SMT201400157B - Derivati di 2-piridin-2-il-pirazol-3(2H)-one, loropreparazione e loro uso terapeutico - Google Patents
Derivati di 2-piridin-2-il-pirazol-3(2H)-one, loropreparazione e loro uso terapeuticoInfo
- Publication number
- SMT201400157B SMT201400157B SM201400157T SM201400157T SMT201400157B SM T201400157 B SMT201400157 B SM T201400157B SM 201400157 T SM201400157 T SM 201400157T SM 201400157 T SM201400157 T SM 201400157T SM T201400157 B SMT201400157 B SM T201400157B
- Authority
- SM
- San Marino
- Prior art keywords
- pyrazol
- pyridin
- derivatives
- preparation
- therapeutic use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0807475A FR2940652B1 (fr) | 2008-12-29 | 2008-12-29 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique |
| FR0904091A FR2949468B1 (fr) | 2009-08-28 | 2009-08-28 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique |
| PCT/FR2009/052692 WO2010076525A1 (fr) | 2008-12-29 | 2009-12-24 | Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400157B true SMT201400157B (it) | 2015-01-15 |
Family
ID=41728182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400157T SMT201400157B (it) | 2008-12-29 | 2014-10-29 | Derivati di 2-piridin-2-il-pirazol-3(2H)-one, loropreparazione e loro uso terapeutico |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US8697731B2 (it) |
| EP (1) | EP2382215B1 (it) |
| JP (1) | JP5865704B2 (it) |
| KR (1) | KR101630475B1 (it) |
| CN (1) | CN102333776B (it) |
| AR (1) | AR074916A1 (it) |
| AU (1) | AU2009334570B2 (it) |
| BR (1) | BRPI0923875A2 (it) |
| CA (1) | CA2748413A1 (it) |
| CO (1) | CO6400145A2 (it) |
| CR (1) | CR20110360A (it) |
| CY (1) | CY1115635T1 (it) |
| DK (1) | DK2382215T3 (it) |
| EA (1) | EA019774B1 (it) |
| EC (1) | ECSP11011164A (it) |
| ES (1) | ES2511917T3 (it) |
| HK (1) | HK1163679A1 (it) |
| IL (1) | IL213790A (it) |
| MA (1) | MA32978B1 (it) |
| MX (1) | MX2011007061A (it) |
| MY (1) | MY155244A (it) |
| NI (1) | NI201100132A (it) |
| NZ (1) | NZ593797A (it) |
| PA (1) | PA8856101A1 (it) |
| PE (1) | PE20120338A1 (it) |
| PL (1) | PL2382215T3 (it) |
| PT (1) | PT2382215E (it) |
| SG (1) | SG172422A1 (it) |
| SI (1) | SI2382215T1 (it) |
| SM (1) | SMT201400157B (it) |
| TN (1) | TN2011000308A1 (it) |
| TW (1) | TWI441828B (it) |
| WO (1) | WO2010076525A1 (it) |
| ZA (1) | ZA201104785B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2382215T1 (sl) | 2008-12-29 | 2020-06-30 | Sanofi | Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba |
| EP2361911A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| EP2361912A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| ES2699404T3 (es) * | 2012-03-30 | 2019-02-11 | Daiichi Sankyo Co Ltd | Derivado de 4-alcanoilamino-3-pirazolona |
| CN102731384B (zh) * | 2012-07-10 | 2016-04-06 | 南开大学 | 一种6-甲基烟酸叔丁酯的合成方法 |
| KR102376354B1 (ko) * | 2013-03-29 | 2022-04-04 | 다케다 야쿠힌 고교 가부시키가이샤 | 6-(5-히드록시-1h-피라졸-1-일)니코틴아미드 유도체 및 ｐｈｄ의 저해제로서의 그의 용도 |
| CN105061316B (zh) * | 2015-07-17 | 2017-12-22 | 苏州大学 | 稠环类化合物、制备方法和用途 |
| CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3917469A1 (de) * | 1989-05-30 | 1990-12-06 | Bayer Ag | Heterocyclylpyridine |
| DE4023488A1 (de) | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
| US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
| GB9704762D0 (en) | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
| EP1646382A4 (en) * | 2003-06-30 | 2010-07-21 | Hif Bio Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| CN1842332A (zh) * | 2003-06-30 | 2006-10-04 | Hif生物公司 | 化合物、组合物及方法 |
| DE102005019712A1 (de) | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
| PE20071020A1 (es) * | 2006-03-07 | 2007-12-11 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa |
| JP5443988B2 (ja) * | 2006-10-16 | 2014-03-19 | メディシス・ファーマシューティカル・コーポレーション | 治療用のピラゾリルチエノピリジン |
| DE102006050516A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
| CA2687306A1 (en) * | 2007-05-18 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
| CA2748411A1 (fr) | 2008-12-29 | 2010-07-08 | Sanofi | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
| SI2382215T1 (sl) | 2008-12-29 | 2020-06-30 | Sanofi | Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba |
-
2009
- 2009-12-24 SI SI200931025T patent/SI2382215T1/sl unknown
- 2009-12-24 CN CN200980157589.3A patent/CN102333776B/zh not_active Expired - Fee Related
- 2009-12-24 KR KR1020117017677A patent/KR101630475B1/ko active IP Right Grant
- 2009-12-24 BR BRPI0923875-1A patent/BRPI0923875A2/pt not_active IP Right Cessation
- 2009-12-24 PL PL09805790T patent/PL2382215T3/pl unknown
- 2009-12-24 CA CA2748413A patent/CA2748413A1/fr not_active Abandoned
- 2009-12-24 WO PCT/FR2009/052692 patent/WO2010076525A1/fr active Application Filing
- 2009-12-24 NZ NZ593797A patent/NZ593797A/xx not_active IP Right Cessation
- 2009-12-24 DK DK09805790.4T patent/DK2382215T3/da active
- 2009-12-24 ES ES09805790.4T patent/ES2511917T3/es active Active
- 2009-12-24 MY MYPI2011003011A patent/MY155244A/en unknown
- 2009-12-24 EP EP09805790.4A patent/EP2382215B1/fr active Active
- 2009-12-24 EA EA201170900A patent/EA019774B1/ru not_active IP Right Cessation
- 2009-12-24 PE PE2011001291A patent/PE20120338A1/es not_active Application Discontinuation
- 2009-12-24 AU AU2009334570A patent/AU2009334570B2/en not_active Ceased
- 2009-12-24 MX MX2011007061A patent/MX2011007061A/es active IP Right Grant
- 2009-12-24 PT PT98057904T patent/PT2382215E/pt unknown
- 2009-12-24 SG SG2011047529A patent/SG172422A1/en unknown
- 2009-12-24 MA MA34029A patent/MA32978B1/fr unknown
- 2009-12-24 JP JP2011542887A patent/JP5865704B2/ja not_active Expired - Fee Related
- 2009-12-28 TW TW098145333A patent/TWI441828B/zh not_active IP Right Cessation
- 2009-12-28 PA PA20098856101A patent/PA8856101A1/es unknown
- 2009-12-28 AR ARP090105127A patent/AR074916A1/es unknown
-
2011
- 2011-06-17 TN TN2011000308A patent/TN2011000308A1/fr unknown
- 2011-06-23 CR CR20110360A patent/CR20110360A/es unknown
- 2011-06-27 IL IL213790A patent/IL213790A/en not_active IP Right Cessation
- 2011-06-27 EC EC2011011164A patent/ECSP11011164A/es unknown
- 2011-06-28 NI NI201100132A patent/NI201100132A/es unknown
- 2011-06-28 ZA ZA2011/04785A patent/ZA201104785B/en unknown
- 2011-06-29 CO CO11081313A patent/CO6400145A2/es active IP Right Grant
- 2011-06-29 US US13/172,321 patent/US8697731B2/en not_active Expired - Fee Related
-
2012
- 2012-05-02 HK HK12104300.3A patent/HK1163679A1/xx not_active IP Right Cessation
-
2014
- 2014-03-07 US US14/200,698 patent/US9359329B2/en not_active Expired - Fee Related
- 2014-10-16 CY CY20141100849T patent/CY1115635T1/el unknown
- 2014-10-29 SM SM201400157T patent/SMT201400157B/it unknown
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