ATE204276T1 - Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung - Google Patents
Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendungInfo
- Publication number
- ATE204276T1 ATE204276T1 AT93120135T AT93120135T ATE204276T1 AT E204276 T1 ATE204276 T1 AT E204276T1 AT 93120135 T AT93120135 T AT 93120135T AT 93120135 T AT93120135 T AT 93120135T AT E204276 T1 ATE204276 T1 AT E204276T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- group
- stands
- optionally
- optionally substituted
- Prior art date
Links
- 102000005862 Angiotensin II Human genes 0.000 title abstract 2
- 101800000733 Angiotensin-2 Proteins 0.000 title abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 2
- 229950006323 angiotensin ii Drugs 0.000 title abstract 2
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34291792 | 1992-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204276T1 true ATE204276T1 (de) | 2001-09-15 |
Family
ID=18357523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93120135T ATE204276T1 (de) | 1992-12-22 | 1993-12-14 | Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5496835A (de) |
| EP (1) | EP0603712B1 (de) |
| AT (1) | ATE204276T1 (de) |
| CA (1) | CA2112050A1 (de) |
| DE (1) | DE69330593T2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2115985A1 (en) * | 1993-02-25 | 1994-08-26 | Kohei Nishikawa | Vascular hypertrophy suppressor |
| JP3810020B2 (ja) | 1993-04-22 | 2006-08-16 | 武田薬品工業株式会社 | 腎疾患の予防または治療剤 |
| CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
| US6297198B1 (en) | 1996-05-14 | 2001-10-02 | Syngenta Participations Ag | Isoxazole derivatives and their use as herbicides |
| IL137979A0 (en) | 1998-03-04 | 2001-10-31 | Takeda Chemical Industries Ltd | Production, release preparation for aii antagonist-sustained and use thereof |
| US7812044B2 (en) | 2001-11-13 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Anticancer agents |
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| EP1917245A1 (de) | 2005-08-21 | 2008-05-07 | Abbott GmbH & Co. KG | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| JP2010510962A (ja) | 2006-11-24 | 2010-04-08 | 武田薬品工業株式会社 | 複素単環化合物およびその用途 |
| US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| EP2065184B1 (de) | 2007-11-27 | 2015-08-26 | La Seda De Barcelona S.A. | Durchsichtiger mehrschichtiger Spritzgussbehälter mit Fluorpolymersperrschicht |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5104891A (en) * | 1989-12-11 | 1992-04-14 | G. D. Searle & Co. | Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension |
| GB9005354D0 (en) * | 1990-03-09 | 1990-05-02 | Glaxo Group Ltd | Chemical compounds |
| IE910913A1 (en) * | 1990-03-20 | 1991-09-25 | Sanofi Sa | N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them |
| CA2079343A1 (en) * | 1990-03-30 | 1991-10-01 | Eric E. Allen | Substituted pyrazoles, isoxazoles and isothiazoles |
| JPH05505609A (ja) * | 1990-03-30 | 1993-08-19 | メルク・エンド・カムパニー・インコーポレーテツド | 置換ピリミジン、ピリミジノンおよびピリドリミジン |
| AU636066B2 (en) * | 1990-10-30 | 1993-04-08 | Takeda Chemical Industries Ltd. | Thienoimidazole derivatives, their production and use |
| FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
| EP0503838A3 (en) * | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| US5157040A (en) * | 1991-04-05 | 1992-10-20 | Merck & Co., Inc. | Substituted quinolines as angiotensin ii antagonists |
| FR2677984B1 (fr) * | 1991-06-21 | 1994-02-25 | Elf Sanofi | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
| IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them |
-
1993
- 1993-12-14 AT AT93120135T patent/ATE204276T1/de active
- 1993-12-14 EP EP93120135A patent/EP0603712B1/de not_active Expired - Lifetime
- 1993-12-14 DE DE69330593T patent/DE69330593T2/de not_active Expired - Fee Related
- 1993-12-21 CA CA002112050A patent/CA2112050A1/en not_active Abandoned
- 1993-12-22 US US08/171,164 patent/US5496835A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0603712A3 (en) | 1994-07-13 |
| DE69330593D1 (de) | 2001-09-20 |
| EP0603712A2 (de) | 1994-06-29 |
| US5496835A (en) | 1996-03-05 |
| CA2112050A1 (en) | 1994-06-23 |
| EP0603712B1 (de) | 2001-08-16 |
| DE69330593T2 (de) | 2002-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0906907T3 (da) | Forbindelser, der potenserer retinoid | |
| DE3851073D1 (de) | Herbizide substituierte cyclische Dione. | |
| DE60124504D1 (de) | Stabile emulsionszubereitungen | |
| DE69328975D1 (de) | Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten | |
| ATE126219T1 (de) | Benzimidazolderivate, verfahren zu deren herstellung und anwendung. | |
| DK0546358T3 (da) | Farmaceutiske præparater med angiotensin-II-antagonistisk aktivitet | |
| DE69736642D1 (de) | Heterocyclische Verbindungen, ihre Herstellung und Verwendung | |
| DE69108138D1 (de) | Imidazopyridinderivate und ihre Verwendung. | |
| ATE204276T1 (de) | Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung | |
| ATE239720T1 (de) | Heterozyklische verbindungen | |
| BR9506482A (pt) | Aril e heteroaril pirimidinas herbicidas | |
| ATE164844T1 (de) | Azolverbindungen, ihre herstellung und verwendung als antimykotische mittel | |
| EA200200537A1 (ru) | Оксимные о-эфирные соединения и фунгициды для применения в земледелии и садоводстве | |
| ATE214059T1 (de) | 4,6-di-t-butyl-2,3-dihydrobenzothiophene, die ldl oxidation hemmen | |
| MY125037A (en) | 1,2,3,4 tetrahydroquinoline derivatives | |
| ATE168679T1 (de) | Neue tetracyclische verbindungen | |
| SE8303913L (sv) | Heterocykliska foreningar | |
| ATE102620T1 (de) | 1-chlor-1-azolyl-methyloxirane und diese enthaltende fungizide. | |
| DE69430766D1 (de) | Vasculäre Hypertrophicsuppressor | |
| ATE27455T1 (de) | Heterocyclische guanidino-phenylamidine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. | |
| ATE125669T1 (de) | Fungizide verbindungen und zusammensetzungen, die tris(aryl)-phosphonium salze enthalten. | |
| DE58900084D1 (de) | Azolylmethylcyclopropane und ihre verwendung als pflanzenschutzmittel. | |
| DE3766863D1 (de) | Fungizide. | |
| FI944207A0 (fi) | Cyclohexane derivatives | |
| EP0781773A4 (de) | Neue carbapenem-derivate |