AR065850A1 - Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph - Google Patents

Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph

Info

Publication number
AR065850A1
AR065850A1 ARP080101237A ARP080101237A AR065850A1 AR 065850 A1 AR065850 A1 AR 065850A1 AR P080101237 A ARP080101237 A AR P080101237A AR P080101237 A ARP080101237 A AR P080101237A AR 065850 A1 AR065850 A1 AR 065850A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
control agent
solid pharmaceutical
benzimidazol
salt
Prior art date
Application number
ARP080101237A
Other languages
English (en)
Inventor
Shuji Yoneyama
Yutaca Tanoue
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39590787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR065850(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR065850A1 publication Critical patent/AR065850A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composicion farmacéutica solida que contiene el compuesto (1) el cual ejerce una accion antagonica del receptor de angiotensina II y un agente de control del pH. La composicion es superior en términos de la estabilidad y propiedad de disolucion delcompuesto (i) Reivindicacion 1: Una composicion farmacéutica solida caracterizada porque comprende un compuesto representado por la formula (i) en la cual R1 es un grupo heterocíclico que contiene nitrogeno monocíclico con un átomo de hidrogeno quepuede ser desprotonizado, R2 es un grupo carboxílico esterificado y R3 es un alquilo inferior opcionalmente sustituido, o una sal del mismo, y un agente de control del pH. Reivindicacion 2: La composicion farmacéutica de la Reivindicacion 1,caracterizada porque la sal del compuesto representado por la formula (I) es una sal de potasio de (5-metil-2-oxo-1,3-dioxol-4-il) metil 2-etoxi-1-{[2'-(5-oxo-4,5-dihidro-1,2,4-oxadiazol-3-il)bifenil-4-il]-1H-benzimidazol-7-carboxilato. Reivindicacion 4: La composicion farmacéutica de la Reivindicacion 3 caracterizada porque el agente de control del pH es un fumarato monosodico o una combinacion de ácido fumárico e hidroxido de sodio.
ARP080101237A 2007-03-28 2008-03-26 Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph AR065850A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90851507P 2007-03-28 2007-03-28

Publications (1)

Publication Number Publication Date
AR065850A1 true AR065850A1 (es) 2009-07-08

Family

ID=39590787

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101237A AR065850A1 (es) 2007-03-28 2008-03-26 Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph

Country Status (19)

Country Link
US (1) US9066936B2 (es)
EP (1) EP2124903B1 (es)
JP (1) JP5283632B2 (es)
KR (1) KR20090125846A (es)
CN (1) CN101677961B (es)
AR (1) AR065850A1 (es)
AU (1) AU2008235790B2 (es)
BR (1) BRPI0809522A2 (es)
CA (1) CA2681143C (es)
CL (1) CL2008000868A1 (es)
EA (1) EA016593B1 (es)
ES (1) ES2743784T3 (es)
IL (1) IL201188A0 (es)
MX (1) MX2009010167A (es)
NZ (1) NZ579851A (es)
PE (2) PE20130210A1 (es)
PT (1) PT2124903T (es)
TW (1) TWI415634B (es)
WO (1) WO2008123536A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732018C (en) 2008-07-31 2017-07-04 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition
AR073380A1 (es) * 2008-09-25 2010-11-03 Takeda Pharmaceutical Composicion farmaceutica solida. comprimido multicapa
CN103096878B (zh) * 2011-05-23 2015-06-17 江苏恒瑞医药股份有限公司 包含苯并咪唑衍生物的固体药物组合物
CN102351853B (zh) * 2011-08-29 2014-03-12 石药集团欧意药业有限公司 一种阿齐沙坦酯化合物、制备方法及其药物组合物
HUE032635T2 (en) 2012-09-19 2017-10-30 Taiho Pharmaceutical Co Ltd For oral administration of pharmaceutical compositions having improved elution and / or absorbance
EP2928468A4 (en) 2012-12-05 2016-07-27 Sawai Seiyaku Kk PREPARATION CONTAINING CANDÉSARTAN CILEXÉTIL
WO2014102628A1 (en) 2012-12-31 2014-07-03 Ranbaxy Laboratories Limited Stable pharmaceutical composition comprising azilsartan medoxomil
EP2952187A4 (en) 2013-01-30 2016-08-17 Sawai Seiyaku Kk PHARMACEUTICAL COMPOSITION WITH CANDESARTAN CILEXETIL
CN105079815A (zh) * 2014-04-30 2015-11-25 广东东阳光药业有限公司 一种阿齐沙坦酯钾组合物及其制备方法
IN201721047406A (es) 2017-12-30 2020-06-19 Lupin Limited
IN202021028444A (es) * 2020-07-03 2022-01-28
CN117122570B (zh) * 2022-05-19 2024-04-09 北京阳光诺和药物研究股份有限公司 一种提高稳定性的美阿沙坦钾片及其制备方法
WO2024109927A1 (zh) * 2022-11-24 2024-05-30 上海云晟研新生物科技有限公司 包含美阿沙坦钾与钙通道阻滞剂的药物组合物，及其制备方法及应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US6004989A (en) * 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
TW284688B (es) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
US5605919A (en) * 1993-02-26 1997-02-25 Takeda Chemical Industries, Ltd. Treatment for viral diseases
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
KR19990087076A (ko) * 1996-04-05 1999-12-15 다께다 구니오 안지오텐신 ⅱ 및 길항 활성을 갖는 화합물을 함유하는 약제학적 배합물
IL137979A0 (en) * 1998-03-04 2001-10-31 Takeda Chemical Industries Ltd Production, release preparation for aii antagonist-sustained and use thereof
AU2573800A (en) * 1999-02-19 2000-09-04 Takeda Chemical Industries Ltd. Percutaneous absorption preparations of compound having angiotensin ii receptor antagonism
WO2000066161A1 (fr) * 1999-04-28 2000-11-09 Takeda Chemical Industries, Ltd. Preventifs / remedes / inhibiteurs de progression pour retinopathie simplex ou retinopathie preproliferante
DE60037192T2 (de) * 1999-07-21 2008-05-15 Takeda Pharmaceutical Co. Ltd. Mittel zur verbesserung der erkrankungen nach zerebralen durchblutungsstörungen sowie zur verhinderung deren fortschreitens
WO2001060362A1 (en) * 2000-02-18 2001-08-23 Takeda Chemical Industries, Ltd. TNF-α INHIBITORS
JP2001316296A (ja) * 2000-02-21 2001-11-13 Takeda Chem Ind Ltd 水に難溶性の生理活性化合物の徐放性製剤、その製造法および用途
AU2001232348A1 (en) * 2000-02-21 2001-08-27 Takeda Chemical Industries Ltd. Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same
WO2003041739A1 (en) * 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
AU2002349673A1 (en) * 2001-12-03 2003-06-17 Takeda Chemical Industries, Ltd. Insulin resistance improving agents
JP4484427B2 (ja) * 2001-12-03 2010-06-16 武田薬品工業株式会社 インスリン抵抗性改善剤
KR101092279B1 (ko) * 2002-12-27 2011-12-13 다케다 야쿠힌 고교 가부시키가이샤 체중 증가 억제제
WO2004082679A1 (ja) * 2003-03-17 2004-09-30 Takeda Pharmaceutical Company Limited 放出制御組成物
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
WO2005117591A2 (en) * 2004-05-28 2005-12-15 Andrx Labs Llc Novel pharmaceutical formulation containing a biguanide and an angiotensin antagonist
US20080004320A1 (en) * 2004-09-06 2008-01-03 Kowa Co., Ltd. Remedy for Glomerular Disease
US20060159747A1 (en) 2004-12-17 2006-07-20 Boehringer Ingelheim International Gmbh Telmisartan and hydrochlorothiazide combination therapy
WO2006124713A2 (en) * 2005-05-13 2006-11-23 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
US20080279942A1 (en) * 2005-06-27 2008-11-13 Takeshi Hamaura Pharmaceutical Preparation Containing an Angiotensin II Receptor Antagonist and a Calcium Channel Blocker
DE102005031577A1 (de) 2005-07-06 2007-01-11 Bayer Healthcare Ag Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
TWI494134B (zh) 2006-06-20 2015-08-01 Siegfried Generics Int Ag 含有坎地沙坦酯的組成物、錠劑和顆粒及該錠劑的製造方法
WO2008045006A1 (en) * 2006-10-11 2008-04-17 Fako Ilaclari A. S. Formulations of candesartan
WO2008068217A2 (en) 2006-12-04 2008-06-12 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a coated hmg-coa reductase inhibitor and an inhibitor of the renin-angiotensin system
US9387249B2 (en) * 2008-12-23 2016-07-12 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone

Also Published As

Publication number Publication date
KR20090125846A (ko) 2009-12-07
US9066936B2 (en) 2015-06-30
PE20130210A1 (es) 2013-03-11
US20100121071A1 (en) 2010-05-13
EP2124903A1 (en) 2009-12-02
TWI415634B (zh) 2013-11-21
PT2124903T (pt) 2019-09-26
WO2008123536A1 (en) 2008-10-16
ES2743784T3 (es) 2020-02-20
CA2681143A1 (en) 2008-10-16
TW200902089A (en) 2009-01-16
EA016593B1 (ru) 2012-06-29
NZ579851A (en) 2012-02-24
BRPI0809522A2 (pt) 2014-10-14
JP2010522692A (ja) 2010-07-08
JP5283632B2 (ja) 2013-09-04
CL2008000868A1 (es) 2008-10-10
MX2009010167A (es) 2009-10-12
EA200970896A1 (ru) 2010-04-30
AU2008235790A1 (en) 2008-10-16
CA2681143C (en) 2017-01-03
EP2124903B1 (en) 2019-06-12
CN101677961A (zh) 2010-03-24
IL201188A0 (en) 2010-05-17
CN101677961B (zh) 2012-10-17
PE20090550A1 (es) 2009-06-01
AU2008235790B2 (en) 2013-06-06

Similar Documents

Publication Publication Date Title
AR065850A1 (es) Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph
AR112118A2 (es) Inhibidores de pi-3 quinasa
PE20081228A1 (es) Compuesto heteromonociclico
AR073380A1 (es) Composicion farmaceutica solida. comprimido multicapa
AR079550A1 (es) Derivados de pirazol
NZ594597A (en) Substituted piperidines as ccr3 antagonists
PE20081800A1 (es) NUEVOS DERIVADOS DE 3-([1,2,4]TRIAZOLO[4,3-a]PIRIDIN-7-IL)BENZAMIDA
PE20141827A1 (es) Inhibidores de proteinas quinasas
PE20060691A1 (es) Serinamidas sustituidas por benzoilo
PE20060298A1 (es) Derivados de acido carboxilico de bencimidazolona
CO6270320A2 (es) Derivados de piperidina utiles como antagonistas del receptor orexina
PE20080538A1 (es) Derivado heterociclico fusionado y su uso
PE20110835A1 (es) Piridiloxi-indoles inhibidores del vegf-r2 y uso de los mismos para el tratamiento de enfermedades
PE20110028A1 (es) Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato
TW200640879A (en) Amide derivatives
AR063529A1 (es) Compuestos de pirazolina
PE20140934A1 (es) Derivados de pirazol
RS20080510A (en) Benzimidazole derivative and use as angiotensin ii antagonist
PE20060729A1 (es) Compuestos heterociclicos como moduladores o inhibidores de la actividad de miostatina
PE20071337A1 (es) Nanoparticulas que comprenden imatinib, composiciones farmaceuticas y dispositivos que comprenden dichas nanoparticulas y uso farmaceutico de las mismas
PE20120315A1 (es) Una composicion farmaceutica que comprende candesartan, candesartan cilexetil, o azilsartan, combinado con amlodipino
PE20141169A1 (es) Derivados de etinilo
PE20081665A1 (es) Antagonistas del receptor de dopamina 2 de rapida disociacion
CO6612226A2 (es) Tableta
PE20071149A1 (es) Derivados de benzimidazol

Legal Events

Date Code Title Description
FA Abandonment or withdrawal