AR074916A1 - Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparacion, composiciones farmaceuticas y su uso en enfermedades cardiovasculares. - Google Patents
Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparacion, composiciones farmaceuticas y su uso en enfermedades cardiovasculares.Info
- Publication number
- AR074916A1 AR074916A1 ARP090105127A ARP090105127A AR074916A1 AR 074916 A1 AR074916 A1 AR 074916A1 AR P090105127 A ARP090105127 A AR P090105127A AR P090105127 A ARP090105127 A AR P090105127A AR 074916 A1 AR074916 A1 AR 074916A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr5r6
- group
- groups
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La solicitud se refiere a los compuestos que responden a la fórmula (1), en estado de base o de sal por adición de un ácido, en la cual n es igual a 0, 1, 2, 3, o 4; m es igual a 0, 1 o 2; o es igual a 0 o 1; X es un grupo -CH2, -CH(R')-; -NH(R')- o un heteroátomo seleccionado entre O y S, entendiéndose que R' representa un grupo alquilo C1-5-alquilo, alcoxi C1-5, -CH2-arilo, -C(O)R5 o -COOR5; R1 representa un grupo oxo, -COOR5, -W-OH o -W-NR5R6; R2 representa un átomo de hidrógeno, o un grupo seleccionado entre los grupos -alquilo C1-5, alcoxi C1-5, -COOR5, -NR5R6, -C(O)-NR5R6, -SO2NR3R4, heteroarilo eventualmente sustituidos con un grupo alquilo C1-5, -W-arilo, -W-heteroarilo, -O-W-arilo; -O-W-heteroarilo y -O-W-NR5R6; entendiéndose que R3 y R4, que pueden ser idénticos o diferentes, representan, independientemente uno de otro, un átomo H, -alquilo C1-5, -cicloalquilo C3-6, arilo, heteroarilo, -CH2-heteroarilo, alquilo C1-5-NR5R6, -W-OH, o -W-NR5R6, o forman junto con el átomo de N que los porta un grupo heterocicloalquilo eventualmente sustituido con uno o varios grupos seleccionados entre los grupos alquilo C1-5 y -CH-arilo; W es un grupo alquileno C1-5; eventualmente sustituido con uno o varios grupos hidroxi; R5 y R6, que pueden ser idénticos o diferentes, representan, independientemente uno de otro, un átomo de H o un grupo seleccionado entre los grupos alquilo C1-5, y los grupos cicloalquilo C3-6, así como su procedimiento de preparación y sus aplicaciones en terapéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0807475A FR2940652B1 (fr) | 2008-12-29 | 2008-12-29 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique |
FR0904091A FR2949468B1 (fr) | 2009-08-28 | 2009-08-28 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074916A1 true AR074916A1 (es) | 2011-02-23 |
Family
ID=41728182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090105127A AR074916A1 (es) | 2008-12-29 | 2009-12-28 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparacion, composiciones farmaceuticas y su uso en enfermedades cardiovasculares. |
Country Status (34)
Country | Link |
---|---|
US (2) | US8697731B2 (es) |
EP (1) | EP2382215B1 (es) |
JP (1) | JP5865704B2 (es) |
KR (1) | KR101630475B1 (es) |
CN (1) | CN102333776B (es) |
AR (1) | AR074916A1 (es) |
AU (1) | AU2009334570B2 (es) |
BR (1) | BRPI0923875A2 (es) |
CA (1) | CA2748413A1 (es) |
CO (1) | CO6400145A2 (es) |
CR (1) | CR20110360A (es) |
CY (1) | CY1115635T1 (es) |
DK (1) | DK2382215T3 (es) |
EA (1) | EA019774B1 (es) |
EC (1) | ECSP11011164A (es) |
ES (1) | ES2511917T3 (es) |
HK (1) | HK1163679A1 (es) |
IL (1) | IL213790A (es) |
MA (1) | MA32978B1 (es) |
MX (1) | MX2011007061A (es) |
MY (1) | MY155244A (es) |
NI (1) | NI201100132A (es) |
NZ (1) | NZ593797A (es) |
PA (1) | PA8856101A1 (es) |
PE (1) | PE20120338A1 (es) |
PL (1) | PL2382215T3 (es) |
PT (1) | PT2382215E (es) |
SG (1) | SG172422A1 (es) |
SI (1) | SI2382215T1 (es) |
SM (1) | SMT201400157B (es) |
TN (1) | TN2011000308A1 (es) |
TW (1) | TWI441828B (es) |
WO (1) | WO2010076525A1 (es) |
ZA (1) | ZA201104785B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2511917T3 (es) | 2008-12-29 | 2014-10-23 | Sanofi | Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y su aplicación en terapéutica |
EP2361912A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
EP2361911A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
KR20140138208A (ko) * | 2012-03-30 | 2014-12-03 | 다이이찌 산쿄 가부시키가이샤 | 4-알카노일아미노-3-피라졸론 유도체 |
CN102731384B (zh) * | 2012-07-10 | 2016-04-06 | 南开大学 | 一种6-甲基烟酸叔丁酯的合成方法 |
PE20151860A1 (es) | 2013-03-29 | 2015-12-16 | Takeda Pharmaceutical | Derivados de 6-(5-hidroxi-1h-pirazol-1-il)nicotinamida y su uso como inhidores de la phd |
CN105061316B (zh) * | 2015-07-17 | 2017-12-22 | 苏州大学 | 稠环类化合物、制备方法和用途 |
CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3917469A1 (de) * | 1989-05-30 | 1990-12-06 | Bayer Ag | Heterocyclylpyridine |
DE4023488A1 (de) | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
GB9704762D0 (en) | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
CN1842332A (zh) * | 2003-06-30 | 2006-10-04 | Hif生物公司 | 化合物、组合物及方法 |
KR20060110741A (ko) * | 2003-06-30 | 2006-10-25 | 히프 바이오 인크 | 화합물, 조성물 및 방법 |
DE102005019712A1 (de) | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
TW200808793A (en) * | 2006-03-07 | 2008-02-16 | Smithkline Beecham Corp | Prolyl hydroxylase inhibitors |
CA2666603C (en) * | 2006-10-16 | 2013-08-06 | Pfizer Products Inc. | Therapeutic pyrazolyl thienopyridines and uses thereof for treating tgf.beta. mediated conditions |
DE102006050516A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
AU2008253311A1 (en) * | 2007-05-18 | 2008-11-27 | Bayer Schering Pharma Aktiengesellshaft | Inhibitors of hypoxia inducible factor (HIF) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
ES2511917T3 (es) | 2008-12-29 | 2014-10-23 | Sanofi | Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y su aplicación en terapéutica |
DK2382205T3 (da) | 2008-12-29 | 2014-07-28 | Sanofi Sa | 2-pyridin-2-yl-pyrazol-3(2h)-on-derivater, fremstilling deraf og terapeutisk anvendelse deraf som hif-aktivatorer |
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2009
- 2009-12-24 ES ES09805790.4T patent/ES2511917T3/es active Active
- 2009-12-24 KR KR1020117017677A patent/KR101630475B1/ko active IP Right Grant
- 2009-12-24 PL PL09805790T patent/PL2382215T3/pl unknown
- 2009-12-24 AU AU2009334570A patent/AU2009334570B2/en not_active Ceased
- 2009-12-24 CA CA2748413A patent/CA2748413A1/fr not_active Abandoned
- 2009-12-24 MY MYPI2011003011A patent/MY155244A/en unknown
- 2009-12-24 JP JP2011542887A patent/JP5865704B2/ja not_active Expired - Fee Related
- 2009-12-24 EA EA201170900A patent/EA019774B1/ru not_active IP Right Cessation
- 2009-12-24 PT PT98057904T patent/PT2382215E/pt unknown
- 2009-12-24 SG SG2011047529A patent/SG172422A1/en unknown
- 2009-12-24 NZ NZ593797A patent/NZ593797A/xx not_active IP Right Cessation
- 2009-12-24 MX MX2011007061A patent/MX2011007061A/es active IP Right Grant
- 2009-12-24 WO PCT/FR2009/052692 patent/WO2010076525A1/fr active Application Filing
- 2009-12-24 BR BRPI0923875-1A patent/BRPI0923875A2/pt not_active IP Right Cessation
- 2009-12-24 DK DK09805790.4T patent/DK2382215T3/da active
- 2009-12-24 CN CN200980157589.3A patent/CN102333776B/zh not_active Expired - Fee Related
- 2009-12-24 EP EP09805790.4A patent/EP2382215B1/fr active Active
- 2009-12-24 PE PE2011001291A patent/PE20120338A1/es not_active Application Discontinuation
- 2009-12-24 SI SI200931025T patent/SI2382215T1/sl unknown
- 2009-12-24 MA MA34029A patent/MA32978B1/fr unknown
- 2009-12-28 PA PA20098856101A patent/PA8856101A1/es unknown
- 2009-12-28 TW TW098145333A patent/TWI441828B/zh not_active IP Right Cessation
- 2009-12-28 AR ARP090105127A patent/AR074916A1/es unknown
-
2011
- 2011-06-17 TN TN2011000308A patent/TN2011000308A1/fr unknown
- 2011-06-23 CR CR20110360A patent/CR20110360A/es unknown
- 2011-06-27 EC EC2011011164A patent/ECSP11011164A/es unknown
- 2011-06-27 IL IL213790A patent/IL213790A/en not_active IP Right Cessation
- 2011-06-28 ZA ZA2011/04785A patent/ZA201104785B/en unknown
- 2011-06-28 NI NI201100132A patent/NI201100132A/es unknown
- 2011-06-29 US US13/172,321 patent/US8697731B2/en not_active Expired - Fee Related
- 2011-06-29 CO CO11081313A patent/CO6400145A2/es active IP Right Grant
-
2012
- 2012-05-02 HK HK12104300.3A patent/HK1163679A1/xx not_active IP Right Cessation
-
2014
- 2014-03-07 US US14/200,698 patent/US9359329B2/en not_active Expired - Fee Related
- 2014-10-16 CY CY20141100849T patent/CY1115635T1/el unknown
- 2014-10-29 SM SM201400157T patent/SMT201400157B/xx unknown
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