DK0674624T3 - Pyrazoler med CRF-antagonistisk aktivitet - Google Patents
Pyrazoler med CRF-antagonistisk aktivitetInfo
- Publication number
- DK0674624T3 DK0674624T3 DK93925103T DK93925103T DK0674624T3 DK 0674624 T3 DK0674624 T3 DK 0674624T3 DK 93925103 T DK93925103 T DK 93925103T DK 93925103 T DK93925103 T DK 93925103T DK 0674624 T3 DK0674624 T3 DK 0674624T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pyrazoles
- antagonistic activity
- date jun
- crf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99222592A | 1992-12-17 | 1992-12-17 | |
PCT/US1993/010359 WO1994013643A1 (en) | 1992-12-17 | 1993-11-03 | Pyrazoles and pyrazolopyrimidines having crf antagonist activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0674624T3 true DK0674624T3 (da) | 1999-09-13 |
Family
ID=25538063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93925103T DK0674624T3 (da) | 1992-12-17 | 1993-11-03 | Pyrazoler med CRF-antagonistisk aktivitet |
Country Status (27)
Country | Link |
---|---|
US (1) | US5712303A (da) |
EP (1) | EP0674624B1 (da) |
JP (1) | JP2862374B2 (da) |
KR (1) | KR0170567B1 (da) |
CN (1) | CN1060768C (da) |
AT (1) | ATE175961T1 (da) |
AU (1) | AU690527B2 (da) |
BR (1) | BR9307659A (da) |
CA (1) | CA2150483C (da) |
CZ (1) | CZ284157B6 (da) |
DE (1) | DE69323212T2 (da) |
DK (1) | DK0674624T3 (da) |
EG (1) | EG20397A (da) |
ES (1) | ES2126661T3 (da) |
FI (1) | FI113648B (da) |
GR (1) | GR3029568T3 (da) |
HU (1) | HUT67457A (da) |
IL (1) | IL107946A (da) |
MX (2) | MX9308042A (da) |
MY (1) | MY131382A (da) |
NO (2) | NO304831B1 (da) |
NZ (1) | NZ257770A (da) |
PL (1) | PL175831B1 (da) |
RU (1) | RU2142946C1 (da) |
TW (1) | TW238303B (da) |
WO (1) | WO1994013643A1 (da) |
ZA (1) | ZA939404B (da) |
Families Citing this family (82)
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US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
BR9407799A (pt) * | 1993-10-12 | 1997-05-06 | Du Pont Merck Pharma | Composição de matéria método de tratamento e composição farmaceutica |
US5646152A (en) * | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
DE69532817T2 (de) * | 1994-11-10 | 2005-01-13 | Millenium Pharmaceuticals, Inc., Cambridge | Verwendung von pyrazole verbindungen zur behandlung von glomerulonephritis, krebs, atherosklerose oder restenose |
EP0729758A3 (en) * | 1995-03-02 | 1997-10-29 | Pfizer | Pyrazolopyrimidines and pyrrolopyrimidines to treat neuronal disorders and other diseases |
US7125880B1 (en) | 1995-06-06 | 2006-10-24 | Pfizer Inc. | Corticotropin releasing factor antagonists |
US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
US5817688A (en) * | 1995-12-19 | 1998-10-06 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US5922885A (en) * | 1995-12-19 | 1999-07-13 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US6051578A (en) * | 1996-02-12 | 2000-04-18 | Pfizer Inc. | Pyrazolopyrimidines for treatment of CNS disorders |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US5760225A (en) * | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
EP0976745B1 (en) * | 1997-03-26 | 2003-08-13 | Taisho Pharmaceutical Co., Ltd | 4-tetrahydropyridylpyrimidine derivatives |
SE9701398D0 (sv) * | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
WO1999045007A1 (en) * | 1998-03-06 | 1999-09-10 | Janssen Pharmaceutica N.V. | Crf antagonistic pyrazolo[4,3-b]pyridines |
EP1068205A1 (en) | 1998-04-02 | 2001-01-17 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino 2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino 4,5-b]indole derivatives: crf1 specific ligands |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
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US6376527B1 (en) | 1998-05-05 | 2002-04-23 | Syntex (U.S.A.) Llc | Pyrazole derivatives-p38 map kinase inhibitors |
US20020156114A1 (en) | 1998-05-05 | 2002-10-24 | Goldstein David Michael | Pyrazole derivatives - p38 MAP kinase inhibitors |
ATE240958T1 (de) | 1998-11-12 | 2003-06-15 | Neurocrine Biosciences Inc | Crf rezeptor-antagonisten und darauf bezogene methoden |
CN1217945C (zh) | 1998-11-12 | 2005-09-07 | 纽罗克里恩生物科学有限公司 | Crf受体拮抗剂以及与其有关的方法 |
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PL213633B1 (pl) | 2002-10-22 | 2013-04-30 | Eisai R&D Management Co Ltd | Pochodne 7-fenylopirazolopirydyny, srodek terapeutyczny lub profilaktyczny i zastosowanie |
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RU2353358C2 (ru) | 2002-12-13 | 2009-04-27 | Уорнер-Ламберт Компани Ллс | Производные прегабалина для лечения приливов |
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KR101204247B1 (ko) | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도 |
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KR100820006B1 (ko) * | 2004-02-18 | 2008-04-08 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 gaba-a 아형 선택적 수용체 조절제 |
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US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
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EP2254420A4 (en) | 2008-02-20 | 2012-02-15 | Targia Pharmaceuticals | CNS PHARMACEUTICALS AND METHOD FOR THEIR USE |
WO2009128383A1 (ja) | 2008-04-15 | 2009-10-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 3-フェニルピラゾロ[5,1-b]チアゾール化合物 |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
AR084370A1 (es) | 2009-08-07 | 2013-05-15 | Chugai Pharmaceutical Co Ltd | Derivados de aminopirazol |
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DK3087986T3 (da) | 2013-12-27 | 2019-12-02 | Chugai Pharmaceutical Co Ltd | Mutant fgfr-gatekeepergen og aktivt stof rettet mod samme |
US10479780B2 (en) | 2015-06-17 | 2019-11-19 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives |
MX2018013221A (es) | 2016-04-29 | 2019-06-24 | Fgh Biotech Inc | Compuestos de pirazol disustituidos para el tratamiento de enfermedades. |
CN110072861B (zh) | 2016-09-07 | 2022-11-11 | Fgh生物科技公司 | 用于治疗疾病的二取代吡唑类化合物 |
EP3563848A1 (en) * | 2018-04-30 | 2019-11-06 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Serpin inhibitors for the treatment of prion and prion-like diseases |
CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
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FR2460299A1 (fr) * | 1979-07-05 | 1981-01-23 | Bellon Labor Sa Roger | Nouveaux derives du pyrazole et leur application therapeutique |
FR2472564A1 (fr) * | 1979-12-31 | 1981-07-03 | Bellon Labor Sa Roger | Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer |
DE3602728A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 51373 Leverkusen | Schaedlingsbekaempfungsmittel auf basis von pyrazolderivaten |
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1993
- 1993-11-03 NZ NZ257770A patent/NZ257770A/en unknown
- 1993-11-03 JP JP6514147A patent/JP2862374B2/ja not_active Expired - Lifetime
- 1993-11-03 AT AT93925103T patent/ATE175961T1/de not_active IP Right Cessation
- 1993-11-03 WO PCT/US1993/010359 patent/WO1994013643A1/en active IP Right Grant
- 1993-11-03 EP EP93925103A patent/EP0674624B1/en not_active Expired - Lifetime
- 1993-11-03 KR KR1019950702478A patent/KR0170567B1/ko not_active IP Right Cessation
- 1993-11-03 ES ES93925103T patent/ES2126661T3/es not_active Expired - Lifetime
- 1993-11-03 DK DK93925103T patent/DK0674624T3/da active
- 1993-11-03 CA CA002150483A patent/CA2150483C/en not_active Expired - Fee Related
- 1993-11-03 AU AU54548/94A patent/AU690527B2/en not_active Ceased
- 1993-11-03 PL PL93309356A patent/PL175831B1/pl unknown
- 1993-11-03 RU RU95113969/04A patent/RU2142946C1/ru not_active IP Right Cessation
- 1993-11-03 BR BR9307659A patent/BR9307659A/pt not_active Application Discontinuation
- 1993-11-03 US US08/448,529 patent/US5712303A/en not_active Expired - Fee Related
- 1993-11-03 DE DE69323212T patent/DE69323212T2/de not_active Expired - Fee Related
- 1993-11-03 CZ CZ951585A patent/CZ284157B6/cs not_active IP Right Cessation
- 1993-11-06 TW TW082109298A patent/TW238303B/zh active
- 1993-12-09 IL IL10794693A patent/IL107946A/en not_active IP Right Cessation
- 1993-12-10 MY MYPI93002669A patent/MY131382A/en unknown
- 1993-12-15 MX MX9308042A patent/MX9308042A/es unknown
- 1993-12-15 EG EG79593A patent/EG20397A/xx active
- 1993-12-15 HU HU9303591A patent/HUT67457A/hu not_active Application Discontinuation
- 1993-12-15 ZA ZA939404A patent/ZA939404B/xx unknown
- 1993-12-16 FI FI935674A patent/FI113648B/fi not_active IP Right Cessation
- 1993-12-16 CN CN93120120A patent/CN1060768C/zh not_active Expired - Fee Related
-
1995
- 1995-06-16 NO NO952395A patent/NO304831B1/no unknown
-
1998
- 1998-06-29 MX MXPA98005325A patent/MXPA98005325A/es unknown
- 1998-11-25 NO NO985494A patent/NO306111B1/no unknown
-
1999
- 1999-03-04 GR GR990400652T patent/GR3029568T3/el unknown
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