BR0312798A - Derivados de isotiazol úteis como agentes anticancerìgenos - Google Patents

Derivados de isotiazol úteis como agentes anticancerìgenos

Info

Publication number
BR0312798A
BR0312798A BR0312798-2A BR0312798A BR0312798A BR 0312798 A BR0312798 A BR 0312798A BR 0312798 A BR0312798 A BR 0312798A BR 0312798 A BR0312798 A BR 0312798A
Authority
BR
Brazil
Prior art keywords
anticancer agents
derivatives useful
formula
compounds
isothiazole derivatives
Prior art date
Application number
BR0312798-2A
Other languages
English (en)
Inventor
Tricia Ann Kwan
Susan Deborah Lagreca
Blaise Scott Lippa
Joel Morris
Matthew David Wessel
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0312798A publication Critical patent/BR0312798A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE ISOTIAZOL úTEIS COMO AGENTES ANTICANCERìGENOS". A presente invenção refere-se a compostos de fórmula 1 ou aos seus sais, pró-drogas, solvatos ou hidratos farmaceuticamente aceitáveis em que X, R^ 1^, e R^ 2^ são tal como aqui definidos. A invenção também refere-se a composições farmacêuticas contendo os compostos de fórmula 1 e a métodos de tratamento de distúrbios hiperproliferativos em um mamífero pela administração de compostos de fórmula 1.
BR0312798-2A 2002-07-25 2003-07-14 Derivados de isotiazol úteis como agentes anticancerìgenos BR0312798A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39838602P 2002-07-25 2002-07-25
PCT/IB2003/003161 WO2004011461A1 (en) 2002-07-25 2003-07-14 Isothiazole derivatives useful as anticancer agents

Publications (1)

Publication Number Publication Date
BR0312798A true BR0312798A (pt) 2005-05-03

Family

ID=31188391

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312798-2A BR0312798A (pt) 2002-07-25 2003-07-14 Derivados de isotiazol úteis como agentes anticancerìgenos

Country Status (8)

Country Link
US (1) US7276602B2 (pt)
EP (1) EP1527071A1 (pt)
JP (1) JP4511352B2 (pt)
AU (1) AU2003281664A1 (pt)
BR (1) BR0312798A (pt)
CA (1) CA2493701A1 (pt)
MX (1) MXPA05000950A (pt)
WO (1) WO2004011461A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2349588C2 (ru) 2004-08-26 2009-03-20 Пфайзер Продактс Инк. Способы получения производных изотиазола
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
US7842836B2 (en) 2006-04-11 2010-11-30 Ardea Biosciences N-aryl-N'alkyl sulfamides as MEK inhibitors
CN101454004B (zh) * 2006-04-18 2013-12-04 阿迪亚生命科学公司 作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类
US8509487B2 (en) * 2007-04-19 2013-08-13 Avago Technologies General Ip (Singapore) Pte. Ltd. System and method for optically measuring a parameter of an object
WO2010011375A2 (en) 2008-04-21 2010-01-28 Merck & Co., Inc. Inhibitors of janus kinases
EP2791139B1 (en) 2011-12-12 2017-11-08 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic compounds as tropomyosin receptor kinase a (trka) inhibitors
CN102944674B (zh) * 2012-11-05 2014-10-22 武汉远征世纪制药有限公司 一种检测TrkB受体pan-Tyr位点活性的ELISA试剂盒及其使用方法
BR112015021334B1 (pt) 2013-03-14 2020-04-07 Panoptica Inc formulação ocular tópica em suspenão e uso da mesma para tratamento e/ou melhora de uma doença do segmento posterior do olho
US9394305B2 (en) 2014-06-23 2016-07-19 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds as tropomyosin receptor kinase a (TrkA) inhibitors
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2020245208A1 (en) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023193809A1 (zh) * 2022-04-08 2023-10-12 深圳众格生物科技有限公司 Sarm1抑制剂化合物、包含其的药物组合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69222637T2 (de) 1991-05-10 1998-02-26 Rhone Poulenc Rorer Int Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase
IL112721A0 (en) * 1994-03-10 1995-05-26 Zeneca Ltd Azole derivatives
GEP20032896B (en) 1997-10-27 2003-02-25 Agouron Pharma 4-Aminothiazole Derivatives, Containing Them Pharmaceutical Compositions Inhibiting Cyclin-Dependent Kinases and Methods for Treatment
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
ES2271086T3 (es) * 2000-11-28 2007-04-16 Pfizer Products Inc. Sales de una isotiazol-4-carboxamida y su uso como agentes de antihiperproliferacion.

Also Published As

Publication number Publication date
WO2004011461A1 (en) 2004-02-05
MXPA05000950A (es) 2005-05-16
JP4511352B2 (ja) 2010-07-28
US7276602B2 (en) 2007-10-02
AU2003281664A1 (en) 2004-02-16
JP2005536523A (ja) 2005-12-02
CA2493701A1 (en) 2004-02-05
US20040152691A1 (en) 2004-08-05
EP1527071A1 (en) 2005-05-04

Similar Documents

Publication Publication Date Title
BR0111377A (pt) Derivados de tiofeno úteis como agentes anticancerìgenos
BR0311806A (pt) Derivados heteroaril benzocondensado-amida de tienopiridinas úteis como agentes terapêuticos, composições farmacêuticas que os incluem e métodos para o seu uso
RS20080533A (en) Triazolopyrazine derivatives useful as anticancer agents
BR0312798A (pt) Derivados de isotiazol úteis como agentes anticancerìgenos
BRPI0414011A (pt) naftalencarboxamidas e seus derivados úteis como novos agentes antiangiogênicos
BR0010746A (pt) Derivados heterocìclicos úteis com agentes anticâncer
BR9910900A (pt) Derivados isotiazol úteis como agentes anticancerìgenos
BR9814018A (pt) Derivados de tienopirimidina e tienopiridina úteis como agentes anticâncer
RS20050469A (en) Pyrrolopyrimidine derivatives
BG105365A (en) Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents
BRPI0418102A (pt) derivados de quinolina
BR0110267A (pt) Inibidores de dipeptidil peptidase iv
BRPI0518651A2 (pt) composto, uma prà-droga do mesmo, ou um sal do composto ou prà-droga farmaceuticamente aceitÁvel, composiÇço farmacÊutica, inibidor de dipeptidil peptidase iv, uso de um composto, uma prà-droga do mesmo ou um sal do composto ou prà-droga farmaceuticamente aceitÁvel, e, mÉtodo para tratar diabetes
MXPA06002296A (es) Tienopiridina-fenilacetamidas y sus derivados utiles como nuevos agentes antiangiogenicos.
WO2007138472A3 (en) Triazolopyridazine derivatives
BRPI0416656A (pt) compostos de pirrolopirimidina úteis no tratamento do cáncer
BRPI0718966B8 (pt) composto, composição farmacêutica, inibidor plk1 e agente antitumoral
BR9805734A (pt) Derivados de imidazolin-4-ona úteis como agentes anticancerìgenos.
BRPI0518231A2 (pt) derivados de 2-amido-4-feniltiazol, o respectivo preparo e a respectiva aplicaÇço em terapÊutica
UA94606C2 (ru) Производные тиоксантина, композиция, которая их содержит, и их применение в терапии
BR0308162A (pt) Derivados de indolil-uréia de tienopiridinas úteis como agentes antiangiogênicos e métodos para o seu uso
BRPI0310032B8 (pt) derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica
TW200716547A (en) Piperidin-4-yl-amide derivatives
PL1682528T3 (pl) Pochodne benzo[b][1,4]dioksepiny
BR0313727A (pt) Derivados de isoquinolina como inibidores de metaloproteinase da matriz

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010.