ATE231863T1 - 6-amino-purinderivate mit pde-iv inhibierender wirkung - Google Patents
6-amino-purinderivate mit pde-iv inhibierender wirkungInfo
- Publication number
- ATE231863T1 ATE231863T1 AT99100736T AT99100736T ATE231863T1 AT E231863 T1 ATE231863 T1 AT E231863T1 AT 99100736 T AT99100736 T AT 99100736T AT 99100736 T AT99100736 T AT 99100736T AT E231863 T1 ATE231863 T1 AT E231863T1
- Authority
- AT
- Austria
- Prior art keywords
- purine derivatives
- amino
- pde
- inhibiting effect
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939312853A GB9312853D0 (en) | 1993-06-22 | 1993-06-22 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231863T1 true ATE231863T1 (de) | 2003-02-15 |
Family
ID=10737574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99100736T ATE231863T1 (de) | 1993-06-22 | 1994-06-21 | 6-amino-purinderivate mit pde-iv inhibierender wirkung |
| AT94918456T ATE182593T1 (de) | 1993-06-22 | 1994-06-21 | Chemische verbindungen mit pde-iv inhibitierende wirkung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94918456T ATE182593T1 (de) | 1993-06-22 | 1994-06-21 | Chemische verbindungen mit pde-iv inhibitierende wirkung |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5939422A (de) |
| EP (3) | EP0705265B1 (de) |
| JP (1) | JP3350550B2 (de) |
| KR (1) | KR100349239B1 (de) |
| CN (1) | CN1045778C (de) |
| AT (2) | ATE231863T1 (de) |
| AU (1) | AU683270B2 (de) |
| BG (1) | BG62933B1 (de) |
| CA (1) | CA2165433C (de) |
| CZ (1) | CZ342595A3 (de) |
| DE (2) | DE69419755T2 (de) |
| DK (1) | DK0705265T3 (de) |
| ES (1) | ES2137371T3 (de) |
| FI (1) | FI956168A (de) |
| GB (1) | GB9312853D0 (de) |
| HU (1) | HUT74176A (de) |
| NO (1) | NO955219L (de) |
| NZ (1) | NZ267468A (de) |
| PL (1) | PL312225A1 (de) |
| SK (1) | SK161095A3 (de) |
| TW (1) | TW418208B (de) |
| WO (1) | WO1995000516A1 (de) |
| ZA (1) | ZA944463B (de) |
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| EP0814809B1 (de) | 1994-12-13 | 2003-08-13 | Euroceltique S.A. | Arylthioxanthine |
| DE69531555T2 (de) * | 1994-12-13 | 2004-06-17 | Euroceltique S.A. | Dreifachsubstituierte thioxanthine |
| US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
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| DE69824632T2 (de) | 1997-11-12 | 2005-06-09 | Mitsubishi Chemical Corp. | Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten |
| AU1722999A (en) | 1997-12-12 | 1999-07-05 | Euro-Celtique S.A. | Preparation of 3-substituted adenines and imidazo pyridines |
| US6319928B1 (en) | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| AU4053800A (en) * | 1999-04-02 | 2000-10-23 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase iv inhibition activity |
| WO2000068231A1 (fr) | 1999-05-11 | 2000-11-16 | Mitsubishi Chemical Corporation | Dihydrate derive de purine, medicaments le contenant comme principe actif et intermediaire utilise dans sa preparation |
| DE60014915T2 (de) * | 1999-08-12 | 2005-10-13 | Euro-Celtique S.A. | Hypoxanthin- und thiohypxanthin-verbindungen |
| WO2002098878A1 (en) * | 2001-02-08 | 2002-12-12 | Memory Pharmaceuticals Corporation | Trifluoromethylpurines as phosphodiesterase 4 inhibitors |
| KR20040007583A (ko) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 연골 질환의 재생치료용 조성물 |
| MXPA03010679A (es) | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Una composicion para acelerar la cicatrizacion de fractura osea. |
| AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| CN100415747C (zh) * | 2002-08-08 | 2008-09-03 | 记忆药物公司 | 磷酸二酯酶4抑制剂 |
| CN1688580A (zh) * | 2002-08-08 | 2005-10-26 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的2－三氟甲基－6－氨基嘌呤衍生物 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| TW200806667A (en) * | 2006-04-13 | 2008-02-01 | Astrazeneca Ab | New compounds |
| WO2007120097A1 (en) * | 2006-04-13 | 2007-10-25 | Astrazeneca Ab | Thioxanthine derivatives and their use as inhibitors of mpo |
| DK3421471T3 (da) | 2006-04-25 | 2021-06-14 | Astex Therapeutics Ltd | Purin- og deazapurinderivater som farmaceutiske forbindelser |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| TW200902025A (en) * | 2007-04-11 | 2009-01-16 | Alcon Res Ltd | Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MY150059A (en) | 2007-10-11 | 2013-11-29 | Astrazeneca Ab | Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors |
| EP3239170B1 (de) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| EP3241839B1 (de) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
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| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| EP2694056B1 (de) | 2011-04-01 | 2019-10-16 | AstraZeneca AB | Therapeutische behandlung |
| WO2013079964A1 (en) | 2011-11-30 | 2013-06-06 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| IL280864B2 (en) | 2013-08-09 | 2024-03-01 | Ardelyx Inc | Compounds and methods for inhibiting phosphate transport |
| EP3165224A1 (de) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Verwendung von pde4 hemmern zur prophylaxe und/oder therapie von dyslipoproteinaemie und verwandten erkrankungen |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
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-
1993
- 1993-06-22 GB GB939312853A patent/GB9312853D0/en active Pending
-
1994
- 1994-06-21 DE DE69419755T patent/DE69419755T2/de not_active Expired - Fee Related
- 1994-06-21 HU HU9503545A patent/HUT74176A/hu unknown
- 1994-06-21 JP JP50257095A patent/JP3350550B2/ja not_active Expired - Fee Related
- 1994-06-21 DK DK94918456T patent/DK0705265T3/da active
- 1994-06-21 CN CN94192521A patent/CN1045778C/zh not_active Expired - Fee Related
- 1994-06-21 SK SK1610-95A patent/SK161095A3/sk unknown
- 1994-06-21 NZ NZ267468A patent/NZ267468A/en unknown
- 1994-06-21 CA CA002165433A patent/CA2165433C/en not_active Expired - Fee Related
- 1994-06-21 CZ CZ953425A patent/CZ342595A3/cs unknown
- 1994-06-21 DE DE69432087T patent/DE69432087T2/de not_active Expired - Fee Related
- 1994-06-21 WO PCT/GB1994/001334 patent/WO1995000516A1/en not_active Application Discontinuation
- 1994-06-21 EP EP94918456A patent/EP0705265B1/de not_active Expired - Lifetime
- 1994-06-21 AU AU69771/94A patent/AU683270B2/en not_active Ceased
- 1994-06-21 US US08/578,580 patent/US5939422A/en not_active Expired - Lifetime
- 1994-06-21 KR KR1019950705789A patent/KR100349239B1/ko not_active IP Right Cessation
- 1994-06-21 EP EP99100735A patent/EP0916672A1/de not_active Withdrawn
- 1994-06-21 AT AT99100736T patent/ATE231863T1/de not_active IP Right Cessation
- 1994-06-21 AT AT94918456T patent/ATE182593T1/de not_active IP Right Cessation
- 1994-06-21 ES ES94918456T patent/ES2137371T3/es not_active Expired - Lifetime
- 1994-06-21 PL PL94312225A patent/PL312225A1/xx unknown
- 1994-06-21 EP EP99100736A patent/EP0916673B1/de not_active Expired - Lifetime
- 1994-06-22 ZA ZA944463A patent/ZA944463B/xx unknown
- 1994-08-02 TW TW083107047A patent/TW418208B/zh active
-
1995
- 1995-12-21 NO NO955219A patent/NO955219L/no not_active Application Discontinuation
- 1995-12-21 FI FI956168A patent/FI956168A/fi not_active IP Right Cessation
- 1995-12-27 BG BG100258A patent/BG62933B1/bg unknown
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