NO955219L - Nye kjemiske forbindelser med PDE-IV-inhiberende aktivitet - Google Patents
Nye kjemiske forbindelser med PDE-IV-inhiberende aktivitetInfo
- Publication number
- NO955219L NO955219L NO955219A NO955219A NO955219L NO 955219 L NO955219 L NO 955219L NO 955219 A NO955219 A NO 955219A NO 955219 A NO955219 A NO 955219A NO 955219 L NO955219 L NO 955219L
- Authority
- NO
- Norway
- Prior art keywords
- pde
- inhibitory activity
- chemical compounds
- new chemical
- purine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Nye purinderivater og deres iso- guanin- og dithioxanthinforløper- forbinde]ser er beskrevet. Disse for- binde] ser har bronchial og tracheal relakserende og/e] l er anti-infl.amma- torisk aktivitet. Oppfinnelsen angår også fremgangsmåter for deres frem- stilling, farmasøytiske preparater inneholdende disse og deres medi- sinske anvendelse. I visse fore- trukne utførelsesformer angår opp- finnelsen 3-substituerte og 3,8- substituerte 6-aminopurinderivater.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939312853A GB9312853D0 (en) | 1993-06-22 | 1993-06-22 | Chemical compounds |
PCT/GB1994/001334 WO1995000516A1 (en) | 1993-06-22 | 1994-06-21 | Novel chemical compounds having pde-iv inhibition activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO955219D0 NO955219D0 (no) | 1995-12-21 |
NO955219L true NO955219L (no) | 1996-02-22 |
Family
ID=10737574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO955219A NO955219L (no) | 1993-06-22 | 1995-12-21 | Nye kjemiske forbindelser med PDE-IV-inhiberende aktivitet |
Country Status (23)
Country | Link |
---|---|
US (1) | US5939422A (no) |
EP (3) | EP0916673B1 (no) |
JP (1) | JP3350550B2 (no) |
KR (1) | KR100349239B1 (no) |
CN (1) | CN1045778C (no) |
AT (2) | ATE231863T1 (no) |
AU (1) | AU683270B2 (no) |
BG (1) | BG62933B1 (no) |
CA (1) | CA2165433C (no) |
CZ (1) | CZ342595A3 (no) |
DE (2) | DE69432087T2 (no) |
DK (1) | DK0705265T3 (no) |
ES (1) | ES2137371T3 (no) |
FI (1) | FI956168A (no) |
GB (1) | GB9312853D0 (no) |
HU (1) | HUT74176A (no) |
NO (1) | NO955219L (no) |
NZ (1) | NZ267468A (no) |
PL (1) | PL312225A1 (no) |
SK (1) | SK161095A3 (no) |
TW (1) | TW418208B (no) |
WO (1) | WO1995000516A1 (no) |
ZA (1) | ZA944463B (no) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996018399A1 (en) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Aryl thioxanthines |
AU4527996A (en) * | 1994-12-13 | 1996-07-03 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
US6294541B1 (en) | 1996-06-06 | 2001-09-25 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
US6413975B1 (en) * | 1999-04-02 | 2002-07-02 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase iv inhibition activity |
ES2222614T3 (es) | 1997-11-12 | 2005-02-01 | Mitsubishi Chemical Corporation | Derivados de purina y medicina que los contiene como ingrediente activo. |
US6057445A (en) | 1997-12-12 | 2000-05-02 | Euro-Celtique S.A. | Purine compounds having PDE IV inhibitory activity and methods of synthesis |
US6319928B1 (en) | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
DE60006663T2 (de) | 1999-05-11 | 2004-10-07 | Mitsubishi Chem Corp | Dihydrat eines purinderivates, medikamente die dieses als aktiven wirkstoff enthalten und zwischenprodukte zu dessen herstellung |
ATE279113T1 (de) * | 1999-08-12 | 2004-10-15 | Euro Celtique Sa | Hypoxanthin- und thiohypxanthin-verbindungen |
CN100439370C (zh) * | 2001-02-08 | 2008-12-03 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的三氟甲基嘌呤 |
CN1537018A (zh) * | 2001-05-23 | 2004-10-13 | 田边制药株式会社 | 一种用于软骨疾病再生治疗的组合物 |
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AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
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WO2004014911A1 (en) * | 2002-08-08 | 2004-02-19 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
CN101472926A (zh) * | 2006-04-13 | 2009-07-01 | 阿斯利康(瑞典)有限公司 | 硫代黄嘌呤衍生物以及它们作为髓过氧化物酶抑制剂的用途 |
WO2007125321A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
AR066016A1 (es) * | 2007-04-11 | 2009-07-15 | Alcon Res Ltd | Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica |
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US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
RS53552B1 (en) | 2007-10-11 | 2015-02-27 | Astrazeneca Ab | DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
CA2773483A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9580471B2 (en) | 2011-03-01 | 2017-02-28 | Synergy Pharmaceuticals, Inc. | Process of preparing guanylate cyclase C agonists |
AU2012235902B2 (en) | 2011-04-01 | 2015-08-27 | Astrazeneca Ab | Therapeutic treatment |
JP6309454B2 (ja) | 2011-11-30 | 2018-04-11 | アストラゼネカ アクチボラグ | 癌の併用処置 |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
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WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
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-
1993
- 1993-06-22 GB GB939312853A patent/GB9312853D0/en active Pending
-
1994
- 1994-06-21 US US08/578,580 patent/US5939422A/en not_active Expired - Lifetime
- 1994-06-21 SK SK1610-95A patent/SK161095A3/sk unknown
- 1994-06-21 EP EP99100736A patent/EP0916673B1/en not_active Expired - Lifetime
- 1994-06-21 CA CA002165433A patent/CA2165433C/en not_active Expired - Fee Related
- 1994-06-21 PL PL94312225A patent/PL312225A1/xx unknown
- 1994-06-21 EP EP99100735A patent/EP0916672A1/en not_active Withdrawn
- 1994-06-21 AU AU69771/94A patent/AU683270B2/en not_active Ceased
- 1994-06-21 CN CN94192521A patent/CN1045778C/zh not_active Expired - Fee Related
- 1994-06-21 KR KR1019950705789A patent/KR100349239B1/ko not_active IP Right Cessation
- 1994-06-21 EP EP94918456A patent/EP0705265B1/en not_active Expired - Lifetime
- 1994-06-21 DE DE69432087T patent/DE69432087T2/de not_active Expired - Fee Related
- 1994-06-21 NZ NZ267468A patent/NZ267468A/en unknown
- 1994-06-21 JP JP50257095A patent/JP3350550B2/ja not_active Expired - Fee Related
- 1994-06-21 DE DE69419755T patent/DE69419755T2/de not_active Expired - Fee Related
- 1994-06-21 ES ES94918456T patent/ES2137371T3/es not_active Expired - Lifetime
- 1994-06-21 DK DK94918456T patent/DK0705265T3/da active
- 1994-06-21 AT AT99100736T patent/ATE231863T1/de not_active IP Right Cessation
- 1994-06-21 AT AT94918456T patent/ATE182593T1/de not_active IP Right Cessation
- 1994-06-21 WO PCT/GB1994/001334 patent/WO1995000516A1/en not_active Application Discontinuation
- 1994-06-21 HU HU9503545A patent/HUT74176A/hu unknown
- 1994-06-21 CZ CZ953425A patent/CZ342595A3/cs unknown
- 1994-06-22 ZA ZA944463A patent/ZA944463B/xx unknown
- 1994-08-02 TW TW083107047A patent/TW418208B/zh active
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1995
- 1995-12-21 FI FI956168A patent/FI956168A/fi not_active IP Right Cessation
- 1995-12-21 NO NO955219A patent/NO955219L/no not_active Application Discontinuation
- 1995-12-27 BG BG100258A patent/BG62933B1/bg unknown
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