FI945363A - Uusia merkaptoasetyyliamidopyridatso (1,2)pyridatsiini-, pyratsolo(1,2)pyridatsiini-, pyridatso (1,2-a)(1,2)diatsepiini- ja pyratsolo(1,2-a)(1,2)diatsepiinijohdannaisia, jotka ovat käyttökelpoisia enkefalisaasin ja ACE:n estäjinä - Google Patents

Uusia merkaptoasetyyliamidopyridatso (1,2)pyridatsiini-, pyratsolo(1,2)pyridatsiini-, pyridatso (1,2-a)(1,2)diatsepiini- ja pyratsolo(1,2-a)(1,2)diatsepiinijohdannaisia, jotka ovat käyttökelpoisia enkefalisaasin ja ACE:n estäjinä Download PDF

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Publication number
FI945363A
FI945363A FI945363A FI945363A FI945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A
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FI
Finland
Prior art keywords
pyrazolo
pyridazine
diazepine
pyridazo
ace
Prior art date
Application number
FI945363A
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English (en)
Swedish (sv)
Other versions
FI945363A0 (fi
FI108230B (fi
Inventor
Gary Alan Flynn
Patrick Wai-Kwok Shum
Original Assignee
Merrell Dow Pharma
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Publication date
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Publication of FI945363A0 publication Critical patent/FI945363A0/fi
Publication of FI945363A publication Critical patent/FI945363A/fi
Application granted granted Critical
Publication of FI108230B publication Critical patent/FI108230B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI945363A 1992-05-15 1994-11-14 Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä FI108230B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US88496392 1992-05-15
US4000393A 1993-04-09 1993-04-09
US4000393 1993-04-09
US9303721 1993-04-21
PCT/US1993/003721 WO1993023403A1 (en) 1992-05-15 1993-04-21 NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

Publications (3)

Publication Number Publication Date
FI945363A0 FI945363A0 (fi) 1994-11-14
FI945363A true FI945363A (fi) 1994-11-14
FI108230B FI108230B (fi) 2001-12-14

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945363A FI108230B (fi) 1992-05-15 1994-11-14 Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä

Country Status (19)

Country Link
US (1) US5366973A (fi)
EP (1) EP0640086B1 (fi)
JP (1) JP3360079B2 (fi)
KR (1) KR100281450B1 (fi)
AT (1) ATE182892T1 (fi)
AU (1) AU669364B2 (fi)
CA (1) CA2133963C (fi)
DE (1) DE69325904T2 (fi)
DK (1) DK0640086T3 (fi)
ES (1) ES2138622T3 (fi)
FI (1) FI108230B (fi)
GR (1) GR3031287T3 (fi)
HU (1) HU223663B1 (fi)
IL (1) IL105680A (fi)
MX (1) MX9302824A (fi)
NO (1) NO302573B1 (fi)
NZ (1) NZ251930A (fi)
TW (1) TW270115B (fi)
WO (1) WO1993023403A1 (fi)

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Also Published As

Publication number Publication date
AU669364B2 (en) 1996-06-06
CA2133963C (en) 1998-07-07
IL105680A0 (en) 1993-09-22
KR950701634A (ko) 1995-04-28
TW270115B (fi) 1996-02-11
GR3031287T3 (en) 1999-12-31
NO944335D0 (no) 1994-11-14
DE69325904T2 (de) 1999-12-09
ATE182892T1 (de) 1999-08-15
HU223663B1 (hu) 2004-11-29
FI945363A0 (fi) 1994-11-14
NZ251930A (en) 1996-02-27
DE69325904D1 (de) 1999-09-09
EP0640086B1 (en) 1999-08-04
NO302573B1 (no) 1998-03-23
AU4033293A (en) 1993-12-13
US5366973A (en) 1994-11-22
JPH07506832A (ja) 1995-07-27
NO944335L (no) 1995-01-13
MX9302824A (es) 1994-05-31
CA2133963A1 (en) 1993-11-25
FI108230B (fi) 2001-12-14
EP0640086A1 (en) 1995-03-01
JP3360079B2 (ja) 2002-12-24
ES2138622T3 (es) 2000-01-16
HUT71099A (en) 1995-11-28
DK0640086T3 (da) 1999-12-06
WO1993023403A1 (en) 1993-11-25
KR100281450B1 (ko) 2001-02-01
IL105680A (en) 1998-01-04

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