MX9702356A - Derivados de fenil-oxo-alquil-(4-piperidinil)benzoato. - Google Patents

Derivados de fenil-oxo-alquil-(4-piperidinil)benzoato.

Info

Publication number
MX9702356A
MX9702356A MX9702356A MX9702356A MX9702356A MX 9702356 A MX9702356 A MX 9702356A MX 9702356 A MX9702356 A MX 9702356A MX 9702356 A MX9702356 A MX 9702356A MX 9702356 A MX9702356 A MX 9702356A
Authority
MX
Mexico
Prior art keywords
hydrogen
6alkyl
formula
benzoate derivatives
6alkyloxy
Prior art date
Application number
MX9702356A
Other languages
English (en)
Other versions
MXPA97002356A (es
Inventor
Daele Georges Henri Paul Van
Jean-Paul Rene Marie A Bosmans
Marc Gustaaf Celine Verdonck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP1995/003690 external-priority patent/WO1996010026A1/en
Publication of MX9702356A publication Critical patent/MX9702356A/es
Publication of MXPA97002356A publication Critical patent/MXPA97002356A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invencion se refiere a derivados de benzoato novedosos que tienen la formula (I), las formas de N-oxido, las sales ácidas de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de los mismos, en donde R1 es halo o alquilosulfonilamino de C1-6; R2 es hidrogeno y R3 es alquilo de C1-6, alquenilo de C2-6 o alquinilo de C2-6; o R2 y R3 tomados juntos forman un radical bivalente de la formula -CH=CH- (a), -(CH2)2- (b) o -(CH2)3- (c); en los radicales bivalentes de la formula (a), (b) o (c) uno o más dos átomos de hidrogeno puede ser reemplazado por alquilo de C1-6; Alk es alcanediilo de C1-6; R4 es hidrogeno o alquiloxi de C1-6; R5, R6 y R7 cada uno independientemente es hidrogeno, halo, alquilo de C1-6, alquiloxi de C1-6; o R5 y R6 tomados juntos también pueden formar un radical bivalente de la formula: -NR8C(O)NR9-, -NH-C(NHR10)=N-, -O-(CH2)m-O-; R8 y R9 cada uno independientemente es hidrogeno o alquilo de C1-6; R10 es hidrogeno, alquilcarbonilo de C1-6, alquiloxicarbonilo de C1-6; m es 1 o 2; se describen las composiciones farmacéuticas que comprenden dichos compuestos, procedimientos para preparar los compuestos y composiciones así como el uso de una medicina, en particular para el tratamiento de perturbaciones intestinales que involucran una movilidad disminuida del colon.
MXPA/A/1997/002356A 1994-09-27 1995-09-19 Derivados de fenil-oxo-alquil-(4-piperidinil)benzoato MXPA97002356A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US454776 1989-12-19
EP94202791 1994-09-27
EP94202791.3 1994-09-27
US45477695A 1995-05-31 1995-05-31
PCT/EP1995/003690 WO1996010026A1 (en) 1994-09-27 1995-09-19 Phenyl-oxo-alkyl-(4-piperidinyl)benzoate derivatives

Publications (2)

Publication Number Publication Date
MX9702356A true MX9702356A (es) 1997-10-31
MXPA97002356A MXPA97002356A (es) 1998-07-03

Family

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Also Published As

Publication number Publication date
IL115412A (en) 2000-02-17
NO311673B1 (no) 2002-01-02
CZ91997A3 (en) 1997-12-17
NO971375L (no) 1997-05-05
NO971375D0 (no) 1997-03-24
HUT77311A (hu) 1998-03-30
MY117105A (en) 2004-05-31
PL182174B1 (pl) 2001-11-30
PL319998A1 (en) 1997-09-01
CZ288942B6 (cs) 2001-10-17
IL115412A0 (en) 1995-12-31
NZ293604A (en) 1998-07-28

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