KR890700590A - 폴린산의 분리방법 - Google Patents

폴린산의 분리방법

Info

Publication number
KR890700590A
KR890700590A KR1019880701643A KR880701643A KR890700590A KR 890700590 A KR890700590 A KR 890700590A KR 1019880701643 A KR1019880701643 A KR 1019880701643A KR 880701643 A KR880701643 A KR 880701643A KR 890700590 A KR890700590 A KR 890700590A
Authority
KR
South Korea
Prior art keywords
folic acid
salts
separate
alkali
salt
Prior art date
Application number
KR1019880701643A
Other languages
English (en)
Other versions
KR950010074B1 (en
Inventor
루돌프 뮤엘러 한스
울만 마틴
콘티 오셉
뮤어델 귄터
Original Assignee
에이치.알.뮬러, 에이치.주터
에프로바 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4220822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890700590(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 에이치.알.뮬러, 에이치.주터, 에프로바 아크티엔게젤샤프트 filed Critical 에이치.알.뮬러, 에이치.주터
Publication of KR890700590A publication Critical patent/KR890700590A/ko
Application granted granted Critical
Publication of KR950010074B1 publication Critical patent/KR950010074B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

폴린산의 분리방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. (6R, S) -폴린산의 알카리 -금속염을 제결정화하고, 필요시, 알카리 -토폴리네이트로부터 산을 분리하고/하거나. 필요시 알카리 염으로 전환시켜 (6S)-폴린산 및 그의 염을 제조하는 방법에 있어서, 재결정화를 염기 존재하에 수행함을 특징으로 하는 (6S)-폴린산 및 그의 염의 제조방법.
  2. 제1항에 있어서, 수득한 결정성 생성물을 염기 존재하에 또는 대략 중성의 pH에서 1회이상 추가로 재결정화시킴을 특징으로 하는 (6S)-폴린산 및 그의 염의 제조방법.
  3. 제1항 및 제2항에 있어서, 재결정화를 추가의 알카리-토금속 이온 존재하에 수행함을 특징으로 하는 (6S)-폴린산 및 그의 염의 제조방법.
  4. 제1항 또는 제2항에 따라 제조된 (6S)-폴린산 및 그의 칼슘염.
  5. (6S)-폴린산의 마그네슝 염.
  6. (6S)-폴린산의 나트륨 및 칼륨 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR88701643A 1987-05-15 1988-12-10 Process for separating folinic acid KR950010074B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH01883/87-0 1987-05-15
CH1883/87A CH673459A5 (ko) 1987-05-15 1987-05-15
PCT/EP1988/000341 WO1988008844A1 (en) 1987-05-15 1988-04-22 Process for separation of folinic acids

Publications (2)

Publication Number Publication Date
KR890700590A true KR890700590A (ko) 1989-04-26
KR950010074B1 KR950010074B1 (en) 1995-09-06

Family

ID=4220822

Family Applications (1)

Application Number Title Priority Date Filing Date
KR88701643A KR950010074B1 (en) 1987-05-15 1988-12-10 Process for separating folinic acid

Country Status (22)

Country Link
US (3) US5134235A (ko)
EP (2) EP0293029B1 (ko)
JP (1) JPH089618B2 (ko)
KR (1) KR950010074B1 (ko)
CN (1) CN1024553C (ko)
AR (1) AR243890A1 (ko)
AT (1) ATE67498T1 (ko)
AU (1) AU603673B2 (ko)
CA (1) CA1340290C (ko)
CH (1) CH673459A5 (ko)
DD (1) DD270073A5 (ko)
DE (1) DE3864904D1 (ko)
DK (1) DK173708B1 (ko)
ES (1) ES2040321T3 (ko)
FI (1) FI93729C (ko)
GR (1) GR3002756T3 (ko)
HU (1) HU201072B (ko)
IE (1) IE60839B1 (ko)
NZ (1) NZ224361A (ko)
PT (1) PT87355B (ko)
WO (1) WO1988008844A1 (ko)
ZA (1) ZA883344B (ko)

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CN101863889B (zh) * 2009-04-20 2013-07-03 重庆华邦胜凯制药有限公司 左亚叶酸钙的纯化方法
CN102101862B (zh) * 2009-12-21 2013-01-09 天津康鸿医药科技发展有限公司 一种制备左亚叶酸钠或混旋亚叶酸钠的方法
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Also Published As

Publication number Publication date
HUT49880A (en) 1989-11-28
DD270073A5 (de) 1989-07-19
CH673459A5 (ko) 1990-03-15
AU603673B2 (en) 1990-11-22
JPH01503787A (ja) 1989-12-21
US5347005A (en) 1994-09-13
DK173708B1 (da) 2001-07-09
US5134235A (en) 1992-07-28
CA1340290C (en) 1998-12-29
US6160116A (en) 2000-12-12
WO1988008844A1 (en) 1988-11-17
EP0314720A1 (de) 1989-05-10
IE881450L (en) 1988-11-15
FI890195A0 (fi) 1989-01-13
PT87355B (pt) 1995-03-01
EP0293029A1 (de) 1988-11-30
FI890195A (fi) 1989-01-13
ATE67498T1 (de) 1991-10-15
PT87355A (pt) 1989-06-30
FI93729B (fi) 1995-02-15
IE60839B1 (en) 1994-08-24
GR3002756T3 (en) 1993-01-25
HU201072B (en) 1990-09-28
CN1024553C (zh) 1994-05-18
FI93729C (fi) 1995-05-26
AR243890A1 (es) 1993-09-30
AU1703188A (en) 1988-12-06
ES2040321T3 (es) 1993-10-16
NZ224361A (en) 1989-10-27
DE3864904D1 (de) 1991-10-24
DK254688A (da) 1988-11-16
ZA883344B (en) 1988-11-09
EP0293029B1 (de) 1991-09-18
KR950010074B1 (en) 1995-09-06
DK254688D0 (da) 1988-05-09
JPH089618B2 (ja) 1996-01-31
CN88102709A (zh) 1988-12-28

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