ATE231863T1 - 6-amino-purinderivate mit pde-iv inhibierender wirkung - Google Patents

6-amino-purinderivate mit pde-iv inhibierender wirkung

Info

Publication number
ATE231863T1
ATE231863T1 AT99100736T AT99100736T ATE231863T1 AT E231863 T1 ATE231863 T1 AT E231863T1 AT 99100736 T AT99100736 T AT 99100736T AT 99100736 T AT99100736 T AT 99100736T AT E231863 T1 ATE231863 T1 AT E231863T1
Authority
AT
Austria
Prior art keywords
purine derivatives
amino
pde
inhibiting effect
compounds
Prior art date
Application number
AT99100736T
Other languages
English (en)
Inventor
David Cavalla
Peter Hofer
Anddre Gehrig
Peter Wintergest
Mark Chasin
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE231863T1 publication Critical patent/ATE231863T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99100736T 1993-06-22 1994-06-21 6-amino-purinderivate mit pde-iv inhibierender wirkung ATE231863T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939312853A GB9312853D0 (en) 1993-06-22 1993-06-22 Chemical compounds

Publications (1)

Publication Number Publication Date
ATE231863T1 true ATE231863T1 (de) 2003-02-15

Family

ID=10737574

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94918456T ATE182593T1 (de) 1993-06-22 1994-06-21 Chemische verbindungen mit pde-iv inhibitierende wirkung
AT99100736T ATE231863T1 (de) 1993-06-22 1994-06-21 6-amino-purinderivate mit pde-iv inhibierender wirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94918456T ATE182593T1 (de) 1993-06-22 1994-06-21 Chemische verbindungen mit pde-iv inhibitierende wirkung

Country Status (23)

Country Link
US (1) US5939422A (de)
EP (3) EP0916672A1 (de)
JP (1) JP3350550B2 (de)
KR (1) KR100349239B1 (de)
CN (1) CN1045778C (de)
AT (2) ATE182593T1 (de)
AU (1) AU683270B2 (de)
BG (1) BG62933B1 (de)
CA (1) CA2165433C (de)
CZ (1) CZ342595A3 (de)
DE (2) DE69419755T2 (de)
DK (1) DK0705265T3 (de)
ES (1) ES2137371T3 (de)
FI (1) FI956168L (de)
GB (1) GB9312853D0 (de)
HU (1) HUT74176A (de)
NO (1) NO955219L (de)
NZ (1) NZ267468A (de)
PL (1) PL312225A1 (de)
SK (1) SK161095A3 (de)
TW (1) TW418208B (de)
WO (1) WO1995000516A1 (de)
ZA (1) ZA944463B (de)

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US6319928B1 (en) 1998-11-30 2001-11-20 Euro-Celtique, S.A. Purine derivatives having phosphodiesterase IV inhibition activity
KR20020065341A (ko) * 1999-04-02 2002-08-13 유로-셀티크 소시에떼 아노뉨 포스포디에스트라스(phosphodiesterase, PDE) Ⅳ 억제작용을 가진 푸린 유도체
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GB9312853D0 (en) 1993-08-04
HU9503545D0 (en) 1996-02-28
EP0916673A1 (de) 1999-05-19
AU683270B2 (en) 1997-11-06
DE69419755T2 (de) 2000-02-17
EP0916673B1 (de) 2003-01-29
DE69419755D1 (de) 1999-09-02
DE69432087T2 (de) 2003-11-06
BG62933B1 (bg) 2000-11-30
NO955219L (no) 1996-02-22
JPH09500376A (ja) 1997-01-14
CN1045778C (zh) 1999-10-20
EP0705265A1 (de) 1996-04-10
FI956168A7 (fi) 1996-02-01
WO1995000516A1 (en) 1995-01-05
ZA944463B (en) 1995-02-17
KR100349239B1 (ko) 2003-01-24
HUT74176A (en) 1996-11-28
CN1125445A (zh) 1996-06-26
DE69432087D1 (de) 2003-03-06
CZ342595A3 (en) 1996-08-14
BG100258A (bg) 1996-11-29
FI956168A0 (fi) 1995-12-21
EP0705265B1 (de) 1999-07-28
NZ267468A (en) 1997-11-24
JP3350550B2 (ja) 2002-11-25
TW418208B (en) 2001-01-11
US5939422A (en) 1999-08-17
CA2165433A1 (en) 1994-12-23
NO955219D0 (no) 1995-12-21
PL312225A1 (en) 1996-04-01
FI956168L (fi) 1996-02-01
KR960703124A (ko) 1996-06-19
ES2137371T3 (es) 1999-12-16
CA2165433C (en) 2002-05-28
AU6977194A (en) 1995-01-17
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ATE182593T1 (de) 1999-08-15
SK161095A3 (en) 1997-01-08

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