EA201591451A1 - Модуляторы flap - Google Patents

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Publication number
EA201591451A1
EA201591451A1 EA201591451A EA201591451A EA201591451A1 EA 201591451 A1 EA201591451 A1 EA 201591451A1 EA 201591451 A EA201591451 A EA 201591451A EA 201591451 A EA201591451 A EA 201591451A EA 201591451 A1 EA201591451 A1 EA 201591451A1
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EA
Eurasian Patent Office
Prior art keywords
flap modulators
compounds
formula
modulators
flap
Prior art date
Application number
EA201591451A
Other languages
English (en)
Other versions
EA030404B1 (ru
Inventor
Уэнди Экклс
Энн Е. Фитцджералд
Майкл Д. Хэк
Натали А. Гаврилюк
Уилльям М. Джоунс
Джон М. Кейт
Пол Кравчук
Алек Д. Лебсак
Цзин Лю
Неелакандха С. Мани
Келли Дж. Макклур
Стивен П. Медуна
Марк Д. Роузен
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201591451A1 publication Critical patent/EA201591451A1/ru
Publication of EA030404B1 publication Critical patent/EA030404B1/ru

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Изобретение относится к соединениям формулы (I)или их форме, в которых кольца A, RL и Rподходят, как определено в настоящем документе, для использования в качестве модуляторов FLAP. Изобретение также относится к фармацевтическим композициям, содержащим соединения формулы (I). Способы получения и использования соединений формулы (I) также входят в объем настоящего изобретения.
EA201591451A 2013-02-04 2014-01-31 Модуляторы flap EA030404B1 (ru)

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