DE69520364D1 - Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate-aufnahme - Google Patents

Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate-aufnahme

Info

Publication number
DE69520364D1
DE69520364D1 DE69520364T DE69520364T DE69520364D1 DE 69520364 D1 DE69520364 D1 DE 69520364D1 DE 69520364 T DE69520364 T DE 69520364T DE 69520364 T DE69520364 T DE 69520364T DE 69520364 D1 DE69520364 D1 DE 69520364D1
Authority
DE
Germany
Prior art keywords
benzothepines
taurocholate
inhibitors
acquisition
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69520364T
Other languages
English (en)
Other versions
DE69520364T2 (de
Inventor
Fang Lee
Eugene Miller
Joseph Tremont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE69520364D1 publication Critical patent/DE69520364D1/de
Publication of DE69520364T2 publication Critical patent/DE69520364T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DE69520364T 1994-09-13 1995-08-28 Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate-aufnahme Expired - Fee Related DE69520364T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30552694A 1994-09-13 1994-09-13
PCT/US1995/010863 WO1996008484A1 (en) 1994-09-13 1995-08-28 Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Publications (2)

Publication Number Publication Date
DE69520364D1 true DE69520364D1 (de) 2001-04-19
DE69520364T2 DE69520364T2 (de) 2001-09-13

Family

ID=23181154

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69520364T Expired - Fee Related DE69520364T2 (de) 1994-09-13 1995-08-28 Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate-aufnahme

Country Status (13)

Country Link
EP (1) EP0781278B1 (de)
JP (1) JP3304093B2 (de)
CN (1) CN1084741C (de)
AT (1) ATE199718T1 (de)
AU (1) AU700557B2 (de)
BR (1) BR9508916A (de)
CA (1) CA2199944A1 (de)
DE (1) DE69520364T2 (de)
DK (1) DK0781278T3 (de)
ES (1) ES2155136T3 (de)
GR (1) GR3035583T3 (de)
PT (1) PT781278E (de)
WO (1) WO1996008484A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
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ZA956647B (en) * 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
EP1440972A1 (de) * 1996-03-11 2004-07-28 G.D. Searle & Co. Neue Benzothiepine mit pharmazeutischer Wirkung.
KR19990087721A (ko) * 1996-03-11 1999-12-27 지.디. 썰 앤드 컴파니 회장 담즙산 운반 및 타우로콜레이트 흡수 저해제로서의 활성을 갖는 신규한 벤조티에핀
CN1110494C (zh) * 1996-03-11 2003-06-04 G·D·瑟尔公司 具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因
GB9704208D0 (en) * 1997-02-28 1997-04-16 Glaxo Group Ltd Chemical compounds
EP1331225A1 (de) * 1997-12-19 2003-07-30 G.D. Searle & Co. Verfahren zur Herstellung von enantiomer-angereicherten Tetrahydrobenzothiepin Oxyden
WO1999032478A1 (en) 1997-12-19 1999-07-01 G.D. Searle & Co. Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
DE19825804C2 (de) * 1998-06-10 2000-08-24 Aventis Pharma Gmbh 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CA2356158C (en) 1998-12-23 2008-09-02 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
CN1338945A (zh) 1998-12-23 2002-03-06 G·D·瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合
EP1340509A1 (de) 1998-12-23 2003-09-03 G.D. Searle LLC. Kombinationen von Cholesteryl-Ester-Transfer-Protein-Inhibitoren und Fibrinsäure-Derivaten für kardiovaskuläre Indikationen
NZ512532A (en) * 1998-12-23 2003-12-19 G Combinations for treating cardiovascular diseases like hypercholesterolemia and atherosclerosis
CZ20012342A3 (cs) 1998-12-23 2001-12-12 G. D. Searle Llc Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny fibrové pro kardiovaskulární indikace
HUP0201972A3 (en) 1998-12-23 2005-06-28 G D Searle Llc Chicago Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
US6569905B1 (en) 1998-12-23 2003-05-27 G.D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
EP1184381A4 (de) * 1999-05-18 2003-03-12 Takeda Chemical Industries Ltd Verfahren zur herstellung von 2,3-dihydrothiepin-derivaten
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
JP2003528830A (ja) 2000-03-10 2003-09-30 ファルマシア・コーポレーション テトラヒドロベンゾチエピン類の製造方法
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JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
DE1593760A1 (de) * 1967-02-01 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Benz-epinderivate
AU626881B2 (en) * 1988-07-14 1992-08-13 F. Hoffmann-La Roche Ag Benzofused heterocyclics used as pharmaceuticals
FR2661676A1 (fr) * 1990-05-02 1991-11-08 Lipha Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
JPH0825973B2 (ja) * 1991-04-12 1996-03-13 シェリング・コーポレーション アシル補酵素ａ：コレステロールアシルトランスフェラーゼの阻害剤としての二環式アミド
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
FR2698873B1 (fr) * 1992-12-07 1995-02-24 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
DE102018100125A1 (de) * 2018-01-04 2019-07-04 Miele & Cie. Kg Wasserzulaufsteuerung und Waschautomat

Also Published As

Publication number Publication date
EP0781278A1 (de) 1997-07-02
DE69520364T2 (de) 2001-09-13
ES2155136T3 (es) 2001-05-01
CN1162311A (zh) 1997-10-15
BR9508916A (pt) 1997-12-30
EP0781278B1 (de) 2001-03-14
AU700557B2 (en) 1999-01-07
CN1084741C (zh) 2002-05-15
JP3304093B2 (ja) 2002-07-22
DK0781278T3 (da) 2001-04-17
ATE199718T1 (de) 2001-03-15
WO1996008484A1 (en) 1996-03-21
PT781278E (pt) 2001-08-30
CA2199944A1 (en) 1996-03-21
JPH10505830A (ja) 1998-06-09
GR3035583T3 (en) 2001-06-29
AU3373695A (en) 1996-03-29

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