NO304831B1 - Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet - Google Patents
Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitetInfo
- Publication number
- NO304831B1 NO304831B1 NO952395A NO952395A NO304831B1 NO 304831 B1 NO304831 B1 NO 304831B1 NO 952395 A NO952395 A NO 952395A NO 952395 A NO952395 A NO 952395A NO 304831 B1 NO304831 B1 NO 304831B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- pyrazoles
- antagonist activity
- pyrazolopyrimidines
- crf antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99222592A | 1992-12-17 | 1992-12-17 | |
PCT/US1993/010359 WO1994013643A1 (en) | 1992-12-17 | 1993-11-03 | Pyrazoles and pyrazolopyrimidines having crf antagonist activity |
Publications (3)
Publication Number | Publication Date |
---|---|
NO952395D0 NO952395D0 (no) | 1995-06-16 |
NO952395L NO952395L (no) | 1995-08-16 |
NO304831B1 true NO304831B1 (no) | 1999-02-22 |
Family
ID=25538063
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO952395A NO304831B1 (no) | 1992-12-17 | 1995-06-16 | Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet |
NO985494A NO306111B1 (no) | 1992-12-17 | 1998-11-25 | Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO985494A NO306111B1 (no) | 1992-12-17 | 1998-11-25 | Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet |
Country Status (27)
Country | Link |
---|---|
US (1) | US5712303A (da) |
EP (1) | EP0674624B1 (da) |
JP (1) | JP2862374B2 (da) |
KR (1) | KR0170567B1 (da) |
CN (1) | CN1060768C (da) |
AT (1) | ATE175961T1 (da) |
AU (1) | AU690527B2 (da) |
BR (1) | BR9307659A (da) |
CA (1) | CA2150483C (da) |
CZ (1) | CZ284157B6 (da) |
DE (1) | DE69323212T2 (da) |
DK (1) | DK0674624T3 (da) |
EG (1) | EG20397A (da) |
ES (1) | ES2126661T3 (da) |
FI (1) | FI113648B (da) |
GR (1) | GR3029568T3 (da) |
HU (1) | HUT67457A (da) |
IL (1) | IL107946A (da) |
MX (2) | MX9308042A (da) |
MY (1) | MY131382A (da) |
NO (2) | NO304831B1 (da) |
NZ (1) | NZ257770A (da) |
PL (1) | PL175831B1 (da) |
RU (1) | RU2142946C1 (da) |
TW (1) | TW238303B (da) |
WO (1) | WO1994013643A1 (da) |
ZA (1) | ZA939404B (da) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
US6103900A (en) * | 1992-12-17 | 2000-08-15 | Pfizer Inc | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
PL313973A1 (en) * | 1993-10-12 | 1996-08-05 | Du Pont Merck Pharma | 1 n-alkyl-n-arylopyrimidin amines and their derivatives |
US5646152A (en) * | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
EP0788358B1 (en) * | 1994-11-10 | 2004-03-31 | Millennium Pharmaceuticals, Inc. | Use of pyrazole compounds for the treatment of glomerulonephritis, cancer, atherosclerosis or restenosis |
EP0729758A3 (en) * | 1995-03-02 | 1997-10-29 | Pfizer | Pyrazolopyrimidines and pyrrolopyrimidines to treat neuronal disorders and other diseases |
US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
US7067664B1 (en) | 1995-06-06 | 2006-06-27 | Pfizer Inc. | Corticotropin releasing factor antagonists |
US5817688A (en) * | 1995-12-19 | 1998-10-06 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US5922885A (en) * | 1995-12-19 | 1999-07-13 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US6051578A (en) * | 1996-02-12 | 2000-04-18 | Pfizer Inc. | Pyrazolopyrimidines for treatment of CNS disorders |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US5760225A (en) * | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
AU733604B2 (en) | 1997-03-26 | 2001-05-17 | Taisho Pharmaceutical Co., Ltd. | 4-tetrahydropyridylpyrimidine derivative |
SE9701398D0 (sv) * | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
US6613777B1 (en) | 1998-03-06 | 2003-09-02 | Chen Chen | CRF antagonistic pyrazolo[4,3-b]pyridines |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
CA2326319A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands |
US20020156114A1 (en) | 1998-05-05 | 2002-10-24 | Goldstein David Michael | Pyrazole derivatives - p38 MAP kinase inhibitors |
US6316466B1 (en) | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
YU67600A (sh) * | 1998-05-05 | 2003-07-07 | F.Hofmann - La Roche Ag. | Derivati pirazola kao inhibitori p-38 map kinaze |
US6376527B1 (en) | 1998-05-05 | 2002-04-23 | Syntex (U.S.A.) Llc | Pyrazole derivatives-p38 map kinase inhibitors |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
KR20010080402A (ko) | 1998-11-12 | 2001-08-22 | 추후기재 | Crf 수용체 길항제 및 그와 관련된 방법 |
ATE225349T1 (de) | 1998-11-12 | 2002-10-15 | Neurocrine Biosciences Inc | Crf rezeptor-antagonisten und darauf bezogene methoden |
FR2789387B1 (fr) * | 1999-02-04 | 2001-09-14 | Aventis Cropscience Sa | Nouveau procede de preparation d'intermediaires pesticides |
US6387894B1 (en) | 1999-06-11 | 2002-05-14 | Pfizer Inc. | Use of CRF antagonists and renin-angiotensin system inhibitors |
US6506784B1 (en) | 1999-07-01 | 2003-01-14 | 3-Dimensional Pharmaceuticals, Inc. | Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides |
US6409988B1 (en) | 1999-07-01 | 2002-06-25 | 3-Dimensional Pharmaceuticals, Inc. | Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands |
US6518266B1 (en) | 1999-07-22 | 2003-02-11 | 3-Dimensional Pharmaceuticals | 1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides |
WO2001025241A2 (en) | 1999-10-06 | 2001-04-12 | 3-Dimensional Pharmaceuticals, Inc. | Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides |
US6455525B1 (en) * | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
EP1293213A1 (en) * | 2000-02-14 | 2003-03-19 | Japan Tobacco Inc. | Preventives/remedies for postoperative stress |
US6531478B2 (en) * | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
US20060287335A1 (en) | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
US20060223824A1 (en) | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
GB0100621D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VI |
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
CZ301491B6 (cs) | 2001-04-27 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Pyrazolo[1,5-a]pyridiny a léciva s jejich obsahem |
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
US6638981B2 (en) | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
DE10142665B4 (de) | 2001-08-31 | 2004-05-06 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-one und ihre Derivate |
WO2003048160A1 (en) * | 2001-12-04 | 2003-06-12 | F. Hoffmann-La Roche Ag | Ring fused pyrazole derivatives |
US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
BRPI0313976B8 (pt) | 2002-10-22 | 2021-05-25 | Eisai Co Ltd | compostos de 7-fenilpirazolopiridina e uso dos mesmos na preparação de agente terapêutico ou profilático para doenças associadas com o crf ou seus receptores |
US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
DE60321958D1 (de) * | 2002-12-02 | 2008-08-14 | Hoffmann La Roche | Indazolderivate und ihre verwendung als crf antagonisten |
JP2006513257A (ja) | 2002-12-13 | 2006-04-20 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 線維筋痛症および他の障害を処置するためのプレガバリン誘導体 |
EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
WO2004092177A1 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
ATE418555T1 (de) | 2003-04-09 | 2009-01-15 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
NZ544230A (en) | 2003-06-26 | 2009-07-31 | Novartis Ag | 5-Membered heterocycle-based P38 kinase inhibitors |
KR101204247B1 (ko) | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도 |
US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
RU2006133265A (ru) * | 2004-02-18 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Гетероциклические модуляторы, селективные в отношении подтипа рецептора гамка |
WO2005115382A1 (en) * | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Crth2 receptor ligands for medicinal uses |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
MX2007012883A (es) * | 2005-04-22 | 2007-12-10 | Wyeth Corp | Derivados de dihidrobenzofurano y usos de los mismos. |
EP1871358A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists |
JP2008538577A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ジヒドロベンゾフラン誘導体およびその使用 |
EP1879875A1 (en) * | 2005-04-22 | 2008-01-23 | Wyeth | Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
WO2009104080A2 (en) | 2008-02-20 | 2009-08-27 | Targia Pharmaceuticals | Cns pharmaceutical compositions and methods of use |
PT2266990E (pt) | 2008-04-15 | 2012-12-27 | Eisai R&D Man Co Ltd | Composto de 3-fenilpirazolo[5,1-b]tiazole |
EP2291181B9 (en) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Captodiamine for the treatment of depression symptoms |
HUE028584T2 (en) | 2009-08-07 | 2016-12-28 | Chugai Pharmaceutical Co Ltd | Aminopyrazole derivatives |
AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
EP3581179A1 (en) | 2013-12-27 | 2019-12-18 | Chugai Seiyaku Kabushiki Kaisha | Fgfr gatekeeper mutant gene and drug targeting same |
EP3312172B1 (en) | 2015-06-17 | 2020-05-06 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives useful as src kinase inhibitors |
CA3022395A1 (en) | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
ES2932187T3 (es) | 2016-09-07 | 2023-01-16 | Fgh Biotech Inc | Compuestos de pirazol disustituidos para el tratamiento de enfermedades |
EP3563848A1 (en) * | 2018-04-30 | 2019-11-06 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Serpin inhibitors for the treatment of prion and prion-like diseases |
CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3778443A (en) * | 1969-02-13 | 1973-12-11 | Ciba Geigy Ag | 4-tetrahydro pyridyl,hydroxy alkyl pyrazoles |
FR2460299A1 (fr) * | 1979-07-05 | 1981-01-23 | Bellon Labor Sa Roger | Nouveaux derives du pyrazole et leur application therapeutique |
FR2472564A1 (fr) * | 1979-12-31 | 1981-07-03 | Bellon Labor Sa Roger | Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer |
DE3602728A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 51373 Leverkusen | Schaedlingsbekaempfungsmittel auf basis von pyrazolderivaten |
US5063245A (en) * | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
-
1993
- 1993-11-03 RU RU95113969/04A patent/RU2142946C1/ru not_active IP Right Cessation
- 1993-11-03 BR BR9307659A patent/BR9307659A/pt not_active Application Discontinuation
- 1993-11-03 PL PL93309356A patent/PL175831B1/pl unknown
- 1993-11-03 US US08/448,529 patent/US5712303A/en not_active Expired - Fee Related
- 1993-11-03 AT AT93925103T patent/ATE175961T1/de not_active IP Right Cessation
- 1993-11-03 KR KR1019950702478A patent/KR0170567B1/ko not_active IP Right Cessation
- 1993-11-03 WO PCT/US1993/010359 patent/WO1994013643A1/en active IP Right Grant
- 1993-11-03 DE DE69323212T patent/DE69323212T2/de not_active Expired - Fee Related
- 1993-11-03 AU AU54548/94A patent/AU690527B2/en not_active Ceased
- 1993-11-03 ES ES93925103T patent/ES2126661T3/es not_active Expired - Lifetime
- 1993-11-03 CA CA002150483A patent/CA2150483C/en not_active Expired - Fee Related
- 1993-11-03 DK DK93925103T patent/DK0674624T3/da active
- 1993-11-03 NZ NZ257770A patent/NZ257770A/en unknown
- 1993-11-03 JP JP6514147A patent/JP2862374B2/ja not_active Expired - Lifetime
- 1993-11-03 CZ CZ951585A patent/CZ284157B6/cs not_active IP Right Cessation
- 1993-11-03 EP EP93925103A patent/EP0674624B1/en not_active Expired - Lifetime
- 1993-11-06 TW TW082109298A patent/TW238303B/zh active
- 1993-12-09 IL IL10794693A patent/IL107946A/en not_active IP Right Cessation
- 1993-12-10 MY MYPI93002669A patent/MY131382A/en unknown
- 1993-12-15 EG EG79593A patent/EG20397A/xx active
- 1993-12-15 MX MX9308042A patent/MX9308042A/es unknown
- 1993-12-15 HU HU9303591A patent/HUT67457A/hu not_active Application Discontinuation
- 1993-12-15 ZA ZA939404A patent/ZA939404B/xx unknown
- 1993-12-16 FI FI935674A patent/FI113648B/fi not_active IP Right Cessation
- 1993-12-16 CN CN93120120A patent/CN1060768C/zh not_active Expired - Fee Related
-
1995
- 1995-06-16 NO NO952395A patent/NO304831B1/no unknown
-
1998
- 1998-06-29 MX MXPA98005325A patent/MXPA98005325A/es unknown
- 1998-11-25 NO NO985494A patent/NO306111B1/no unknown
-
1999
- 1999-03-04 GR GR990400652T patent/GR3029568T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO304831B1 (no) | Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet | |
FI935673A0 (fi) | Aminosubstituerade pyrazoler | |
FI935585A0 (fi) | Pyrrolopyrimidiner | |
KR960701051A (ko) | 이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases) | |
FI952900A (fi) | Polypeptidi ja siitä valmistettu anti-HIV-aine |