ATE86247T1 - 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel. - Google Patents

3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.

Info

Publication number
ATE86247T1
ATE86247T1 AT88904984T AT88904984T ATE86247T1 AT E86247 T1 ATE86247 T1 AT E86247T1 AT 88904984 T AT88904984 T AT 88904984T AT 88904984 T AT88904984 T AT 88904984T AT E86247 T1 ATE86247 T1 AT E86247T1
Authority
AT
Austria
Prior art keywords
pct
acid derivatives
pharmaceuticals
sec
date
Prior art date
Application number
AT88904984T
Other languages
English (en)
Inventor
Luca Giovanna De
Stazio Giovanni Di
Andrea Margonelli
Mario Materazzi
Vincenzo Politi
Original Assignee
Polifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma Spa filed Critical Polifarma Spa
Application granted granted Critical
Publication of ATE86247T1 publication Critical patent/ATE86247T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT88904984T 1987-06-03 1988-06-01 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel. ATE86247T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT8748014A IT1206078B (it) 1987-06-03 1987-06-03 Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
PCT/IT1988/000041 WO1988009789A2 (en) 1987-06-03 1988-06-01 3-indolepyruvic acid derivatives and pharmaceutical use thereof
EP88904984A EP0321516B1 (de) 1987-06-03 1988-06-01 3-indolpyruvsäure-derivate und deren verwendung als arznemittel

Publications (1)

Publication Number Publication Date
ATE86247T1 true ATE86247T1 (de) 1993-03-15

Family

ID=11263959

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88904984T ATE86247T1 (de) 1987-06-03 1988-06-01 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.

Country Status (13)

Country Link
US (1) US5002963A (de)
EP (1) EP0321516B1 (de)
JP (1) JPH02500369A (de)
KR (1) KR960016522B1 (de)
AT (1) ATE86247T1 (de)
AU (1) AU609500B2 (de)
CA (1) CA1328658C (de)
DE (1) DE3878866T2 (de)
DK (1) DK170438B1 (de)
FI (1) FI92055C (de)
IT (1) IT1206078B (de)
NO (1) NO890408L (de)
WO (1) WO1988009789A2 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1224546B (it) * 1988-09-29 1990-10-04 Polifarma Spa Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
PT93943A (pt) * 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE3917880A1 (de) * 1989-06-01 1990-12-06 Kali Chemie Ag Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
IT218019Z2 (it) * 1989-09-08 1992-03-05 Enea Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) * 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5037846A (en) * 1990-01-02 1991-08-06 Pfizer Inc. Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
DK0624569T3 (da) * 1991-02-28 1998-10-26 Merrell Pharma Inc MMDA-antagonister
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
IT1261165B (it) * 1993-01-25 1996-05-09 Polifarma Spa Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
FR2701948B1 (fr) * 1993-02-22 1996-07-26 Exsymol Sa Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) * 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6075150A (en) * 1998-01-26 2000-06-13 Cv Therapeutics, Inc. α-ketoamide inhibitors of 20S proteasome
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6274617B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
BR9815882A (pt) 1998-06-03 2002-09-17 Gpi Nil Holding Inc Sulfonamidas ligadas por n de ácido carboxìlicos n-heterocìclicos ouou de isósteros de ácidos carboxìlicos
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
MXPA02006134A (es) 1999-12-21 2002-12-13 Guilford Pharm Inc Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos.
US6900218B2 (en) 2001-05-03 2005-05-31 Galileo Pharmaceuticals, Inc. Pyruvate derivatives
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
KR100673283B1 (ko) 2001-12-27 2007-01-24 아지노모토 가부시키가이샤 글루탐산 유도체의 제조방법
WO2009028338A1 (ja) 2007-08-24 2009-03-05 Ajinomoto Co., Inc. 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
KR20120068872A (ko) 2010-10-14 2012-06-27 아지노모토 가부시키가이샤 모나틴의 제조 방법
WO2020012373A1 (en) * 2018-07-10 2020-01-16 Polindols S.R.L.S. New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1096881A (en) * 1976-10-07 1981-03-03 Roger R. Gaudette Preparation of aliphatic and heterocyclic alpha-keto carboxylic acids
GR74635B (de) * 1980-08-18 1984-06-29 Merck & Co Inc
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
EP0048159A3 (de) * 1980-09-17 1982-05-12 University Of Miami Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) * 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico

Also Published As

Publication number Publication date
FI92055B (fi) 1994-06-15
NO890408L (no) 1989-03-30
WO1988009789A2 (en) 1988-12-15
KR960016522B1 (ko) 1996-12-14
US5002963A (en) 1991-03-26
IT8748014A0 (it) 1987-06-03
FI890508A0 (fi) 1989-02-02
DK46789A (da) 1989-03-31
DK46789D0 (da) 1989-02-02
DE3878866T2 (de) 1993-09-02
EP0321516A1 (de) 1989-06-28
DK170438B1 (da) 1995-09-04
DE3878866D1 (de) 1993-04-08
JPH02500369A (ja) 1990-02-08
EP0321516B1 (de) 1993-03-03
WO1988009789A3 (en) 1989-02-09
IT1206078B (it) 1989-04-14
KR890701559A (ko) 1989-12-20
AU1943388A (en) 1989-01-04
NO890408D0 (no) 1989-02-01
FI890508L (fi) 1989-02-02
AU609500B2 (en) 1991-05-02
CA1328658C (en) 1994-04-19
FI92055C (fi) 1994-09-26

Similar Documents

Publication Publication Date Title
ATE86247T1 (de) 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.
ATE126232T1 (de) Neue derivate von a-nor-3-carboxysteroiden.
ATE166650T1 (de) Spiroazacyclischderivate als substanz p antagonisten
NO934727L (no) Azanorbornan-derivater
PT641328E (pt) Derivados aza-biciclicos em ponte como antagonistas da substancia p
ATE192045T1 (de) Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose
DE69017606D1 (de) Substituierte Cyclohexanole mit zentraler Nervensystemwirkung.
KR950700296A (ko) 비닐렌-아자인돌 유도체 및 이의 제조방법(Vinylene-Azaindole derivatives and process for their preparation)
MY132875A (en) Pyridazino quinoline compounds
IL81887A0 (en) Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
FI974447A0 (fi) Semikarbatsonit, joilla on keskushermostoaktiivisuutta, ja niitä sisältävät farmaseuttiset valmisteet
MY115211A (en) Novel amino acid derivatives, their preparation and use
ATE95064T1 (de) Verwendung von angiotensin-converting-enzyminhibitoren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit.
DE3852935D1 (de) Substituierte Alpha-Aminosäuren mit pharmazeutischer Aktivität.
FR2594332B1 (fr) Derives d'acides amino-benzoiques, d'acides hydroxy-benzoiques, d'acides cinnamiques, d'acide urocanique et de benzimidazole presentant ou non un groupement d'acide amine absorbant les uvb et/ou les uva et permettant d'eviter les photodermatoses, chez l'homme, consecutives a l'administration de medicaments, a l'emploi de cosmetiques parfumes ou de parfums
ATE157660T1 (de) Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen
ATE71620T1 (de) N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.
DE3751362D1 (de) 5-Aryl-3H-1,2,4-triazol-3-one und ihre Verwendung als Antikonvulsiva.
ATE44961T1 (de) Substituierte o-sulfonyl-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
BG90414A (bg) 2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
DE69206102D1 (de) Di(2-propyl)ester von 1-fluoro-2-phosphonomethoxy-3-p-toluol-sulfonyloxypropan, deren herstellung und vervendung.
ES8604843A1 (es) Un metodo para la preparacion de un derivado de acetileno
ATE229953T1 (de) Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
ATE165344T1 (de) Herstellung von symmetrischen und unsymmetrischen disubstituierten n-cyandithioiminocarbonaten
DE3684825D1 (de) Verwendung von n-(1-allyl-2-pyrrolidinylmethyl)-2-methoxy-4-amino-5-methylsulfamoylbenzamid zur behandlung der parkinson-krankheit.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties