IT1254635B - Processo per la separazione degli stereoisomeri dell'acido folinico - Google Patents

Processo per la separazione degli stereoisomeri dell'acido folinico

Info

Publication number
IT1254635B
IT1254635B ITMI920367A ITMI920367A IT1254635B IT 1254635 B IT1254635 B IT 1254635B IT MI920367 A ITMI920367 A IT MI920367A IT MI920367 A ITMI920367 A IT MI920367A IT 1254635 B IT1254635 B IT 1254635B
Authority
IT
Italy
Prior art keywords
separation
folinic acid
acid stereoisomers
stereoisomers
folinic
Prior art date
Application number
ITMI920367A
Other languages
English (en)
Inventor
Giorgio Ripa
Rodolfo Piva
Ernst Felder
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of ITMI920367A0 publication Critical patent/ITMI920367A0/it
Priority to ITMI920367A priority Critical patent/IT1254635B/it
Priority to KR1019940702846A priority patent/KR100256929B1/ko
Priority to ES93903973T priority patent/ES2065299T1/es
Priority to JP51450793A priority patent/JP3162073B2/ja
Priority to PCT/EP1993/000361 priority patent/WO1993017022A1/en
Priority to DE69319420T priority patent/DE69319420T2/de
Priority to DE0626965T priority patent/DE626965T1/de
Priority to EP93903973A priority patent/EP0626965B1/en
Priority to AT93903973T priority patent/ATE167864T1/de
Publication of ITMI920367A1 publication Critical patent/ITMI920367A1/it
Priority to GR940300096T priority patent/GR940300096T1/el
Priority to US08/456,767 priority patent/US5599931A/en
Application granted granted Critical
Publication of IT1254635B publication Critical patent/IT1254635B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

L'acido (6R, S) folinico viene risolto nei suoi isomeri (6R) e (6S) per salificazione come amine almeno dibasiche e precipitazione di miscele dei sali ottenuti arricchite nella forma (6R) o (6S).
ITMI920367A 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico IT1254635B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI920367A IT1254635B (it) 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico
DE0626965T DE626965T1 (de) 1992-02-20 1993-02-16 Verfahren zur Trennung von Stereoisomere von Fölinsäure.
ES93903973T ES2065299T1 (es) 1992-02-20 1993-02-16 Procedimiento para la separacion de estereoisomeros del acido folinico.
JP51450793A JP3162073B2 (ja) 1992-02-20 1993-02-16 ホリニン酸の立体異性体を分離する方法
PCT/EP1993/000361 WO1993017022A1 (en) 1992-02-20 1993-02-16 Process for separating stereoisomers of folinic acid
DE69319420T DE69319420T2 (de) 1992-02-20 1993-02-16 Verfahren zur trennung von stereoisomere von folinsäure
KR1019940702846A KR100256929B1 (ko) 1992-02-20 1993-02-16 폴린산의 입체 이성질체 분리 방법
EP93903973A EP0626965B1 (en) 1992-02-20 1993-02-16 Process for separating stereoisomers of folinic acid
AT93903973T ATE167864T1 (de) 1992-02-20 1993-02-16 Verfahren zur trennung von stereoisomere von folinsäure
GR940300096T GR940300096T1 (en) 1992-02-20 1995-01-31 Process for separating stereoisomers of folinic acid.
US08/456,767 US5599931A (en) 1992-02-20 1995-06-01 Process for separating stereoisomers of folinic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920367A IT1254635B (it) 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico

Publications (3)

Publication Number Publication Date
ITMI920367A0 ITMI920367A0 (it) 1992-02-20
ITMI920367A1 ITMI920367A1 (it) 1993-08-20
IT1254635B true IT1254635B (it) 1995-09-28

Family

ID=11362053

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920367A IT1254635B (it) 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico

Country Status (9)

Country Link
EP (1) EP0626965B1 (it)
JP (1) JP3162073B2 (it)
KR (1) KR100256929B1 (it)
AT (1) ATE167864T1 (it)
DE (2) DE69319420T2 (it)
ES (1) ES2065299T1 (it)
GR (1) GR940300096T1 (it)
IT (1) IT1254635B (it)
WO (1) WO1993017022A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
EP2502625A1 (en) * 2011-03-21 2012-09-26 GMT Fine Chemicals SA Process for the preparation of crystalline levofolinic acid
EP3461826A1 (en) 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts
EP3646873A1 (en) * 2018-10-31 2020-05-06 Aprofol AG Folate salts
KR102339433B1 (ko) * 2018-11-29 2021-12-15 주식회사 경보제약 고순도 팔로노세트론 중간체 제조 방법
CN113666931B (zh) * 2021-09-07 2023-11-03 浙江大为药业有限公司 一种高纯左亚叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (it) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (it) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (it) * 1988-11-11 1991-03-28 Eprova Ag
EP0432441B1 (en) * 1989-12-11 1996-06-26 American Cyanamid Company Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (it) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (it) * 1991-01-16 1993-02-26 Eprova Ag

Also Published As

Publication number Publication date
DE69319420T2 (de) 1998-11-05
WO1993017022A1 (en) 1993-09-02
ES2065299T1 (es) 1995-02-16
JP3162073B2 (ja) 2001-04-25
ITMI920367A1 (it) 1993-08-20
DE626965T1 (de) 1995-07-06
EP0626965A1 (en) 1994-12-07
ATE167864T1 (de) 1998-07-15
EP0626965B1 (en) 1998-07-01
GR940300096T1 (en) 1995-01-31
KR100256929B1 (ko) 2000-05-15
DE69319420D1 (de) 1998-08-06
KR950700300A (ko) 1995-01-16
ITMI920367A0 (it) 1992-02-20
JPH07506813A (ja) 1995-07-27

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