ES8505682A1 - Metodo para preparar derivados de acidos b-carbolin-3-barboxilicos - Google Patents

Metodo para preparar derivados de acidos b-carbolin-3-barboxilicos

Info

Publication number
ES8505682A1
ES8505682A1 ES532836A ES532836A ES8505682A1 ES 8505682 A1 ES8505682 A1 ES 8505682A1 ES 532836 A ES532836 A ES 532836A ES 532836 A ES532836 A ES 532836A ES 8505682 A1 ES8505682 A1 ES 8505682A1
Authority
ES
Spain
Prior art keywords
carbolin
beta
carboxylic acid
acid derivatives
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532836A
Other languages
English (en)
Other versions
ES532836A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES532836A0 publication Critical patent/ES532836A0/es
Publication of ES8505682A1 publication Critical patent/ES8505682A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Testing Of Short-Circuits, Discontinuities, Leakage, Or Incorrect Line Connections (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDOS B-CARBOLIN-3-CARBOXILICOS DE FORMULA GENERAL (I).COMPRENDE CICLIZAR UN DERIVADO DE INDOL DE LA FORMULA (II) EN DONDE R ES HIDROGENO, METILO, ETILO, N-PROPILO O ISO-PROPILO Y R ES HIDROGENO, METILO, ETILO, N-PROPILO O ISO-PROPILO, CON LA CONDICION DE QUE R NO ES METILO CUANDO R ES HIDROGENO, CON ACIDO GLIOXILICO O FORMALDEHIDO, Y DESPUES DE ELLOS DESHIDROGENIZAR EL DERIVADO DE 1,2,3,4-TETRAHIDROCARBOLINA OBTENIDO COMO COMPUESTO INTERMEDIO Y SI R ES HIDROGENO, SEGUIDO POR ETERIFICAR EL GRUPO HIDROXILO POR REACCION CON UN COMPUESTO DE FORMULA GENERAL RX, EN DONDE R ES METILO, ETILO, N-PROPILO O ISO-PROPILO Y X REPRESENTA UN ATOMO DE HALOGENO.
ES532836A 1983-05-27 1984-05-25 Metodo para preparar derivados de acidos b-carbolin-3-barboxilicos Expired ES8505682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK240283A DK149270C (da) 1983-05-27 1983-05-27 Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater

Publications (2)

Publication Number Publication Date
ES532836A0 ES532836A0 (es) 1985-06-16
ES8505682A1 true ES8505682A1 (es) 1985-06-16

Family

ID=8112124

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532836A Expired ES8505682A1 (es) 1983-05-27 1984-05-25 Metodo para preparar derivados de acidos b-carbolin-3-barboxilicos

Country Status (15)

Country Link
US (1) US4748179A (es)
EP (1) EP0128415B1 (es)
JP (1) JPH089614B2 (es)
AT (1) ATE36853T1 (es)
AU (1) AU567163B2 (es)
CA (1) CA1256877A (es)
DE (1) DE3473759D1 (es)
DK (1) DK149270C (es)
ES (1) ES8505682A1 (es)
FI (1) FI79108C (es)
GR (1) GR81580B (es)
HU (1) HU189904B (es)
IL (1) IL71887A (es)
NO (1) NO159854C (es)
ZA (1) ZA844003B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung
DE3535928A1 (de) * 1985-10-04 1987-04-09 Schering Ag Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
US5193732A (en) * 1991-10-04 1993-03-16 International Business Machines Corporation Apparatus and methods for making simultaneous electrical connections

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1084257A (es) * 1963-11-06
JPS5643283A (en) * 1979-08-29 1981-04-21 Schering Ag Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS574987A (en) * 1980-06-09 1982-01-11 Sankyo Co Ltd Pyridoindolecarboxylic acid derivative and its preparation
JPS6023627B2 (ja) * 1980-06-09 1985-06-08 和親 和田 柱状物用昇降器具
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240513A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung

Also Published As

Publication number Publication date
IL71887A0 (en) 1984-09-30
DK240283A (da) 1984-11-28
IL71887A (en) 1987-10-30
FI79108B (fi) 1989-07-31
DK149270C (da) 1986-08-25
ATE36853T1 (de) 1988-09-15
HU189904B (en) 1986-08-28
DK240283D0 (da) 1983-05-27
FI842112A (fi) 1984-11-28
ZA844003B (en) 1985-01-30
NO159854B (no) 1988-11-07
JPH089614B2 (ja) 1996-01-31
EP0128415A3 (en) 1985-12-18
FI79108C (fi) 1989-11-10
FI842112A0 (fi) 1984-05-25
DK149270B (da) 1986-04-14
CA1256877A (en) 1989-07-04
ES532836A0 (es) 1985-06-16
US4748179A (en) 1988-05-31
EP0128415B1 (en) 1988-08-31
AU2847084A (en) 1984-11-29
HUT34483A (en) 1985-03-28
EP0128415A2 (en) 1984-12-19
NO842014L (no) 1984-11-28
JPS6041676A (ja) 1985-03-05
DE3473759D1 (en) 1988-10-06
NO159854C (no) 1989-02-15
AU567163B2 (en) 1987-11-12
GR81580B (es) 1984-12-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601