IL118379A - (2-morpholinylmethyl)benzamide derivatives their preparation and pharmaceutical compositions containing them - Google Patents
(2-morpholinylmethyl)benzamide derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL118379A IL118379A IL11837996A IL11837996A IL118379A IL 118379 A IL118379 A IL 118379A IL 11837996 A IL11837996 A IL 11837996A IL 11837996 A IL11837996 A IL 11837996A IL 118379 A IL118379 A IL 118379A
- Authority
- IL
- Israel
- Prior art keywords
- 6alkyl
- hydrogen
- alk
- amino
- 6alkyloxy
- Prior art date
Links
- QKWAMNZOEPKQBV-UHFFFAOYSA-N 2-(morpholin-2-ylmethyl)benzamide Chemical class NC(=O)C1=CC=CC=C1CC1OCCNC1 QKWAMNZOEPKQBV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- -1 C1-6alkyloxy Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000030136 gastric emptying Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201350 | 1995-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL118379A0 IL118379A0 (en) | 1996-09-12 |
| IL118379A true IL118379A (en) | 1999-12-31 |
Family
ID=8220318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11837996A IL118379A (en) | 1995-05-23 | 1996-05-22 | (2-morpholinylmethyl)benzamide derivatives their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6100262A (xx) |
| EP (1) | EP0827500B1 (xx) |
| JP (1) | JPH11505815A (xx) |
| KR (1) | KR100446099B1 (xx) |
| AT (1) | ATE208766T1 (xx) |
| AU (1) | AU710037B2 (xx) |
| CA (1) | CA2220140C (xx) |
| DE (1) | DE69617001T2 (xx) |
| DK (1) | DK0827500T3 (xx) |
| ES (1) | ES2167563T3 (xx) |
| IL (1) | IL118379A (xx) |
| MY (1) | MY117938A (xx) |
| NO (1) | NO309900B1 (xx) |
| NZ (1) | NZ309065A (xx) |
| PT (1) | PT827500E (xx) |
| TW (1) | TW505639B (xx) |
| WO (1) | WO1996037486A1 (xx) |
| ZA (1) | ZA964100B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0114323A (pt) * | 2000-09-29 | 2003-07-01 | Glaxo Group Ltd | Composto ou um seu sal ou solvato farmaceuticamente aceitável, composição farmacêutica, uso do composto ou de um seu sal ou solvato farmaceuticamente aceitável, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar o composto |
| UA77515C2 (en) * | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| HRP20220331T1 (hr) | 2018-03-08 | 2022-05-13 | Incyte Corporation | Spojevi aminopirazin diola kao inhibitori pi3k-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN110938068B (zh) * | 2019-11-06 | 2022-12-23 | 广东东阳光药业有限公司 | N-(吗啉-2-基甲基)酰胺衍生物及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ284687B6 (cs) * | 1986-04-30 | 1999-02-17 | Dainippon Pharmaceutical Co., Ltd. | Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi |
| CA2186623A1 (en) * | 1994-03-30 | 1995-10-21 | Takeshi Kawakita | Benzoic acid compound and use thereof as medicine |
-
1996
- 1996-05-15 DK DK96916121T patent/DK0827500T3/da active
- 1996-05-15 NZ NZ309065A patent/NZ309065A/xx unknown
- 1996-05-15 JP JP8535361A patent/JPH11505815A/ja active Pending
- 1996-05-15 PT PT96916121T patent/PT827500E/pt unknown
- 1996-05-15 KR KR1019970707669A patent/KR100446099B1/ko not_active IP Right Cessation
- 1996-05-15 AU AU58992/96A patent/AU710037B2/en not_active Ceased
- 1996-05-15 DE DE69617001T patent/DE69617001T2/de not_active Expired - Lifetime
- 1996-05-15 WO PCT/EP1996/002141 patent/WO1996037486A1/en active IP Right Grant
- 1996-05-15 CA CA002220140A patent/CA2220140C/en not_active Expired - Lifetime
- 1996-05-15 AT AT96916121T patent/ATE208766T1/de not_active IP Right Cessation
- 1996-05-15 EP EP96916121A patent/EP0827500B1/en not_active Expired - Lifetime
- 1996-05-15 ES ES96916121T patent/ES2167563T3/es not_active Expired - Lifetime
- 1996-05-21 MY MYPI96001904A patent/MY117938A/en unknown
- 1996-05-22 IL IL11837996A patent/IL118379A/xx not_active IP Right Cessation
- 1996-05-22 ZA ZA9604100A patent/ZA964100B/xx unknown
- 1996-06-04 TW TW085106627A patent/TW505639B/zh active
-
1997
- 1997-11-21 NO NO975342A patent/NO309900B1/no unknown
-
1999
- 1999-09-22 US US09/401,729 patent/US6100262A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO975342D0 (no) | 1997-11-21 |
| TW505639B (en) | 2002-10-11 |
| IL118379A0 (en) | 1996-09-12 |
| EP0827500A1 (en) | 1998-03-11 |
| ZA964100B (en) | 1997-11-24 |
| ES2167563T3 (es) | 2002-05-16 |
| CA2220140A1 (en) | 1996-11-28 |
| DK0827500T3 (da) | 2002-02-25 |
| DE69617001D1 (de) | 2001-12-20 |
| PT827500E (pt) | 2002-04-29 |
| ATE208766T1 (de) | 2001-11-15 |
| MY117938A (en) | 2004-08-30 |
| WO1996037486A1 (en) | 1996-11-28 |
| NZ309065A (en) | 1999-06-29 |
| NO975342L (no) | 1997-11-21 |
| AU5899296A (en) | 1996-12-11 |
| EP0827500B1 (en) | 2001-11-14 |
| NO309900B1 (no) | 2001-04-17 |
| US6100262A (en) | 2000-08-08 |
| JPH11505815A (ja) | 1999-05-25 |
| CA2220140C (en) | 2008-02-12 |
| KR19990008144A (ko) | 1999-01-25 |
| AU710037B2 (en) | 1999-09-09 |
| KR100446099B1 (ko) | 2004-11-10 |
| DE69617001T2 (de) | 2002-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |