PE20090741A1 - Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano - Google Patents

Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano

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Publication number
PE20090741A1
PE20090741A1 PE2008001670A PE2008001670A PE20090741A1 PE 20090741 A1 PE20090741 A1 PE 20090741A1 PE 2008001670 A PE2008001670 A PE 2008001670A PE 2008001670 A PE2008001670 A PE 2008001670A PE 20090741 A1 PE20090741 A1 PE 20090741A1
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PE
Peru
Prior art keywords
trifluor
alkyl
hydroxy
phenylpropane
butan
Prior art date
Application number
PE2008001670A
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English (en)
Inventor
Jacques Bailly
Cornelia Hertel
Daniel Hunziker
Christian Lerner
Ulrike Bost Sander
Jens-Uwe Peters
Philippe Pflieger
Tanja Schulz-Gasch
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Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090741A1 publication Critical patent/PE20090741A1/es

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    • C07D241/12Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P3/06Antihyperlipidemics
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  • Pyridine Compounds (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 1,1,1-TRIFLUOR-2-HIDROXI-3-FENILPROPANO DE FORMULA (I) DONDE A ES C-R1b O N; R1a, R1b, R1c, R1d Y R1e SON CADA UNO H, ALQUILO(C1-C7), CICLOALQUIL(C3-C7)-ALQUILO(C1-C7), HALOGENO, HIDROXI, ENTRE OTROS; R2 ES ALQUILO(C1-C7), CICLOALQUIL(C3-C7)-ALQUILO(C1-C7), CARBOXIL-ALQUILO(C1-C7), ENTRE OTROS; R3 ES H O ALQUILO(C1-C7); R4 ES PIRIDILO, PIRAZINILO, PIRIMIDINILO, ENTRE OTROS; R5 ES H O METILO; n ES 0 O 1. SON COMPUESTOS PREFERIDOS: 3-(2-CLORO-4-METOXI-FENIL)-1,1,1-TRIFLUOR-2-(5-METIL-PIRAZIN-2-IL)-BUTAN-2-OL, 1,1,1-TRIFLUOR-2-(2-METIL-PIRIDIN-4-IL)-3-FENIL-BUTAN-2-OL, 3-(2,4-DICLORO-FENIL)-1,1,1-TRIFLUOR-2-PIRIDIN-3-IL-BUTAN-2-OL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE GLUCOCORTICOIDE SIENDO UTILES EN EL TRATAMIENTO DE LA DIABETES
PE2008001670A 2007-09-27 2008-09-25 Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano PE20090741A1 (es)

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US (2) US8143280B2 (es)
EP (1) EP2205562B1 (es)
JP (1) JP5242691B2 (es)
KR (1) KR101174982B1 (es)
CN (1) CN101808992B (es)
AR (1) AR068635A1 (es)
AT (1) ATE502012T1 (es)
AU (1) AU2008303600B8 (es)
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CL (1) CL2008002863A1 (es)
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MX (1) MX2010002893A (es)
PE (1) PE20090741A1 (es)
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