MX9302824A - Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca - Google Patents

Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca

Info

Publication number
MX9302824A
MX9302824A MX9302824A MX9302824A MX9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A
Authority
MX
Mexico
Prior art keywords
piridazo
diazepina
piridazina
pirazolo
inhibitors
Prior art date
Application number
MX9302824A
Other languages
English (en)
Inventor
Gary A Flynn
Patrick W Shum
Original Assignee
Merrell Dow Pahmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pahmaceuticals Inc filed Critical Merrell Dow Pahmaceuticals Inc
Publication of MX9302824A publication Critical patent/MX9302824A/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La encefalinasa o más específicamente, la endopeptidasa 24.11 es una ectoenzima de mamífero, la cual está implicada en la degradación metabólica de ciertos péptidos reguladores en circulación. Esta enzima, la cual es una Zn+2-metalopeptidasa, ejerce su efecto desdoblado a los péptidos extracelulares en al grupo amino de los residuos hidrofóbicos e inactiva en esta forma a los péptidos como mensajeros reguladores. La encefalinasa está implicada en la degradación metabólica de una variedad de péptidos reguladores circulantes, incluyendo las endorfinas, tales como (beta)-endorfina y las encefalinas, el péptido natriurético atrial (ANP) y otros péptidos reguladores circulantes.
MX9302824A 1992-05-15 1993-05-14 Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca MX9302824A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US4000393A 1993-04-09 1993-04-09

Publications (1)

Publication Number Publication Date
MX9302824A true MX9302824A (es) 1994-05-31

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302824A MX9302824A (es) 1992-05-15 1993-05-14 Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca

Country Status (19)

Country Link
US (1) US5366973A (es)
EP (1) EP0640086B1 (es)
JP (1) JP3360079B2 (es)
KR (1) KR100281450B1 (es)
AT (1) ATE182892T1 (es)
AU (1) AU669364B2 (es)
CA (1) CA2133963C (es)
DE (1) DE69325904T2 (es)
DK (1) DK0640086T3 (es)
ES (1) ES2138622T3 (es)
FI (1) FI108230B (es)
GR (1) GR3031287T3 (es)
HU (1) HU223663B1 (es)
IL (1) IL105680A (es)
MX (1) MX9302824A (es)
NO (1) NO302573B1 (es)
NZ (1) NZ251930A (es)
TW (1) TW270115B (es)
WO (1) WO1993023403A1 (es)

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Also Published As

Publication number Publication date
EP0640086A1 (en) 1995-03-01
GR3031287T3 (en) 1999-12-31
AU4033293A (en) 1993-12-13
NO944335D0 (no) 1994-11-14
DE69325904T2 (de) 1999-12-09
NZ251930A (en) 1996-02-27
TW270115B (es) 1996-02-11
JPH07506832A (ja) 1995-07-27
EP0640086B1 (en) 1999-08-04
FI945363A (fi) 1994-11-14
IL105680A (en) 1998-01-04
FI945363A0 (fi) 1994-11-14
HU223663B1 (hu) 2004-11-29
KR950701634A (ko) 1995-04-28
NO302573B1 (no) 1998-03-23
CA2133963C (en) 1998-07-07
HUT71099A (en) 1995-11-28
DK0640086T3 (da) 1999-12-06
DE69325904D1 (de) 1999-09-09
US5366973A (en) 1994-11-22
NO944335L (no) 1995-01-13
IL105680A0 (en) 1993-09-22
FI108230B (fi) 2001-12-14
CA2133963A1 (en) 1993-11-25
ATE182892T1 (de) 1999-08-15
ES2138622T3 (es) 2000-01-16
KR100281450B1 (ko) 2001-02-01
JP3360079B2 (ja) 2002-12-24
WO1993023403A1 (en) 1993-11-25
AU669364B2 (en) 1996-06-06

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