en donde cada grupo heterociclilo se sustituye opcionalmente con 1 ó 2 sustituyentes seleccionados, independientemente entre sí, de F, OH y C₁₋₃-alquilo, en donde cada grupo arilo se selecciona de un grupo que consiste en fenilo y naftilo, y en donde cada grupo heteroarilo se selecciona de un ciclo aromático de 5 miembros que contiene 1 ó 2 heteroátomos seleccionados independientemente de N, O y S, o de un ciclo aromático de 6 miembros que contiene 1 ó 2 N, y en donde cada grupo arilo o heteroarilo se sustituye opcionalmente con 1 ó 2 sustituyentes seleccionados independientemente de un grupo que consiste en F, CN y C₁₋₃-alquilo, que se sustituye opcionalmente con uno o más F; o, si dos grupos R² están unidos a átomos de C adyacentes del grupo piridina o pirimidina, se pueden unir y juntos formar un puente -O-CH₂-O-, -O-CH₂-CH₂-O- o -O-CH₂-CH₂-CH₂-O-, en donde 1 ó 2 átomos de H se pueden reemplazar por F o C₁₋₃-alquilo; y n es 1, 2 ó 3; en donde cada uno de los grupos alquilo mencionados anteriormente se puede sustituir con uno o más F; o una sal de estos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183047 | 2016-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109296A1 true AR109296A1 (es) | 2018-11-14 |
Family
ID=56609762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102213A AR109296A1 (es) | 2016-08-05 | 2017-08-04 | Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9994591B2 (es) |
| EP (1) | EP3494120B1 (es) |
| JP (1) | JP6651054B2 (es) |
| KR (1) | KR102496075B1 (es) |
| CN (1) | CN109843891B (es) |
| AR (1) | AR109296A1 (es) |
| AU (1) | AU2017307033B2 (es) |
| CA (1) | CA3033058A1 (es) |
| CL (1) | CL2019000274A1 (es) |
| CO (1) | CO2019000601A2 (es) |
| CY (1) | CY1124381T1 (es) |
| DK (1) | DK3494120T3 (es) |
| EA (1) | EA037277B1 (es) |
| ES (1) | ES2874587T3 (es) |
| HR (1) | HRP20210908T1 (es) |
| HU (1) | HUE054928T2 (es) |
| IL (1) | IL264506B (es) |
| LT (1) | LT3494120T (es) |
| MA (1) | MA45843B1 (es) |
| MX (1) | MX2019001427A (es) |
| MY (1) | MY197064A (es) |
| PE (1) | PE20190414A1 (es) |
| PH (1) | PH12019500254A1 (es) |
| PL (1) | PL3494120T3 (es) |
| PT (1) | PT3494120T (es) |
| RS (1) | RS61937B1 (es) |
| SA (1) | SA519401039B1 (es) |
| SG (1) | SG11201811804QA (es) |
| SI (1) | SI3494120T1 (es) |
| TW (1) | TWI749042B (es) |
| UA (1) | UA124267C2 (es) |
| WO (1) | WO2018024653A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200116978A (ko) * | 2018-02-02 | 2020-10-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로서의 벤질-치환된, (피리딘-3-일)메틸-치환된 또는 (피리딘-4-일)메틸-치환된 옥사디아졸로피리딘 유도체 |
| AU2019215710A1 (en) | 2018-02-02 | 2020-07-23 | Boehringer Ingelheim International Gmbh | Triazolopyrimidine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| JP7225253B2 (ja) * | 2018-02-02 | 2023-02-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのピラゾール置換及びインダゾール置換オキサジアゾロピリジン誘導体 |
| KR20200118124A (ko) * | 2018-02-02 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로 사용하기 위한 헤테로사이클릴-치환된 옥사디아졸로피리딘 유도체 |
| WO2021233884A1 (en) | 2020-05-22 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
| JP2023526351A (ja) | 2020-05-22 | 2023-06-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの製造方法 |
| CN112014340A (zh) * | 2020-09-01 | 2020-12-01 | 广西玮美生物科技有限公司 | 非人灵长类动物胃饥饿素的检测方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241496B1 (es) | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| US20100197908A1 (en) | 2006-12-11 | 2010-08-05 | Boehringer Ingelheim International Gmbh | Pyridazine Derivatives with MCH Antagonistic Activity and Medicaments Comprising These Compounds |
| KR20150116465A (ko) | 2007-02-15 | 2015-10-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/ｇｌｐ-1 수용체 공동-항진물질 |
| JP5385266B2 (ja) | 2007-06-15 | 2014-01-08 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| EP2370462B1 (en) | 2008-12-15 | 2014-07-16 | Zealand Pharma A/S | Glucagon analogues |
| CA2747155A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| JP5635529B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| BRPI0823376A2 (pt) | 2008-12-15 | 2015-06-16 | Zealand Pharma As | Análagos de glucagon |
| EP2454282B1 (en) | 2009-07-13 | 2015-03-04 | Zealand Pharma A/S | Acylated glucagon analogues |
| AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
| CA2802897A1 (en) | 2010-06-24 | 2011-12-29 | Zealand Pharma A/S | Glucagon analogues |
| JP2015502380A (ja) | 2011-12-23 | 2015-01-22 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| WO2013125732A1 (en) * | 2012-02-24 | 2013-08-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| US20170275249A1 (en) * | 2014-09-17 | 2017-09-28 | The Regents Of The University Of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
| AR104673A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| AR104672A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| KR20200116978A (ko) | 2018-02-02 | 2020-10-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로서의 벤질-치환된, (피리딘-3-일)메틸-치환된 또는 (피리딘-4-일)메틸-치환된 옥사디아졸로피리딘 유도체 |
| AU2019215710A1 (en) | 2018-02-02 | 2020-07-23 | Boehringer Ingelheim International Gmbh | Triazolopyrimidine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| JP7225253B2 (ja) * | 2018-02-02 | 2023-02-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのピラゾール置換及びインダゾール置換オキサジアゾロピリジン誘導体 |
| KR20200118124A (ko) | 2018-02-02 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로 사용하기 위한 헤테로사이클릴-치환된 옥사디아졸로피리딘 유도체 |
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2017
- 2017-07-31 PL PL17743064T patent/PL3494120T3/pl unknown
- 2017-07-31 KR KR1020197006448A patent/KR102496075B1/ko active IP Right Grant
- 2017-07-31 EP EP17743064.2A patent/EP3494120B1/en active Active
- 2017-07-31 US US15/664,119 patent/US9994591B2/en active Active
- 2017-07-31 MX MX2019001427A patent/MX2019001427A/es unknown
- 2017-07-31 UA UAA201901840A patent/UA124267C2/uk unknown
- 2017-07-31 CA CA3033058A patent/CA3033058A1/en active Pending
- 2017-07-31 SI SI201730770T patent/SI3494120T1/sl unknown
- 2017-07-31 HU HUE17743064A patent/HUE054928T2/hu unknown
- 2017-07-31 EA EA201990418A patent/EA037277B1/ru not_active IP Right Cessation
- 2017-07-31 PT PT177430642T patent/PT3494120T/pt unknown
- 2017-07-31 LT LTEP17743064.2T patent/LT3494120T/lt unknown
- 2017-07-31 AU AU2017307033A patent/AU2017307033B2/en active Active
- 2017-07-31 PE PE2019000271A patent/PE20190414A1/es unknown
- 2017-07-31 ES ES17743064T patent/ES2874587T3/es active Active
- 2017-07-31 JP JP2019506164A patent/JP6651054B2/ja active Active
- 2017-07-31 CN CN201780047100.1A patent/CN109843891B/zh active Active
- 2017-07-31 MY MYPI2018002719A patent/MY197064A/en unknown
- 2017-07-31 RS RS20210702A patent/RS61937B1/sr unknown
- 2017-07-31 SG SG11201811804QA patent/SG11201811804QA/en unknown
- 2017-07-31 MA MA45843A patent/MA45843B1/fr unknown
- 2017-07-31 DK DK17743064.2T patent/DK3494120T3/da active
- 2017-07-31 WO PCT/EP2017/069274 patent/WO2018024653A1/en unknown
- 2017-08-04 TW TW106126319A patent/TWI749042B/zh active
- 2017-08-04 AR ARP170102213A patent/AR109296A1/es unknown
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2018
- 2018-05-09 US US15/974,882 patent/US10308667B2/en not_active Ceased
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2019
- 2019-01-22 CO CONC2019/0000601A patent/CO2019000601A2/es unknown
- 2019-01-28 IL IL264506A patent/IL264506B/en active IP Right Grant
- 2019-02-01 CL CL2019000274A patent/CL2019000274A1/es unknown
- 2019-02-05 SA SA519401039A patent/SA519401039B1/ar unknown
- 2019-02-06 PH PH12019500254A patent/PH12019500254A1/en unknown
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2020
- 2020-10-14 US US17/069,940 patent/USRE49446E1/en active Active
-
2021
- 2021-06-08 HR HRP20210908TT patent/HRP20210908T1/hr unknown
- 2021-06-14 CY CY20211100525T patent/CY1124381T1/el unknown
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