EA201591451A1 - Модуляторы flap - Google Patents
Модуляторы flapInfo
- Publication number
- EA201591451A1 EA201591451A1 EA201591451A EA201591451A EA201591451A1 EA 201591451 A1 EA201591451 A1 EA 201591451A1 EA 201591451 A EA201591451 A EA 201591451A EA 201591451 A EA201591451 A EA 201591451A EA 201591451 A1 EA201591451 A1 EA 201591451A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- flap modulators
- compounds
- formula
- modulators
- flap
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract
Изобретение относится к соединениям формулы (I)или их форме, в которых кольца A, RL и Rподходят, как определено в настоящем документе, для использования в качестве модуляторов FLAP. Изобретение также относится к фармацевтическим композициям, содержащим соединения формулы (I). Способы получения и использования соединений формулы (I) также входят в объем настоящего изобретения.
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US201361760615P | 2013-02-04 | 2013-02-04 | |
US201361798951P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/014088 WO2014121040A1 (en) | 2013-02-04 | 2014-01-31 | Flap modulators |
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EA201591451A1 true EA201591451A1 (ru) | 2015-12-30 |
EA030404B1 EA030404B1 (ru) | 2018-07-31 |
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US (4) | US9732093B2 (ru) |
EP (1) | EP2951169B1 (ru) |
JP (1) | JP6328145B2 (ru) |
KR (1) | KR20160004258A (ru) |
CN (1) | CN105073742B (ru) |
AU (2) | AU2014212193B2 (ru) |
BR (1) | BR112015018504A2 (ru) |
CA (1) | CA2899904A1 (ru) |
EA (1) | EA030404B1 (ru) |
HK (1) | HK1217489A1 (ru) |
MX (1) | MX364069B (ru) |
TW (1) | TWI644899B (ru) |
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TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
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US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
CA2903813C (en) | 2013-03-15 | 2023-08-29 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
WO2014144455A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
WO2016044641A2 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
CN104961642A (zh) * | 2015-06-26 | 2015-10-07 | 华中药业股份有限公司 | 一种合成普萘洛尔的新方法 |
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CN108329330B (zh) * | 2017-01-20 | 2021-05-04 | 复旦大学 | 2-苄氧苯基噁唑并吡啶类化合物及其药物用途 |
BR112021013924A2 (pt) | 2019-01-18 | 2021-09-21 | Astrazeneca Ab | Inibidores de pcsk9 e métodos de uso do mesmo |
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CN116848119A (zh) * | 2021-02-08 | 2023-10-03 | 杭州中美华东制药有限公司 | 一种吡咯并哒嗪类化合物及其制备方法和用途 |
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KR20160004258A (ko) | 2016-01-12 |
US20140221310A1 (en) | 2014-08-07 |
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TWI644899B (zh) | 2018-12-21 |
AU2014212193B2 (en) | 2017-06-15 |
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AU2017213500A1 (en) | 2017-08-31 |
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MX364069B (es) | 2019-04-10 |
TW201444799A (zh) | 2014-12-01 |
EP2951169B1 (en) | 2019-08-28 |
US20150252008A1 (en) | 2015-09-10 |
JP6328145B2 (ja) | 2018-05-23 |
BR112015018504A2 (pt) | 2017-07-18 |
AU2014212193A1 (en) | 2015-07-30 |
US10047101B2 (en) | 2018-08-14 |
AU2017213500B2 (en) | 2019-02-28 |
WO2014121040A1 (en) | 2014-08-07 |
WO2014121040A8 (en) | 2015-02-12 |
US20150368270A1 (en) | 2015-12-24 |
MX2015010106A (es) | 2016-01-14 |
JP2016514089A (ja) | 2016-05-19 |
UY35305A (es) | 2014-08-29 |
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