EA200970081A1 - Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения - Google Patents

Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения

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Publication number
EA200970081A1
EA200970081A1 EA200970081A EA200970081A EA200970081A1 EA 200970081 A1 EA200970081 A1 EA 200970081A1 EA 200970081 A EA200970081 A EA 200970081A EA 200970081 A EA200970081 A EA 200970081A EA 200970081 A1 EA200970081 A1 EA 200970081A1
Authority
EA
Eurasian Patent Office
Prior art keywords
activity
compounds
etionmide
respect
activated
Prior art date
Application number
EA200970081A
Other languages
English (en)
Inventor
Бенуа Депре
Николя Виллан
Бертран Дири
Патрик Тото
Венсан Виллере
Камилль Лохт
Ален Болар
Original Assignee
Энститю Пастер Де Лилль
Сантр Насьональ Де Ля Решерш Сьентифик
Юниверсите Де Лилль 2, Юниверсите Дю Друа Э Де Ля Санте
Энститю Насьональ Де Ля Санте Э Де Ля Решерш Медикаль (Энсэрм)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Энститю Пастер Де Лилль, Сантр Насьональ Де Ля Решерш Сьентифик, Юниверсите Де Лилль 2, Юниверсите Дю Друа Э Де Ля Санте, Энститю Насьональ Де Ля Санте Э Де Ля Решерш Медикаль (Энсэрм) filed Critical Энститю Пастер Де Лилль
Publication of EA200970081A1 publication Critical patent/EA200970081A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к применению соединений с потенциирующим действием на активность антибиотиков, активируемых через ферментативный путь EthA, для получения лекарственного средства для предупреждения и/или лечения микобактериальных инфекций, таких как туберкулез и лепра, к фармацевтическим композициям, содержащим их в сочетании с антибиотиком, активируемым через путь EthA, к соединениям, обладающим усиливающим эффектом на активность антибиотиков, активируемых через ферментативный путь EthA, к содержащим их фармацевтическим композициям и к их применению в качестве лекарственных средств, особенно лекарственных средств для предупреждения и/или лечения микобактериальных инфекций, таких как туберкулез и лепра.
EA200970081A 2006-07-04 2007-07-04 Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения EA200970081A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606088A FR2903405B1 (fr) 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
PCT/FR2007/001138 WO2008003861A1 (fr) 2006-07-04 2007-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications

Publications (1)

Publication Number Publication Date
EA200970081A1 true EA200970081A1 (ru) 2009-06-30

Family

ID=37775154

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970081A EA200970081A1 (ru) 2006-07-04 2007-07-04 Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения

Country Status (13)

Country Link
US (1) US8338599B2 (ru)
EP (1) EP2044064A1 (ru)
JP (1) JP2009541474A (ru)
KR (1) KR20090043506A (ru)
CN (1) CN101516876A (ru)
AP (1) AP2009004747A0 (ru)
AU (1) AU2007271013A1 (ru)
BR (1) BRPI0714225A2 (ru)
CA (1) CA2656502C (ru)
EA (1) EA200970081A1 (ru)
FR (1) FR2903405B1 (ru)
WO (1) WO2008003861A1 (ru)
ZA (1) ZA200810703B (ru)

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EP2234643B1 (en) 2007-12-21 2013-01-09 ETH Zurich Composition for treatment of tuberculosis
GB0813740D0 (en) * 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
CN102458393B (zh) 2009-06-25 2014-08-20 生物验证系统股份公司 治疗肺结核的组合物
GB0916608D0 (en) * 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2632460B1 (en) * 2010-09-20 2018-02-28 University of Virginia Patent Foundation Thiophene derivatives for use in the treatment of tuberculosis
EP2771338A2 (en) 2011-10-25 2014-09-03 Université de Droit et de la Santé de Lille 2 1, 2, 4 - oxadiazole derivatives as ethr inhibitors for use in the treatment tuberculosis
MY170524A (en) 2012-02-02 2019-08-09 Idorsia Pharmaceuticals Ltd 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
FR3000064A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
TR201807959T4 (tr) 2013-07-22 2018-06-21 Idorsia Pharmaceuticals Ltd 1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
NZ734542A (en) 2015-01-15 2023-02-24 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
JP7183270B2 (ja) * 2017-08-16 2022-12-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 新規化合物
CN111655687A (zh) * 2017-09-08 2020-09-11 Pi工业有限公司 新型杀真菌杂环化合物
CN108558858A (zh) * 2018-05-23 2018-09-21 成都师范学院 硝基呋喃类抗结核化合物
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP4168399A4 (en) * 2020-06-23 2024-06-05 Nanjing Immunophage Biotech Co., Ltd. COMPOUNDS AND THEIR USES AS MIF INHIBITORS

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US8207147B2 (en) * 2003-12-24 2012-06-26 Prosidion Limited Heterocyclic derivatives as GPCR receptor agonists
EP1604989A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft DPP-IV inhibitors
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Also Published As

Publication number Publication date
ZA200810703B (en) 2009-10-28
AU2007271013A1 (en) 2008-01-10
AP2009004747A0 (en) 2009-02-28
FR2903405B1 (fr) 2011-09-09
JP2009541474A (ja) 2009-11-26
US8338599B2 (en) 2012-12-25
CA2656502A1 (fr) 2008-01-10
CN101516876A (zh) 2009-08-26
KR20090043506A (ko) 2009-05-06
US20110136823A1 (en) 2011-06-09
BRPI0714225A2 (pt) 2013-01-29
FR2903405A1 (fr) 2008-01-11
WO2008003861A1 (fr) 2008-01-10
EP2044064A1 (fr) 2009-04-08
CA2656502C (fr) 2017-06-13

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