PE20081228A1 - Compuesto heteromonociclico - Google Patents
Compuesto heteromonociclicoInfo
- Publication number
- PE20081228A1 PE20081228A1 PE2007001629A PE2007001629A PE20081228A1 PE 20081228 A1 PE20081228 A1 PE 20081228A1 PE 2007001629 A PE2007001629 A PE 2007001629A PE 2007001629 A PE2007001629 A PE 2007001629A PE 20081228 A1 PE20081228 A1 PE 20081228A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- methyl
- diseases
- oxadiazol
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, EN DONDE R1 ES OXO, TIOXO, =N-R; R ES ALQUILO C1-C6 SUSTITUIDO O NO, OH, =N-CO-(ALQUILO C1-C6), ENTRE OTROS; X, X1 Y X2 SON CADA UNO C, N, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: 3-(4-ISOPROPOXIFENIL)-2-METIL-5-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-6-PROPILPIRIMIDIN-4(3H)-ONA; 6-BUTIL-2-METOXI-5-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3IL)BIFENIL-4-IL]METIL}-3-FENILPIRIMIDIN-4(3H)-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS TIENEN ACTIVIDAD INHIBITORIA DEL RECEPTOR DE ANGIOTENSINA II Y/O UNA ACTIVIDAD AGONISTA DEL RECEPTOR ACTIVADO POR EL PROLIFERADOR DE PEROXISOMAS, UTILES EN EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES CIRCULATORIAS, ENFERMEDADES METABOLICAS Y ENFERMEDADES DEL SITEMA NERVIOSO CENTRAL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006317839 | 2006-11-24 | ||
JP2007232106 | 2007-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081228A1 true PE20081228A1 (es) | 2008-10-29 |
Family
ID=39205144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001629A PE20081228A1 (es) | 2006-11-24 | 2007-11-23 | Compuesto heteromonociclico |
Country Status (21)
Country | Link |
---|---|
US (2) | US20100056526A1 (es) |
EP (2) | EP2074117A2 (es) |
JP (1) | JP2010510962A (es) |
KR (1) | KR20090085117A (es) |
AR (1) | AR063912A1 (es) |
AU (1) | AU2007322608A1 (es) |
BR (1) | BRPI0719060A2 (es) |
CA (1) | CA2670404A1 (es) |
CL (1) | CL2007003352A1 (es) |
CO (1) | CO6231035A2 (es) |
CR (1) | CR10847A (es) |
EA (1) | EA200970510A1 (es) |
EC (1) | ECSP099461A (es) |
IL (1) | IL198819A0 (es) |
MA (1) | MA30985B1 (es) |
MX (1) | MX2009005449A (es) |
NO (1) | NO20092415L (es) |
PE (1) | PE20081228A1 (es) |
TN (1) | TN2009000199A1 (es) |
TW (1) | TW200829581A (es) |
WO (1) | WO2008062905A2 (es) |
Families Citing this family (40)
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---|---|---|---|---|
US7103906B1 (en) | 2000-09-29 | 2006-09-05 | International Business Machines Corporation | User controlled multi-device media-on-demand system |
CN101715109A (zh) | 2000-10-11 | 2010-05-26 | 联合视频制品公司 | 提供数据存储到点播媒体传递系统中服务器上的系统和方法 |
US8086575B2 (en) | 2004-09-23 | 2011-12-27 | Rovi Solutions Corporation | Methods and apparatus for integrating disparate media formats in a networked media system |
US8607287B2 (en) | 2005-12-29 | 2013-12-10 | United Video Properties, Inc. | Interactive media guidance system having multiple devices |
US9681105B2 (en) | 2005-12-29 | 2017-06-13 | Rovi Guides, Inc. | Interactive media guidance system having multiple devices |
US20100056526A1 (en) * | 2006-11-24 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
US20090019492A1 (en) | 2007-07-11 | 2009-01-15 | United Video Properties, Inc. | Systems and methods for mirroring and transcoding media content |
PL2384327T3 (pl) * | 2009-01-30 | 2013-12-31 | Takeda Pharmaceuticals Co | Związki ze skondensowanym pierścieniem i ich zastosowanie |
TW201031659A (en) | 2009-02-23 | 2010-09-01 | Kowa Co | Novel compound having 3-(5-alkoxypyrimidin-2-yl) pyrimidin-4(3H)-on structure and medicine containg same |
JPWO2010119700A1 (ja) * | 2009-04-17 | 2012-10-22 | 興和株式会社 | 新規な3−ヘテロアリールピリミジン−4−(3h)−オン構造を有する化合物及びこれを含有する医薬 |
EP2436675A1 (en) | 2009-05-29 | 2012-04-04 | Kowa Company, Ltd. | Novel -phenoxybenzeneacetic acid derivative and pharmaceutical preparation comprising same |
WO2011024468A1 (ja) | 2009-08-27 | 2011-03-03 | 興和株式会社 | 新規なスルホンアミド誘導体及びこれを含有する医薬 |
US9014546B2 (en) | 2009-09-23 | 2015-04-21 | Rovi Guides, Inc. | Systems and methods for automatically detecting users within detection regions of media devices |
JP5583681B2 (ja) * | 2009-09-29 | 2014-09-03 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
WO2011077711A1 (ja) * | 2009-12-22 | 2011-06-30 | 興和株式会社 | 新規な2-ピリドン誘導体及びこれを含有する医薬 |
JPWO2011105099A1 (ja) * | 2010-02-25 | 2013-06-20 | 興和株式会社 | 新規な4−アルコキシピリミジン構造を有する化合物及びこれを含有する医薬 |
WO2011142381A1 (ja) * | 2010-05-11 | 2011-11-17 | Fujita Takashi | ベンゾ若しくはピリドイミダゾール誘導体 |
JPWO2012011592A1 (ja) * | 2010-07-23 | 2013-09-09 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
MX2013003749A (es) | 2010-10-07 | 2013-05-09 | Takeda Pharmaceutical | Derivados de 1,4-oxazepano. |
WO2012078674A1 (en) | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
EP3469907B1 (en) | 2010-12-06 | 2021-03-03 | Aclaris Therapeutics, Inc. | Substituted pyridinone-pyridinyl compounds |
US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
PL2687523T3 (pl) * | 2011-03-14 | 2016-06-30 | Kowa Co | Nowa pochodna fenylopirydyny i lek zawierający ją |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9056110B2 (en) | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
TWI613199B (zh) * | 2011-12-21 | 2018-02-01 | 小野藥品工業股份有限公司 | 化合物 |
JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
ES2869048T3 (es) | 2013-06-07 | 2021-10-22 | Aclaris Therapeutics Inc | Compuestos de piridinona-piridinilo sustituidos con metil/fluoro-piridinil-metoxi y compuestos de piridinona-piridinilo sustituidos con fluoro-pirimidinil-metoxi |
EP3010889B1 (de) | 2013-06-20 | 2018-10-03 | Bayer CropScience Aktiengesellschaft | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
WO2014202510A1 (de) | 2013-06-20 | 2014-12-24 | Bayer Cropscience Ag | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
US9674563B2 (en) | 2013-11-04 | 2017-06-06 | Rovi Guides, Inc. | Systems and methods for recommending content |
ES2663806T3 (es) | 2013-12-19 | 2018-04-17 | unshine Lake Pharma Co., Ltd. | Derivados heterocíclicos nitrogenados y su aplicación en el tratamiento de la fibrosis tisular |
BR112016022722B8 (pt) | 2014-04-01 | 2023-11-21 | Merck Sharp & Dohme | Composto, composição farmacêutica que o comprende e uso do mesmo |
HUE051080T2 (hu) | 2014-12-10 | 2021-03-01 | Ono Pharmaceutical Co | Dihidroindolizinon származék |
JP2019522671A (ja) | 2016-07-12 | 2019-08-15 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺虫剤としての二環式化合物 |
KR101984121B1 (ko) * | 2017-08-21 | 2019-05-30 | 보령제약 주식회사 | 피리미디논 유도체 화합물 및 이의 용도 |
EP4125891A1 (en) | 2020-03-27 | 2023-02-08 | Aclaris Therapeutics, Inc. | Process, compositions, and crystalline forms of substituted pyridinone-pyridinyl compounds |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
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AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
EP1227090A4 (en) | 1999-10-07 | 2002-11-20 | Tadeka Chemical Ind Ltd | AMIN DERIVATIVES |
PT1228067E (pt) | 1999-11-10 | 2004-11-30 | Takeda Chemical Industries Ltd | Compostos heterociclicos de cinco membros com actividade hipoglicemica e hipolipidemica |
PT1285651E (pt) | 2000-04-28 | 2010-10-21 | Takeda Pharmaceutical | Antagonistas da hormona concentradora da melanina |
US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
PL360398A1 (en) | 2000-07-13 | 2004-09-06 | Takeda Chemical Industries, Ltd. | Lipid-rich plaque inhibitors |
EP1437351A4 (en) | 2001-10-19 | 2005-06-01 | Takeda Pharmaceutical | AMINE DERIVATIVE |
EP1471064A4 (en) | 2002-01-11 | 2005-04-27 | Takeda Pharmaceutical | Cumarin derivatives, process for their preparation and their use |
CA2507026A1 (en) | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, their production and use |
US20100056526A1 (en) * | 2006-11-24 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
-
2007
- 2007-11-21 US US12/516,099 patent/US20100056526A1/en not_active Abandoned
- 2007-11-21 US US11/943,910 patent/US20080207654A1/en not_active Abandoned
- 2007-11-21 AU AU2007322608A patent/AU2007322608A1/en not_active Abandoned
- 2007-11-21 EP EP07832719A patent/EP2074117A2/en not_active Withdrawn
- 2007-11-21 EA EA200970510A patent/EA200970510A1/ru unknown
- 2007-11-21 BR BRPI0719060-3A2A patent/BRPI0719060A2/pt not_active IP Right Cessation
- 2007-11-21 JP JP2009521472A patent/JP2010510962A/ja not_active Abandoned
- 2007-11-21 WO PCT/JP2007/073004 patent/WO2008062905A2/en active Application Filing
- 2007-11-21 CA CA002670404A patent/CA2670404A1/en not_active Abandoned
- 2007-11-21 EP EP10173592A patent/EP2256115A1/en not_active Withdrawn
- 2007-11-21 KR KR1020097012959A patent/KR20090085117A/ko not_active Application Discontinuation
- 2007-11-21 MX MX2009005449A patent/MX2009005449A/es not_active Application Discontinuation
- 2007-11-23 TW TW096144409A patent/TW200829581A/zh unknown
- 2007-11-23 AR ARP070105204A patent/AR063912A1/es not_active Application Discontinuation
- 2007-11-23 CL CL200703352A patent/CL2007003352A1/es unknown
- 2007-11-23 PE PE2007001629A patent/PE20081228A1/es not_active Application Discontinuation
-
2009
- 2009-05-19 IL IL198819A patent/IL198819A0/en unknown
- 2009-05-20 TN TNP2009000199A patent/TN2009000199A1/fr unknown
- 2009-06-09 CR CR10847A patent/CR10847A/es unknown
- 2009-06-10 MA MA31977A patent/MA30985B1/fr unknown
- 2009-06-23 EC EC2009009461A patent/ECSP099461A/es unknown
- 2009-06-24 NO NO20092415A patent/NO20092415L/no not_active Application Discontinuation
- 2009-06-24 CO CO09065607A patent/CO6231035A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20092415L (no) | 2009-08-17 |
EP2256115A1 (en) | 2010-12-01 |
KR20090085117A (ko) | 2009-08-06 |
EP2074117A2 (en) | 2009-07-01 |
WO2008062905A2 (en) | 2008-05-29 |
CO6231035A2 (es) | 2010-12-20 |
EA200970510A1 (ru) | 2009-12-30 |
AR063912A1 (es) | 2009-02-25 |
WO2008062905A3 (en) | 2008-12-04 |
MA30985B1 (fr) | 2009-12-01 |
BRPI0719060A2 (pt) | 2014-02-04 |
US20100056526A1 (en) | 2010-03-04 |
ECSP099461A (es) | 2009-11-30 |
AU2007322608A2 (en) | 2009-07-16 |
IL198819A0 (en) | 2010-02-17 |
AU2007322608A1 (en) | 2008-05-29 |
CR10847A (es) | 2009-07-13 |
TW200829581A (en) | 2008-07-16 |
CL2007003352A1 (es) | 2008-07-04 |
US20080207654A1 (en) | 2008-08-28 |
CA2670404A1 (en) | 2008-05-29 |
MX2009005449A (es) | 2009-06-02 |
JP2010510962A (ja) | 2010-04-08 |
TN2009000199A1 (en) | 2010-10-18 |
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