IT1402842B1 - 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine. - Google Patents
7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine.Info
- Publication number
- IT1402842B1 IT1402842B1 ITFI2010A000233A ITFI20100233A IT1402842B1 IT 1402842 B1 IT1402842 B1 IT 1402842B1 IT FI2010A000233 A ITFI2010A000233 A IT FI2010A000233A IT FI20100233 A ITFI20100233 A IT FI20100233A IT 1402842 B1 IT1402842 B1 IT 1402842B1
- Authority
- IT
- Italy
- Prior art keywords
- ilmethyl
- diazepin
- pyrrolidin
- benzo
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITFI2010A000233A IT1402842B1 (it) | 2010-11-30 | 2010-11-30 | 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine. |
| PCT/EP2011/071252 WO2012072620A1 (en) | 2010-11-30 | 2011-11-29 | 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1h-benzo[e][1,4]diazepin-2(3h)-one and other benzodiazepine derivatives |
| EP11801632.8A EP2646421B1 (en) | 2010-11-30 | 2011-11-29 | 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1h-benzo[e][1,4]diazepin-2(3h)-one and other benzodiazepine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITFI2010A000233A IT1402842B1 (it) | 2010-11-30 | 2010-11-30 | 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITFI20100233A1 ITFI20100233A1 (it) | 2012-05-31 |
| IT1402842B1 true IT1402842B1 (it) | 2013-09-27 |
Family
ID=43742622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITFI2010A000233A IT1402842B1 (it) | 2010-11-30 | 2010-11-30 | 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2646421B1 (it) |
| IT (1) | IT1402842B1 (it) |
| WO (1) | WO2012072620A1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108586447B (zh) * | 2018-01-19 | 2021-01-29 | 中国人民解放军第四军医大学 | 一种苯二氮杂卓化合物及其制备方法和应用 |
| ES2910071T3 (es) | 2018-03-08 | 2022-05-11 | Incyte Corp | Compuestos de aminopirazina diol como inhibidores de PI3K-Y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003106628A2 (en) * | 2002-06-17 | 2003-12-24 | Bristol-Myers Squibb Company | Benzodiazepine inhibitors of mitochondial f1f0 atp hydrolase and methods of inhibiting f1f0 atp hydrolase |
-
2010
- 2010-11-30 IT ITFI2010A000233A patent/IT1402842B1/it active
-
2011
- 2011-11-29 EP EP11801632.8A patent/EP2646421B1/en active Active
- 2011-11-29 WO PCT/EP2011/071252 patent/WO2012072620A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2646421A1 (en) | 2013-10-09 |
| EP2646421B1 (en) | 2015-05-06 |
| ITFI20100233A1 (it) | 2012-05-31 |
| WO2012072620A1 (en) | 2012-06-07 |
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