IT1237472B - Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico. - Google Patents

Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.

Info

Publication number
IT1237472B
IT1237472B IT04842689A IT4842689A IT1237472B IT 1237472 B IT1237472 B IT 1237472B IT 04842689 A IT04842689 A IT 04842689A IT 4842689 A IT4842689 A IT 4842689A IT 1237472 B IT1237472 B IT 1237472B
Authority
IT
Italy
Prior art keywords
indolpiruvic
derivatives
acid
production
therapeutic use
Prior art date
Application number
IT04842689A
Other languages
English (en)
Other versions
IT8948426A1 (it
IT8948426A0 (it
Inventor
Vincenzo Politi
Luca Giovanna De
Stazio Giovanni Di
Mario Materazzi
Original Assignee
Polifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma Spa filed Critical Polifarma Spa
Priority to IT04842689A priority Critical patent/IT1237472B/it
Publication of IT8948426A0 publication Critical patent/IT8948426A0/it
Priority to EP90830397A priority patent/EP0421946B1/en
Priority to DE69029186T priority patent/DE69029186T2/de
Priority to US07/584,128 priority patent/US5210215A/en
Publication of IT8948426A1 publication Critical patent/IT8948426A1/it
Application granted granted Critical
Publication of IT1237472B publication Critical patent/IT1237472B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
IT04842689A 1989-10-04 1989-10-04 Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico. IT1237472B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT04842689A IT1237472B (it) 1989-10-04 1989-10-04 Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
EP90830397A EP0421946B1 (en) 1989-10-04 1990-09-07 3-indolepyruvic acid derivatives their method of production and therapeutic use
DE69029186T DE69029186T2 (de) 1989-10-04 1990-09-07 3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung
US07/584,128 US5210215A (en) 1989-10-04 1990-09-18 Tryptophane and 3-indolepyruvic acid, methods of production therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04842689A IT1237472B (it) 1989-10-04 1989-10-04 Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.

Publications (3)

Publication Number Publication Date
IT8948426A0 IT8948426A0 (it) 1989-10-04
IT8948426A1 IT8948426A1 (it) 1991-04-04
IT1237472B true IT1237472B (it) 1993-06-07

Family

ID=11266474

Family Applications (1)

Application Number Title Priority Date Filing Date
IT04842689A IT1237472B (it) 1989-10-04 1989-10-04 Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.

Country Status (4)

Country Link
US (1) US5210215A (it)
EP (1) EP0421946B1 (it)
DE (1) DE69029186T2 (it)
IT (1) IT1237472B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
ES2122098T3 (es) * 1991-02-28 1998-12-16 Merrell Pharma Inc Antagonistas del nmda.
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
CN1079395C (zh) * 1998-03-18 2002-02-20 谭敦宪 N－乙酰－5,6－二甲氧基色胺的生产方法
CA2446136C (en) 2001-05-03 2011-07-05 Galileo Pharmaceuticals, Inc. Pyruvate derivatives
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
KR100775778B1 (ko) 2001-12-27 2007-11-12 아지노모토 가부시키가이샤 글루탐산 유도체의 제조방법
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP2058275A1 (en) 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
CN101415724B (zh) 2003-06-30 2015-12-02 特拉维夫大学未来科技开发有限公司 肽、抗肽抗体以及用它们来诊断和治疗淀粉样蛋白相关疾病的方法
EP1663199B1 (en) 2003-09-25 2013-04-03 Tel Aviv University Future Technology Development L.P. Compositions and methods using same for treating amyloid-associated diseases
WO2005031362A2 (en) 2003-10-02 2005-04-07 Ramot At Tel Aviv University Ltd. Novel antibacterial agents and methods of identifying and utilizing same
WO2005034942A1 (en) 2003-10-03 2005-04-21 Veijlen N.V. Animal feed composition
ATE506948T1 (de) 2003-10-03 2011-05-15 Veijlen N V Verwendung von igf-1-serumspiegel-erhöhenden indolessigsäure-derivaten zur herstellung eines arzneimittels zur behandlung von verschiedenen krankheiten
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
US8568637B2 (en) 2004-08-02 2013-10-29 Ramot At Tel-Aviv University Ltd. Method of forming a fiber made of peptide nanostructures
WO2006018850A2 (en) * 2004-08-19 2006-02-23 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
WO2006027780A2 (en) 2004-09-08 2006-03-16 Ramot At Tel Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US10004828B2 (en) 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
US7879212B2 (en) 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
CN102027117B (zh) 2007-08-24 2012-11-07 味之素株式会社 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
EP2479272A4 (en) 2010-10-14 2013-11-20 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF MONATIN
AR083885A1 (es) 2010-11-15 2013-03-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides
CN108315370A (zh) * 2018-01-19 2018-07-24 滨海吉尔多肽有限公司 一种卤素色氨酸的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2306693A1 (fr) * 1975-04-11 1976-11-05 Roussel Uclaf Nouveaux derives du /9h/pyrido/3,4-b/ indole et leurs sels, procede de preparation et application a titre de medicaments
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
DE3328348A1 (de) * 1983-08-05 1985-02-14 Degussa Ag, 6000 Frankfurt Verfahren zur duennschichtchromatographischen trennung von enantiomeren
IT1184282B (it) * 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico

Also Published As

Publication number Publication date
IT8948426A1 (it) 1991-04-04
US5210215A (en) 1993-05-11
DE69029186D1 (de) 1997-01-02
EP0421946B1 (en) 1996-11-20
EP0421946A3 (en) 1992-01-22
IT8948426A0 (it) 1989-10-04
EP0421946A2 (en) 1991-04-10
DE69029186T2 (de) 1997-03-27

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971021