ATE283864T1 - Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor - Google Patents
Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktorInfo
- Publication number
- ATE283864T1 ATE283864T1 AT92914056T AT92914056T ATE283864T1 AT E283864 T1 ATE283864 T1 AT E283864T1 AT 92914056 T AT92914056 T AT 92914056T AT 92914056 T AT92914056 T AT 92914056T AT E283864 T1 ATE283864 T1 AT E283864T1
- Authority
- AT
- Austria
- Prior art keywords
- fragment
- aqueous solution
- von willebrand
- willebrand factor
- denaturant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71794291A | 1991-06-20 | 1991-06-20 | |
PCT/US1992/005215 WO1993000107A1 (en) | 1991-06-20 | 1992-06-19 | Therapeutic fragments of von willebrand factor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE283864T1 true ATE283864T1 (de) | 2004-12-15 |
Family
ID=24884150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92914056T ATE283864T1 (de) | 1991-06-20 | 1992-06-19 | Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor |
Country Status (9)
Country | Link |
---|---|
US (1) | US5539086A (de) |
EP (1) | EP0590048B1 (de) |
AT (1) | ATE283864T1 (de) |
AU (1) | AU2253392A (de) |
CA (1) | CA2110585C (de) |
DE (1) | DE69233451T2 (de) |
ES (1) | ES2233924T3 (de) |
MX (1) | MX9203011A (de) |
WO (1) | WO1993000107A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
US5849536A (en) * | 1990-03-02 | 1998-12-15 | Bio-Technology General Corp. | Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same |
US5847086A (en) * | 1991-06-20 | 1998-12-08 | Centeon L.L.C. | Therapeutic fragments of von Willebrand factor |
US6821943B2 (en) | 2001-03-13 | 2004-11-23 | S. C. Johnson & Son, Inc. | Hard surface antimicrobial cleaner with residual antimicrobial effect comprising an organosilane |
AU2003223936A1 (en) * | 2002-05-17 | 2003-12-02 | Kobenhavns Universitet | Method for purifying denatured proteins having a desired disulfide bond configuration |
CA2579374A1 (en) | 2004-09-07 | 2006-03-30 | Archemix Corp. | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
WO2006029258A2 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
AU2014202595A1 (en) * | 2007-12-28 | 2014-06-05 | Baxalta GmbH | Recombinant VWF Formulations |
NZ586383A (en) * | 2007-12-28 | 2012-11-30 | Baxter Int | Recombinant vwf formulations |
US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
EP2601932A1 (de) * | 2008-10-21 | 2013-06-12 | Baxter International Inc. | Lyophilisierte rekombinante VWF-Formulierungen |
US8759293B2 (en) * | 2009-11-13 | 2014-06-24 | Grifols Therapeutics Inc. | von Willebrand factor (vWF)-containing preparations, and methods, kits, and uses related thereto |
AU2016204172A1 (en) * | 2016-06-20 | 2018-01-18 | The University Of Sydney | Allosteric regulation of haemostatic activity |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
DE3751179T2 (de) * | 1986-05-30 | 1995-07-27 | Scripps Research Inst | Peptide, die die Bindung des Von-Willebrand-Faktors inhibieren. |
US5043429B1 (en) * | 1987-05-01 | 1997-10-14 | Scripps Research Inst | Protein fragments containing factor VIII binding domain of von willebrand factor |
US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
US5530100A (en) * | 1990-05-07 | 1996-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods for purification of recombinantly produced proteins |
-
1992
- 1992-06-19 DE DE69233451T patent/DE69233451T2/de not_active Expired - Lifetime
- 1992-06-19 EP EP92914056A patent/EP0590048B1/de not_active Expired - Lifetime
- 1992-06-19 AT AT92914056T patent/ATE283864T1/de active
- 1992-06-19 CA CA002110585A patent/CA2110585C/en not_active Expired - Lifetime
- 1992-06-19 WO PCT/US1992/005215 patent/WO1993000107A1/en active IP Right Grant
- 1992-06-19 AU AU22533/92A patent/AU2253392A/en not_active Abandoned
- 1992-06-19 ES ES92914056T patent/ES2233924T3/es not_active Expired - Lifetime
- 1992-06-19 MX MX9203011A patent/MX9203011A/es active IP Right Grant
-
1994
- 1994-02-18 US US08/198,849 patent/US5539086A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2233924T3 (es) | 2005-06-16 |
MX9203011A (es) | 1993-08-01 |
AU2253392A (en) | 1993-01-25 |
US5539086A (en) | 1996-07-23 |
DE69233451T2 (de) | 2006-01-12 |
EP0590048B1 (de) | 2004-12-01 |
EP0590048A4 (en) | 1994-06-08 |
CA2110585C (en) | 2004-10-12 |
DE69233451D1 (de) | 2005-01-05 |
EP0590048A1 (de) | 1994-04-06 |
CA2110585A1 (en) | 1993-01-07 |
WO1993000107A1 (en) | 1993-01-07 |
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Legal Events
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