ES8505658A1 - Procedimiento para preparar pirazol(aril)metanonas - Google Patents

Procedimiento para preparar pirazol(aril)metanonas

Info

Publication number
ES8505658A1
ES8505658A1 ES533653A ES533653A ES8505658A1 ES 8505658 A1 ES8505658 A1 ES 8505658A1 ES 533653 A ES533653 A ES 533653A ES 533653 A ES533653 A ES 533653A ES 8505658 A1 ES8505658 A1 ES 8505658A1
Authority
ES
Spain
Prior art keywords
aryl
methanones
pyrazol
amino
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533653A
Other languages
English (en)
Other versions
ES533653A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES533653A0 publication Critical patent/ES533653A0/es
Publication of ES8505658A1 publication Critical patent/ES8505658A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRAZOL(ARIL)METANONAS, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA FENILO SUSTITUIDO, PIRIDINILO O TIENILO; Y R2 SIGNIFICA HIDROGENO O ALQUILO.CONSISTE EN HACER REACCIONAR UN ACETONITRILO ADECUADAMENTE SUSTITUIDO, DE FORMULA GENERAL (II), CON UNA DIMETILACETAL DE N,N-DIMETILAMIDA, PARA OBTENER UN SOLIDO CRISTALINO, EL CUAL DESPUES DE SER RECUPERADO Y DISUELTO EN CLORURO DE METILENO, SE HACE PASAR A TRAVES DE UN SILICATO DE MAGNESIO HIDRATADO, PARA OBTENER UN PRECIPITADO DE FORMULA (III). DICHO PRECIPITADO SE HACE REACCIONAR CON UNA SAL DE AMINOGUANIDINA, PARA OBTENER EL PRODUCTO DESEADO.DE APLICACION EN MEDICINA COMO AGENTE ANSIOLITICO Y ANTIEPILEPTICO.
ES533653A 1983-06-23 1984-06-22 Procedimiento para preparar pirazol(aril)metanonas Expired ES8505658A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50731783A 1983-06-23 1983-06-23

Publications (2)

Publication Number Publication Date
ES533653A0 ES533653A0 (es) 1985-06-16
ES8505658A1 true ES8505658A1 (es) 1985-06-16

Family

ID=24018151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533653A Expired ES8505658A1 (es) 1983-06-23 1984-06-22 Procedimiento para preparar pirazol(aril)metanonas

Country Status (17)

Country Link
EP (1) EP0129846B1 (es)
JP (1) JPS6013764A (es)
KR (1) KR900001215B1 (es)
AT (1) ATE63307T1 (es)
AU (1) AU572157B2 (es)
CA (1) CA1243029A (es)
DD (1) DD223448A5 (es)
DE (2) DE3484549D1 (es)
DK (1) DK306884A (es)
ES (1) ES8505658A1 (es)
HK (1) HK15292A (es)
HU (1) HUT34956A (es)
IE (1) IE58013B1 (es)
NZ (1) NZ208555A (es)
PH (1) PH21579A (es)
SG (1) SG2292G (es)
ZA (1) ZA844771B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502935A1 (de) * 1984-09-29 1986-04-10 Bayer Ag, 5090 Leverkusen 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung
JPH01211582A (ja) * 1988-02-16 1989-08-24 Tanabe Seiyaku Co Ltd ベンゾジオキソール誘導体
GB8814881D0 (en) * 1988-06-22 1988-07-27 Shell Int Research Herbicidal acrylonitrile derivatives
GB8920519D0 (en) * 1989-09-11 1989-10-25 Rhone Poulenc Ltd New compositions of matter
US5650533A (en) * 1989-09-11 1997-07-22 Rhone-Poulenc Agriculture Ltd. Intermediates to herbicidal 4-substituted isoxazoles
US5656573A (en) * 1989-09-11 1997-08-12 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazoles
US5747424A (en) * 1989-09-11 1998-05-05 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazol
GB8928524D0 (en) * 1989-12-18 1990-02-21 Shell Int Research Herbicidal acrylonitrile derivatives
US5059709A (en) * 1990-11-13 1991-10-22 American Cyanamid Company Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
US5426089A (en) * 1990-11-21 1995-06-20 Shell Research Limited Herbicidal acrylonitrile derivatives
JP2549304Y2 (ja) * 1991-05-17 1997-09-30 エヌオーケー株式会社 ゴムコーティング素材の打抜き装置
US6316466B1 (en) 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
US6376527B1 (en) 1998-05-05 2002-04-23 Syntex (U.S.A.) Llc Pyrazole derivatives-p38 map kinase inhibitors
US20020156114A1 (en) 1998-05-05 2002-10-24 Goldstein David Michael Pyrazole derivatives - p38 MAP kinase inhibitors
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
KR100612079B1 (ko) * 2003-10-09 2006-08-11 주식회사 엘지화학 방사형 다분지 고분자 및 이를 이용한 다공성 막

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558605A (en) * 1969-05-14 1971-01-26 Parke Davis & Co Pyrazolo(3,4-e)(1,4)diazepin-7-(1h)-one compounds
AU451515B2 (en) * 1970-07-30 1974-08-08 Yoshitomi Pharmaceutical Industries, Ltd 5 aminopyrazole derivatives
JPS5140365B2 (es) * 1972-05-31 1976-11-02
FR2294699A1 (fr) * 1974-12-19 1976-07-16 Bottu Nouveaux derives du pyrazole et compositions pharmaceutiques les renfermant
US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
ES513399A0 (es) * 1981-06-26 1983-03-01 Warner Lambert Co Un procedimiento para preparar derivados de dialcohilpirazol
IT1154024B (it) * 1982-09-22 1987-01-21 Lepetit Spa Derivati pridinici e procedimento per la loro produzione
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use

Also Published As

Publication number Publication date
KR850000404A (ko) 1985-02-27
HK15292A (en) 1992-03-06
ZA844771B (en) 1985-02-27
JPH0469155B2 (es) 1992-11-05
DK306884D0 (da) 1984-06-22
IE841581L (en) 1984-12-23
KR900001215B1 (ko) 1990-02-28
PH21579A (en) 1987-12-11
JPS6013764A (ja) 1985-01-24
EP0129846A3 (en) 1987-04-22
AU2976984A (en) 1985-01-03
NZ208555A (en) 1987-06-30
ES533653A0 (es) 1985-06-16
AU572157B2 (en) 1988-05-05
HUT34956A (en) 1985-05-28
DK306884A (da) 1984-12-24
EP0129846B1 (en) 1991-05-08
EP0129846A2 (en) 1985-01-02
DE3484549D1 (de) 1991-06-13
ATE63307T1 (de) 1991-05-15
IE58013B1 (en) 1993-06-16
DD223448A5 (de) 1985-06-12
CA1243029A (en) 1988-10-11
SG2292G (en) 1992-03-20
DE3422876A1 (de) 1985-01-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612