CA2112050A1 - Heterocyclic compounds having angiotensin ii antagonistic activity and use thereof - Google Patents

Heterocyclic compounds having angiotensin ii antagonistic activity and use thereof

Info

Publication number
CA2112050A1
CA2112050A1 CA002112050A CA2112050A CA2112050A1 CA 2112050 A1 CA2112050 A1 CA 2112050A1 CA 002112050 A CA002112050 A CA 002112050A CA 2112050 A CA2112050 A CA 2112050A CA 2112050 A1 CA2112050 A1 CA 2112050A1
Authority
CA
Canada
Prior art keywords
group
compound
optionally substituted
compound according
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002112050A
Other languages
English (en)
French (fr)
Inventor
Keiji Kubo
Yoshiyuki Inada
Takehiko Naka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CA2112050A1 publication Critical patent/CA2112050A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002112050A 1992-12-22 1993-12-21 Heterocyclic compounds having angiotensin ii antagonistic activity and use thereof Abandoned CA2112050A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34291792 1992-12-22
JP342917/1992 1992-12-22

Publications (1)

Publication Number Publication Date
CA2112050A1 true CA2112050A1 (en) 1994-06-23

Family

ID=18357523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002112050A Abandoned CA2112050A1 (en) 1992-12-22 1993-12-21 Heterocyclic compounds having angiotensin ii antagonistic activity and use thereof

Country Status (5)

Country Link
US (1) US5496835A (de)
EP (1) EP0603712B1 (de)
AT (1) ATE204276T1 (de)
CA (1) CA2112050A1 (de)
DE (1) DE69330593T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
US6297198B1 (en) 1996-05-14 2001-10-02 Syngenta Participations Ag Isoxazole derivatives and their use as herbicides
IL137979A0 (en) 1998-03-04 2001-10-31 Takeda Chemical Industries Ltd Production, release preparation for aii antagonist-sustained and use thereof
WO2003041739A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
US7803940B2 (en) * 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
US20080207654A1 (en) 2006-11-24 2008-08-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
ES2553089T3 (es) 2007-11-27 2015-12-04 La Seda De Barcelona S.A. Recipiente moldeado por inyección multicapa transparente que tiene una capa de barrera de fluoropolímero

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104891A (en) * 1989-12-11 1992-04-14 G. D. Searle & Co. Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
IE910913A1 (en) * 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
JPH05505609A (ja) * 1990-03-30 1993-08-19 メルク・エンド・カムパニー・インコーポレーテツド 置換ピリミジン、ピリミジノンおよびピリドリミジン
EP0523141A4 (en) * 1990-03-30 1993-04-21 Merck & Co. Inc. Substituted pyrazoles, isoxazoles and isothiazoles
AU636066B2 (en) * 1990-10-30 1993-04-08 Takeda Chemical Industries Ltd. Thienoimidazole derivatives, their production and use
FR2673427B1 (fr) * 1991-03-01 1993-06-18 Sanofi Elf Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
EP0503838A3 (en) * 1991-03-08 1992-10-07 Merck & Co. Inc. Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists
FR2677984B1 (fr) * 1991-06-21 1994-02-25 Elf Sanofi Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0603712A3 (en) 1994-07-13
ATE204276T1 (de) 2001-09-15
EP0603712A2 (de) 1994-06-29
DE69330593D1 (de) 2001-09-20
DE69330593T2 (de) 2002-06-27
EP0603712B1 (de) 2001-08-16
US5496835A (en) 1996-03-05

Similar Documents

Publication Publication Date Title
US5243054A (en) Compound which is angiotensin ii antagonist
US5389641A (en) Fused heterocyclic compounds, having angiotensin II antagonistic activity
US5705517A (en) Benzimidazole derivatives and use thereof
CA2032831A1 (en) Fused imidazole derivatives, their production and use
US5703110A (en) Benzimidazole derivatives, their production and use
AU636066B2 (en) Thienoimidazole derivatives, their production and use
US6232334B1 (en) Benzimidazole derivatives, their production and use
US5500427A (en) Cyclic compounds and their use
US5496835A (en) Heterocyclic compounds having angiotensin II antagonistic activity and use thereof
JP3003030B2 (ja) アミノベンゼン化合物の製造法
JP3412887B2 (ja) アンギオテンシンｉｉ拮抗作用を有する複素環化合物およびその用途
RU2168510C2 (ru) Гетероциклическое соединение, фармацевтическая композиция, способ антагонизирования ангиотензина ii
RU2104276C1 (ru) Гетероциклические соединения, фармацевтическая композиция, проявляющая активность антагониста ангиотензина ii и способ антагонизирования ангиотензина ii у млекопитающих
JP3032844B2 (ja) ピリミジンジオン誘導体
JPH06239859A (ja) アンギオテンシンｉｉ拮抗作用を有する環状化合物およびその用途
RU2144022C1 (ru) Эфиры n-(бифенилметил)аминобензойной кислоты и способ их получения

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued