ES8604562A1 - Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina - Google Patents
Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolinaInfo
- Publication number
- ES8604562A1 ES8604562A1 ES545936A ES545936A ES8604562A1 ES 8604562 A1 ES8604562 A1 ES 8604562A1 ES 545936 A ES545936 A ES 545936A ES 545936 A ES545936 A ES 545936A ES 8604562 A1 ES8604562 A1 ES 8604562A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazoline
- substd
- opt
- pyridyl
- isoquinoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001879 copper Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE QUINAZOLINA E ISOQUINOLINA, DE FORMULA GENERAL (I), EN LA QUE X REPRESENTA NITROGENO O UN GRUPO -CH-; R1 Y R2 REPRESENTAN HIDROGENO, ALQUILO O ALCOXI; R3 REPRESENTA UN GRUPO 2-PIRIDILO SUSTITUIDO ONO SUSTITUIDO; Y R4 REPRESENTA HIDROGENO, UN GRUPO ALQUILO, ALCOXI O FENILO, Y SUS SALES DE ADICION DE ACIDO Y SUS COMPLEJOS DE COBRE. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1, R2, R3 Y X TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON UN NITRILO DE FORMULA GENERAL (III), EN LA QUE R4 TIENE EL SIGNIFICADO INDICADO. DE APLICACION EN TERAPEUTICA POR SU ACCION BIOCIDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8303328 | 1983-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES545936A0 ES545936A0 (es) | 1986-02-01 |
ES8604562A1 true ES8604562A1 (es) | 1986-02-01 |
Family
ID=19842465
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536402A Granted ES536402A0 (es) | 1983-09-29 | 1984-09-28 | Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina. |
ES545936A Expired ES8604562A1 (es) | 1983-09-29 | 1985-08-06 | Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536402A Granted ES536402A0 (es) | 1983-09-29 | 1984-09-28 | Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4694000A (es) |
EP (1) | EP0135975B1 (es) |
JP (1) | JPS61500019A (es) |
AT (1) | ATE37183T1 (es) |
AU (1) | AU572585B2 (es) |
CA (1) | CA1255674A (es) |
DE (1) | DE3474022D1 (es) |
ES (2) | ES536402A0 (es) |
NZ (1) | NZ209710A (es) |
WO (1) | WO1985001501A1 (es) |
ZA (1) | ZA847673B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
DE3675197D1 (de) * | 1985-12-03 | 1990-11-29 | Sumitomo Chemical Co | Pyridinylpyrimidin-derivate, verfahren zu deren herstellung und diese als wirksamen stoff enthaltende pflanzenkrankheiten-schutzmittel. |
IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4−アミノキナゾリン誘導体およびそれを含有する医薬品 |
US5583211A (en) * | 1992-10-29 | 1996-12-10 | Beckman Instruments, Inc. | Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides |
US5939431A (en) * | 1996-06-20 | 1999-08-17 | Schering Corporation | Naphthyridines which affect IL-4 and G-CSF |
US5929085A (en) * | 1996-11-06 | 1999-07-27 | Astra Aktiebolag | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase |
US6124374A (en) * | 1998-05-29 | 2000-09-26 | Block Drug Company, Inc. | Antimicrobial denture adhesive and cleanser compositions |
ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
CA2555867A1 (en) * | 2004-03-04 | 2005-09-22 | Neurogen Corporation | Arylalkylamino-substituted quinazoline analogues |
JP2009519995A (ja) * | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 呼吸器疾患の治療のためのカリウムチャンネル調節剤としての2−ピリジン−2−イル−キナゾリン誘導体 |
NL1035408C2 (nl) * | 2008-05-13 | 2009-11-16 | Dafra Pharma N V | Tuberculose prodrug derivaten. |
KR20130025860A (ko) | 2009-11-07 | 2013-03-12 | 메르크 파텐트 게엠베하 | Tgf-베타 수용체 키나아제 저해제로서의 헤테로아릴아미노퀴놀린 |
CN105175347B (zh) * | 2015-09-25 | 2018-01-23 | 温州医科大学附属第二医院 | 一种含氮杂环药物中间体的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3674791A (en) * | 1968-03-26 | 1972-07-04 | Marion Laboratories Inc | Benzamido 2 lower alkyl decahydroisoquinolines |
GB1390014A (en) * | 1971-05-07 | 1975-04-09 | Koninklijke Pharma Fab Nv | Process for the preparation of carbocyclic fused pyrimidine derivatives |
BE788608A (fr) * | 1971-09-09 | 1973-03-08 | Koninklijke Pharma Fab Nv | Aminoisoquinoleines |
US4125724A (en) * | 1975-12-29 | 1978-11-14 | Bristol-Myers Company | Hydrogenation process |
DE2826526A1 (de) * | 1977-06-17 | 1979-01-04 | Gist Brocades Nv | Kupferkomplexe von phenanthrolin-, isochinolin- und chinazolinderivaten, verfahren zu ihrer herstellung und ihre verwendung bei der bekaempfung von mykoplasmainfektionen |
US4171581A (en) * | 1977-11-14 | 1979-10-23 | Deepsea Ventures, Inc. | Water flow-deflecting shield for dredge suction nozzle |
DE2818403A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
-
1984
- 1984-09-28 US US06/679,000 patent/US4694000A/en not_active Expired - Fee Related
- 1984-09-28 AU AU35518/84A patent/AU572585B2/en not_active Ceased
- 1984-09-28 JP JP59503906A patent/JPS61500019A/ja active Pending
- 1984-09-28 CA CA000464249A patent/CA1255674A/en not_active Expired
- 1984-09-28 NZ NZ209710A patent/NZ209710A/en unknown
- 1984-09-28 DE DE8484201386T patent/DE3474022D1/de not_active Expired
- 1984-09-28 ZA ZA847673A patent/ZA847673B/xx unknown
- 1984-09-28 WO PCT/EP1984/000312 patent/WO1985001501A1/en unknown
- 1984-09-28 ES ES536402A patent/ES536402A0/es active Granted
- 1984-09-28 AT AT84201386T patent/ATE37183T1/de not_active IP Right Cessation
- 1984-09-28 EP EP84201386A patent/EP0135975B1/en not_active Expired
-
1985
- 1985-08-06 ES ES545936A patent/ES8604562A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0135975A3 (en) | 1985-06-12 |
ES8603459A1 (es) | 1985-12-16 |
EP0135975B1 (en) | 1988-09-14 |
ZA847673B (en) | 1985-05-29 |
CA1255674A (en) | 1989-06-13 |
NZ209710A (en) | 1988-02-12 |
ES545936A0 (es) | 1986-02-01 |
AU572585B2 (en) | 1988-05-12 |
WO1985001501A1 (en) | 1985-04-11 |
ES536402A0 (es) | 1985-12-16 |
ATE37183T1 (de) | 1988-09-15 |
JPS61500019A (ja) | 1986-01-09 |
US4694000A (en) | 1987-09-15 |
EP0135975A2 (en) | 1985-04-03 |
DE3474022D1 (de) | 1988-10-20 |
AU3551884A (en) | 1985-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960401 |