FI945363A - Uusia merkaptoasetyyliamidopyridatso (1,2)pyridatsiini-, pyratsolo(1,2)pyridatsiini-, pyridatso (1,2-a)(1,2)diatsepiini- ja pyratsolo(1,2-a)(1,2)diatsepiinijohdannaisia, jotka ovat käyttökelpoisia enkefalisaasin ja ACE:n estäjinä - Google Patents
Uusia merkaptoasetyyliamidopyridatso (1,2)pyridatsiini-, pyratsolo(1,2)pyridatsiini-, pyridatso (1,2-a)(1,2)diatsepiini- ja pyratsolo(1,2-a)(1,2)diatsepiinijohdannaisia, jotka ovat käyttökelpoisia enkefalisaasin ja ACE:n estäjinä Download PDFInfo
- Publication number
- FI945363A FI945363A FI945363A FI945363A FI945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A
- Authority
- FI
- Finland
- Prior art keywords
- pyrazolo
- pyridazine
- diazepine
- pyridazo
- ace
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88496392A | 1992-05-15 | 1992-05-15 | |
US88496392 | 1992-05-15 | ||
US4000393A | 1993-04-09 | 1993-04-09 | |
US4000393 | 1993-04-09 | ||
US9303721 | 1993-04-21 | ||
PCT/US1993/003721 WO1993023403A1 (en) | 1992-05-15 | 1993-04-21 | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
Publications (3)
Publication Number | Publication Date |
---|---|
FI945363A0 FI945363A0 (fi) | 1994-11-14 |
FI945363A true FI945363A (fi) | 1994-11-14 |
FI108230B FI108230B (fi) | 2001-12-14 |
Family
ID=26716641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI945363A FI108230B (fi) | 1992-05-15 | 1994-11-14 | Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä |
Country Status (19)
Country | Link |
---|---|
US (1) | US5366973A (fi) |
EP (1) | EP0640086B1 (fi) |
JP (1) | JP3360079B2 (fi) |
KR (1) | KR100281450B1 (fi) |
AT (1) | ATE182892T1 (fi) |
AU (1) | AU669364B2 (fi) |
CA (1) | CA2133963C (fi) |
DE (1) | DE69325904T2 (fi) |
DK (1) | DK0640086T3 (fi) |
ES (1) | ES2138622T3 (fi) |
FI (1) | FI108230B (fi) |
GR (1) | GR3031287T3 (fi) |
HU (1) | HU223663B1 (fi) |
IL (1) | IL105680A (fi) |
MX (1) | MX9302824A (fi) |
NO (1) | NO302573B1 (fi) |
NZ (1) | NZ251930A (fi) |
TW (1) | TW270115B (fi) |
WO (1) | WO1993023403A1 (fi) |
Families Citing this family (56)
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US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
KR0156780B1 (ko) * | 1993-06-11 | 1998-11-16 | 나이토 하루오 | 아미노산 유도체 |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
HUT74584A (en) * | 1994-02-14 | 1997-01-28 | Merrell Pharma Inc | Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them |
CN1142831A (zh) * | 1994-02-14 | 1997-02-12 | 默里尔药物公司 | 用作脑啡肽酶和ace抑制剂的新的2-取代的1,2-二氢化茚-2-巯基乙酰胺二硫化物衍生物 |
ATE191485T1 (de) * | 1994-02-14 | 2000-04-15 | Merrell Pharma Inc | Mercaptoacetylamid-1,3,4,5- tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren |
DE69514912T2 (de) * | 1994-03-24 | 2000-10-05 | Merrell Pharmaceuticals Inc., Cincinnati | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US6117896A (en) * | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
EP1053246B1 (en) * | 1998-02-12 | 2003-01-02 | Molecumetics, Ltd. | Beta-sheet mimetics and methods relating to the use thereof |
IT1298268B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
FR2777889B1 (fr) | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
PT1087775E (pt) | 1998-06-17 | 2005-11-30 | Bristol Myers Squibb Co | Prevencao de enfarte cerebral por administracao de uma combinacao de farmacos antiplaquetarios bloqueadores de receptores de adp e anti-hipertensivos |
US6177565B1 (en) | 1998-08-19 | 2001-01-23 | Vertex Pharmaceuticals Inc. | Process for synthesizing piperazic acid |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
ES2246894T3 (es) * | 1999-08-30 | 2006-03-01 | Sanofi-Aventis Deutschland Gmbh | Ramipril para la prevencion de sucesos cardiovasculares. |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
US6984645B2 (en) * | 2001-11-16 | 2006-01-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
EP1482941A4 (en) | 2002-02-14 | 2006-04-12 | Myriad Genetics Inc | BETA-SHEET MIMETIKA AND COMPOSITION AND RELEVANT PROCEDURES |
US7459474B2 (en) * | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7273881B2 (en) | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
EP1906934A4 (en) * | 2005-07-14 | 2012-03-07 | Franco Folli | DAILY DOSAGE SCHEME FOR THE TREATMENT OF DIABETES, OBESITY, METABOLIC SYNDROME AND POLYKYSTIC OVAIRE SYNDROME |
US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
US20070238770A1 (en) * | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
EA200870575A1 (ru) | 2006-05-26 | 2009-08-28 | Амилин Фармасьютикалз, Инк. | Композиции и способы лечения застойной сердечной недостаточности |
US7795291B2 (en) | 2006-07-07 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method |
US7968577B2 (en) | 2006-11-01 | 2011-06-28 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
WO2008057857A1 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
WO2008057855A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity |
CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2009042922A2 (en) | 2007-09-27 | 2009-04-02 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of making and using same |
WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CN102149710A (zh) | 2008-06-24 | 2011-08-10 | 百时美施贵宝公司 | 糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途 |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
WO2015027021A1 (en) | 2013-08-22 | 2015-02-26 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
CN106674228B (zh) * | 2016-12-09 | 2018-12-04 | 河南农业大学 | 多元杂环化合物及其制备方法和用途 |
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US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
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ZA833214B (en) * | 1982-05-12 | 1983-12-28 | Hoffmann La Roche | Bicyclic compounds |
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US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
ZA874107B (fi) * | 1986-06-13 | 1987-12-09 | ||
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
AU7168091A (en) * | 1989-12-22 | 1991-07-24 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
EP0492369B1 (en) * | 1990-12-21 | 1997-09-17 | Merrell Pharmaceuticals Inc. | Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
EP0605589A1 (en) * | 1991-09-16 | 1994-07-13 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
-
1993
- 1993-04-21 AU AU40332/93A patent/AU669364B2/en not_active Ceased
- 1993-04-21 NZ NZ251930A patent/NZ251930A/en unknown
- 1993-04-21 DK DK93909605T patent/DK0640086T3/da active
- 1993-04-21 HU HU9403266A patent/HU223663B1/hu not_active IP Right Cessation
- 1993-04-21 KR KR1019940704065A patent/KR100281450B1/ko not_active IP Right Cessation
- 1993-04-21 AT AT93909605T patent/ATE182892T1/de not_active IP Right Cessation
- 1993-04-21 WO PCT/US1993/003721 patent/WO1993023403A1/en active IP Right Grant
- 1993-04-21 ES ES93909605T patent/ES2138622T3/es not_active Expired - Lifetime
- 1993-04-21 JP JP52023593A patent/JP3360079B2/ja not_active Expired - Fee Related
- 1993-04-21 DE DE69325904T patent/DE69325904T2/de not_active Expired - Fee Related
- 1993-04-21 EP EP93909605A patent/EP0640086B1/en not_active Expired - Lifetime
- 1993-04-21 CA CA002133963A patent/CA2133963C/en not_active Expired - Fee Related
- 1993-05-11 TW TW082103682A patent/TW270115B/zh active
- 1993-05-12 IL IL105680A patent/IL105680A/en not_active IP Right Cessation
- 1993-05-14 MX MX9302824A patent/MX9302824A/es not_active IP Right Cessation
- 1993-11-03 US US08/146,857 patent/US5366973A/en not_active Expired - Fee Related
-
1994
- 1994-11-14 NO NO944335A patent/NO302573B1/no not_active IP Right Cessation
- 1994-11-14 FI FI945363A patent/FI108230B/fi not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402385T patent/GR3031287T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU669364B2 (en) | 1996-06-06 |
CA2133963C (en) | 1998-07-07 |
IL105680A0 (en) | 1993-09-22 |
KR950701634A (ko) | 1995-04-28 |
TW270115B (fi) | 1996-02-11 |
GR3031287T3 (en) | 1999-12-31 |
NO944335D0 (no) | 1994-11-14 |
DE69325904T2 (de) | 1999-12-09 |
ATE182892T1 (de) | 1999-08-15 |
HU223663B1 (hu) | 2004-11-29 |
FI945363A0 (fi) | 1994-11-14 |
NZ251930A (en) | 1996-02-27 |
DE69325904D1 (de) | 1999-09-09 |
EP0640086B1 (en) | 1999-08-04 |
NO302573B1 (no) | 1998-03-23 |
AU4033293A (en) | 1993-12-13 |
US5366973A (en) | 1994-11-22 |
JPH07506832A (ja) | 1995-07-27 |
NO944335L (no) | 1995-01-13 |
MX9302824A (es) | 1994-05-31 |
CA2133963A1 (en) | 1993-11-25 |
FI108230B (fi) | 2001-12-14 |
EP0640086A1 (en) | 1995-03-01 |
JP3360079B2 (ja) | 2002-12-24 |
ES2138622T3 (es) | 2000-01-16 |
HUT71099A (en) | 1995-11-28 |
DK0640086T3 (da) | 1999-12-06 |
WO1993023403A1 (en) | 1993-11-25 |
KR100281450B1 (ko) | 2001-02-01 |
IL105680A (en) | 1998-01-04 |
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