PT87355A - Process for the production of folinic acid - Google Patents

Process for the production of folinic acid

Info

Publication number
PT87355A
PT87355A PT87355A PT8735588A PT87355A PT 87355 A PT87355 A PT 87355A PT 87355 A PT87355 A PT 87355A PT 8735588 A PT8735588 A PT 8735588A PT 87355 A PT87355 A PT 87355A
Authority
PT
Portugal
Prior art keywords
production
folinic acid
folinic
acid
Prior art date
Application number
PT87355A
Other languages
English (en)
Other versions
PT87355B (pt
Inventor
Hans Rudolf Mueller
Martin Ulmann
Josef Conti
Guenter Muerdel
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4220822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT87355(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eprova Ag filed Critical Eprova Ag
Publication of PT87355A publication Critical patent/PT87355A/pt
Publication of PT87355B publication Critical patent/PT87355B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT87355A 1987-05-15 1988-04-28 Processo para a producao de acido folinico PT87355B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1883/87A CH673459A5 (pt) 1987-05-15 1987-05-15

Publications (2)

Publication Number Publication Date
PT87355A true PT87355A (pt) 1989-06-30
PT87355B PT87355B (pt) 1995-03-01

Family

ID=4220822

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87355A PT87355B (pt) 1987-05-15 1988-04-28 Processo para a producao de acido folinico

Country Status (22)

Country Link
US (3) US5134235A (pt)
EP (2) EP0293029B1 (pt)
JP (1) JPH089618B2 (pt)
KR (1) KR950010074B1 (pt)
CN (1) CN1024553C (pt)
AR (1) AR243890A1 (pt)
AT (1) ATE67498T1 (pt)
AU (1) AU603673B2 (pt)
CA (1) CA1340290C (pt)
CH (1) CH673459A5 (pt)
DD (1) DD270073A5 (pt)
DE (1) DE3864904D1 (pt)
DK (1) DK173708B1 (pt)
ES (1) ES2040321T3 (pt)
FI (1) FI93729C (pt)
GR (1) GR3002756T3 (pt)
HU (1) HU201072B (pt)
IE (1) IE60839B1 (pt)
NZ (1) NZ224361A (pt)
PT (1) PT87355B (pt)
WO (1) WO1988008844A1 (pt)
ZA (1) ZA883344B (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (pt) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (pt) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (pt) * 1988-11-11 1991-03-28 Eprova Ag
CA2021042A1 (en) * 1989-07-21 1991-01-22 Fabrizio Marazza Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
CH680731A5 (pt) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (pt) * 1991-01-16 1993-02-26 Eprova Ag
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
US5660835A (en) 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
CN1311665A (zh) * 1998-08-03 2001-09-05 新生制药公司 一种新的止痛、抗炎和创伤治疗剂
WO2002085296A2 (en) * 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
AU2002303427A1 (en) * 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
GB0206711D0 (en) 2002-03-21 2002-05-01 Isis Innovation HIF Inhibitor
US7405207B2 (en) * 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
AU2003269889B2 (en) * 2002-06-17 2007-04-19 Epigenesis Pharmaceuticals, Llc Dihydrate dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026848A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CH696699A5 (de) * 2006-01-19 2007-10-15 Cerbios Pharma Sa Verfahren zur regioselektiven N(5) -Formylierung von (6S) -5, 6, 7, 8-Tetrahydropteroinsäure und Derivaten davon.
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
CN101792444B (zh) * 2009-02-02 2011-10-12 天津康鸿医药科技发展有限公司 左亚叶酸钠及其制备方法及药物组合物
CN101863889B (zh) * 2009-04-20 2013-07-03 重庆华邦胜凯制药有限公司 左亚叶酸钙的纯化方法
CN102101862B (zh) * 2009-12-21 2013-01-09 天津康鸿医药科技发展有限公司 一种制备左亚叶酸钠或混旋亚叶酸钠的方法
EP2502625A1 (en) 2011-03-21 2012-09-26 GMT Fine Chemicals SA Process for the preparation of crystalline levofolinic acid
US9713616B2 (en) 2012-08-06 2017-07-25 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising L-leucovorin
US9629846B1 (en) 2013-11-14 2017-04-25 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US9492421B1 (en) 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
CN105367574A (zh) * 2015-10-27 2016-03-02 浙江大为药业有限公司 一种高纯度左旋亚叶酸钙的制备工艺
CN111138434A (zh) * 2019-09-18 2020-05-12 南京海纳医药科技股份有限公司 一种左亚叶酸的制备方法
CN112649524B (zh) * 2020-12-02 2022-05-17 重庆华邦胜凯制药有限公司 分离检测叶酸中叶酸及叶酸光学异构体的方法

Family Cites Families (9)

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US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (pt) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (pt) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (pt) * 1988-11-11 1991-03-28 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.

Also Published As

Publication number Publication date
CN1024553C (zh) 1994-05-18
DK254688A (da) 1988-11-16
ZA883344B (en) 1988-11-09
IE60839B1 (en) 1994-08-24
FI93729B (fi) 1995-02-15
ES2040321T3 (es) 1993-10-16
GR3002756T3 (en) 1993-01-25
ATE67498T1 (de) 1991-10-15
KR890700590A (ko) 1989-04-26
KR950010074B1 (en) 1995-09-06
DK173708B1 (da) 2001-07-09
PT87355B (pt) 1995-03-01
FI890195A0 (fi) 1989-01-13
AU1703188A (en) 1988-12-06
WO1988008844A1 (en) 1988-11-17
DE3864904D1 (de) 1991-10-24
CA1340290C (en) 1998-12-29
US5134235A (en) 1992-07-28
US5347005A (en) 1994-09-13
CH673459A5 (pt) 1990-03-15
EP0293029A1 (de) 1988-11-30
JPH01503787A (ja) 1989-12-21
HUT49880A (en) 1989-11-28
NZ224361A (en) 1989-10-27
AU603673B2 (en) 1990-11-22
AR243890A1 (es) 1993-09-30
FI93729C (fi) 1995-05-26
FI890195A (fi) 1989-01-13
EP0293029B1 (de) 1991-09-18
US6160116A (en) 2000-12-12
DD270073A5 (de) 1989-07-19
CN88102709A (zh) 1988-12-28
EP0314720A1 (de) 1989-05-10
IE881450L (en) 1988-11-15
HU201072B (en) 1990-09-28
DK254688D0 (da) 1988-05-09
JPH089618B2 (ja) 1996-01-31

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Legal Events

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FG3A Patent granted, date of granting

Effective date: 19940812

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090812

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090812