ES2155136T3 - Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. - Google Patents

Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.

Info

Publication number
ES2155136T3
ES2155136T3 ES95930289T ES95930289T ES2155136T3 ES 2155136 T3 ES2155136 T3 ES 2155136T3 ES 95930289 T ES95930289 T ES 95930289T ES 95930289 T ES95930289 T ES 95930289T ES 2155136 T3 ES2155136 T3 ES 2155136T3
Authority
ES
Spain
Prior art keywords
illaco
benzotiepines
taurocolate
capturing
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930289T
Other languages
English (en)
Inventor
Len Fang Lee
Raymond Eugene Miller
Samuel Joseph Tremont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2155136T3 publication Critical patent/ES2155136T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS BENZOTIEPINAS, DERIVADOS Y ANALOGOS DE LAS MISMAS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU USO EN MEDICINA, EN PARTICULAR EN LA PROFILAXIS Y TRATAMIENTO DE CONDICIONES HIPERLIPIDEMICAS, COMO LAS ASOCIADAS CON ATEROSCLEROSIS, O HIPERCOLESTEROLEMIA, EN MAMIFEROS.
ES95930289T 1994-09-13 1995-08-28 Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. Expired - Lifetime ES2155136T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30552694A 1994-09-13 1994-09-13

Publications (1)

Publication Number Publication Date
ES2155136T3 true ES2155136T3 (es) 2001-05-01

Family

ID=23181154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930289T Expired - Lifetime ES2155136T3 (es) 1994-09-13 1995-08-28 Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.

Country Status (13)

Country Link
EP (1) EP0781278B1 (es)
JP (1) JP3304093B2 (es)
CN (1) CN1084741C (es)
AT (1) ATE199718T1 (es)
AU (1) AU700557B2 (es)
BR (1) BR9508916A (es)
CA (1) CA2199944A1 (es)
DE (1) DE69520364T2 (es)
DK (1) DK0781278T3 (es)
ES (1) ES2155136T3 (es)
GR (1) GR3035583T3 (es)
PT (1) PT781278E (es)
WO (1) WO1996008484A1 (es)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
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US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
AU723123B2 (en) * 1996-03-11 2000-08-17 G.D. Searle & Co. Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
RU2202549C2 (ru) * 1996-03-11 2003-04-20 Джи. Ди. Сирл Энд Ко. Бензотиепины, фармацевтическая композиция на их основе, способ профилактики или лечения гиперлипидемического состояния
EP1440972A1 (en) * 1996-03-11 2004-07-28 G.D. Searle & Co. Novel benzothiepines having pharmaceutical activity.
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EP1331225A1 (en) * 1997-12-19 2003-07-30 G.D. Searle & Co. Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
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EA005815B1 (ru) 1998-12-23 2005-06-30 Джи.Ди.Сирл Ллс Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
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Also Published As

Publication number Publication date
JP3304093B2 (ja) 2002-07-22
GR3035583T3 (en) 2001-06-29
ATE199718T1 (de) 2001-03-15
CN1162311A (zh) 1997-10-15
EP0781278B1 (en) 2001-03-14
AU3373695A (en) 1996-03-29
AU700557B2 (en) 1999-01-07
EP0781278A1 (en) 1997-07-02
CA2199944A1 (en) 1996-03-21
PT781278E (pt) 2001-08-30
BR9508916A (pt) 1997-12-30
WO1996008484A1 (en) 1996-03-21
CN1084741C (zh) 2002-05-15
DE69520364D1 (de) 2001-04-19
JPH10505830A (ja) 1998-06-09
DE69520364T2 (de) 2001-09-13
DK0781278T3 (da) 2001-04-17

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