PE20090741A1 - Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano - Google Patents

Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano

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Publication number
PE20090741A1
PE20090741A1 PE2008001670A PE2008001670A PE20090741A1 PE 20090741 A1 PE20090741 A1 PE 20090741A1 PE 2008001670 A PE2008001670 A PE 2008001670A PE 2008001670 A PE2008001670 A PE 2008001670A PE 20090741 A1 PE20090741 A1 PE 20090741A1
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PE
Peru
Prior art keywords
trifluor
alkyl
hydroxy
phenylpropane
butan
Prior art date
Application number
PE2008001670A
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English (en)
Inventor
Jacques Bailly
Cornelia Hertel
Daniel Hunziker
Christian Lerner
Ulrike Bost Sander
Jens-Uwe Peters
Philippe Pflieger
Tanja Schulz-Gasch
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090741A1 publication Critical patent/PE20090741A1/es

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 1,1,1-TRIFLUOR-2-HIDROXI-3-FENILPROPANO DE FORMULA (I) DONDE A ES C-R1b O N; R1a, R1b, R1c, R1d Y R1e SON CADA UNO H, ALQUILO(C1-C7), CICLOALQUIL(C3-C7)-ALQUILO(C1-C7), HALOGENO, HIDROXI, ENTRE OTROS; R2 ES ALQUILO(C1-C7), CICLOALQUIL(C3-C7)-ALQUILO(C1-C7), CARBOXIL-ALQUILO(C1-C7), ENTRE OTROS; R3 ES H O ALQUILO(C1-C7); R4 ES PIRIDILO, PIRAZINILO, PIRIMIDINILO, ENTRE OTROS; R5 ES H O METILO; n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 3-(2-CLORO-4-METOXI-FENIL)-1,1,1-TRIFLUOR-2-(5-METIL-PIRAZIN-2-IL)-BUTAN-2-OL, 1,1,1-TRIFLUOR-2-(2-METIL-PIRIDIN-4-IL)-3-FENIL-BUTAN-2-OL, 3-(2,4-DICLORO-FENIL)-1,1,1-TRIFLUOR-2-PIRIDIN-3-IL-BUTAN-2-OL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE GLUCOCORTICOIDE SIENDO UTILES EN EL TRATAMIENTO DE LA DIABETES
PE2008001670A 2007-09-27 2008-09-25 Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano PE20090741A1 (es)

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EP07117360 2007-09-27

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US (2) US8143280B2 (es)
EP (1) EP2205562B1 (es)
JP (1) JP5242691B2 (es)
KR (1) KR101174982B1 (es)
CN (1) CN101808992B (es)
AR (1) AR068635A1 (es)
AT (1) ATE502012T1 (es)
AU (1) AU2008303600B8 (es)
BR (1) BRPI0817242A8 (es)
CA (1) CA2700277A1 (es)
CL (1) CL2008002863A1 (es)
DE (1) DE602008005634D1 (es)
DK (1) DK2205562T3 (es)
ES (1) ES2360272T3 (es)
IL (1) IL204052A (es)
MX (1) MX2010002893A (es)
PE (1) PE20090741A1 (es)
PL (1) PL2205562T3 (es)
PT (1) PT2205562E (es)
RU (1) RU2481333C2 (es)
TW (1) TWI426904B (es)
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ES2360272T3 (es) 2011-06-02
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DE602008005634D1 (de) 2011-04-28
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CN101808992A (zh) 2010-08-18
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US20090088425A1 (en) 2009-04-02
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