MX9707511A - Derivados de diamino-1,3,5-triazina substituidos, su preparacion, composiciones que los contienen y el uso de los mismos. - Google Patents

Derivados de diamino-1,3,5-triazina substituidos, su preparacion, composiciones que los contienen y el uso de los mismos.

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Publication number
MX9707511A
MX9707511A MX9707511A MX9707511A MX9707511A MX 9707511 A MX9707511 A MX 9707511A MX 9707511 A MX9707511 A MX 9707511A MX 9707511 A MX9707511 A MX 9707511A MX 9707511 A MX9707511 A MX 9707511A
Authority
MX
Mexico
Prior art keywords
6alkyl
hydrogen
formula
nitro
products
Prior art date
Application number
MX9707511A
Other languages
English (en)
Other versions
MXPA97007511A (es
Inventor
Michael Joseph Kukla
Donald W Ludovici
Paul Adriaan Jan Janssen
Jan Heeres
Henri Emiel Lodewijk Moereels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX9707511A publication Critical patent/MX9707511A/es
Publication of MXPA97007511A publication Critical patent/MXPA97007511A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Esta invencion se refiere a compuestos de la formula (I): las sales ácidas de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas del mismo, en donde R1 y R2 se seleccionan cada uno independientemente de hidrogeno; hidroxi; amino; alquilo de C1-6 substituido opcionalmente; alquiloxi de C1-6; alquilcarbonilo de C1-6; alquiloxicarbonilo de C1-6; Ar1; mono- o dialquilamino de C1-6; mono- o dialquilaminocarbonilo de C1-6; dihidro-2(3H)-furanona: o R1 y R2 tomados juntos pueden formar pirrolidinilo, piperidinilo, morfolinilo, azido o mono- o dialquilamino de C1-6-alquilideno de C1-4; R3 es hidrogeno, Ar1, alquilcarbonilo de C1-6, alquilo de C1-6, alquiloxicarbonilo de C1-6, alquilo de C1-6 substituido con alquiloxicarbonilo de C1-6; y R4, R5, R6, R7 y R8 se seleccionan cada uno independientemente de hidrogeno, halo, alquilo, de C1-6, alquiloxi de C1-6, ciano, aminocarbonilo, nitro, amino, trihalometilo o trihalometiloxi; L es alquilo de C1-10 substituido opcionalmente; alquenilo de C3-10; alquinilo de C3-10; cicloalquilo de C3-7; Ar1 es fenilo substituido opcionalmente; en la fabricacion de una medicina pero el tratamiento de la infeccion con VIH (Virus de Inmunodeficiencia Humana) en sujetos que sufren de la misma, y se refiere además a compuestos nuevos que son un subgrupo de los compuestos de la formula (I), a su preparacion, composiciones que los comprenden y al uso de todos los compuestos mencionados.
MXPA/A/1997/007511A 1996-10-01 1997-09-30 Derivados de diamino-1,3,5-triazina substituidos, su preparacion, composiciones que los contienen y el uso de los mismos MXPA97007511A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2726096P 1996-10-01 1996-10-01
US60/027,260 1996-10-01

Publications (2)

Publication Number Publication Date
MX9707511A true MX9707511A (es) 1998-06-30
MXPA97007511A MXPA97007511A (es) 1998-10-30

Family

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Also Published As

Publication number Publication date
HU9701596D0 (en) 1997-11-28
HUP9701596A3 (en) 2000-04-28
NO311614B1 (no) 2001-12-17
RU2186774C2 (ru) 2002-08-10
AR008864A1 (es) 2000-02-23
CZ299397A3 (cs) 1998-11-11
DE69729153D1 (de) 2004-06-24
US6380194B1 (en) 2002-04-30
AU740809B2 (en) 2001-11-15
TR199701070A2 (xx) 1998-04-21
IL121849A0 (en) 1998-02-22
EE9700253A (et) 1998-04-15
CA2216486A1 (en) 1998-04-01
NZ328854A (en) 2000-10-27
US6962916B2 (en) 2005-11-08
SK131997A3 (en) 1999-06-11
ES2221679T3 (es) 2005-01-01
KR19980032428A (ko) 1998-07-25
IL121849A (en) 2001-08-26
NO974368L (no) 1998-04-02
MY123803A (en) 2006-06-30
HRP970526A2 (en) 1998-10-31
US20020147181A1 (en) 2002-10-10
HK1009676A1 (en) 1999-06-04
SG53075A1 (en) 1998-09-28
HRP970526B1 (en) 2002-10-31
AU3926697A (en) 1998-04-09
US20060189614A1 (en) 2006-08-24
EP0834507A1 (en) 1998-04-08
AP914A (en) 2000-12-18
HU225270B1 (en) 2006-08-28
EE03826B1 (et) 2002-08-15
EP0834507B1 (en) 2004-05-19
OA10620A (en) 2002-09-03
CZ297333B6 (cs) 2006-11-15
CN1180698A (zh) 1998-05-06
US7449575B2 (en) 2008-11-11
SI0834507T1 (en) 2004-10-31
ATE267179T1 (de) 2004-06-15
US6858609B2 (en) 2005-02-22
AP9701109A0 (en) 1997-10-31
SK285241B6 (sk) 2006-09-07
TW411335B (en) 2000-11-11
ZA978766B (en) 1999-03-30
JPH10114759A (ja) 1998-05-06
CN1083438C (zh) 2002-04-24
KR100478846B1 (ko) 2006-06-13
PT834507E (pt) 2004-10-29
HUP9701596A2 (hu) 1999-06-28
BR9704937A (pt) 2000-06-06
US20030199473A1 (en) 2003-10-23
PL322369A1 (en) 1998-04-14
NO974368D0 (no) 1997-09-22
ID19599A (id) 1998-07-23
DE69729153T2 (de) 2005-01-27
DK0834507T3 (da) 2004-09-06
PL190155B1 (pl) 2005-11-30
JP4127882B2 (ja) 2008-07-30

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