DE3680800D1 - Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin. - Google Patents

Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin.

Info

Publication number
DE3680800D1
DE3680800D1 DE8686100944T DE3680800T DE3680800D1 DE 3680800 D1 DE3680800 D1 DE 3680800D1 DE 8686100944 T DE8686100944 T DE 8686100944T DE 3680800 T DE3680800 T DE 3680800T DE 3680800 D1 DE3680800 D1 DE 3680800D1
Authority
DE
Germany
Prior art keywords
biopterin
tetrahydro
amine
acyl groups
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686100944T
Other languages
English (en)
Inventor
Hideaki Sakai
Tadashi Kanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiratori Pharmaceutical Co Ltd
Asubio Pharma Co Ltd
Original Assignee
SHIRATORI PHARMACEUTICAL CO Ltd NARASHINO CHIBA JP
Shiratori Pharmaceutical Co Ltd
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26348109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3680800(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60012477A external-priority patent/JPS61172876A/ja
Priority claimed from JP60012478A external-priority patent/JPS61172877A/ja
Application filed by SHIRATORI PHARMACEUTICAL CO Ltd NARASHINO CHIBA JP, Shiratori Pharmaceutical Co Ltd, Suntory Ltd filed Critical SHIRATORI PHARMACEUTICAL CO Ltd NARASHINO CHIBA JP
Application granted granted Critical
Publication of DE3680800D1 publication Critical patent/DE3680800D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
DE8686100944T 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin. Expired - Lifetime DE3680800D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60012477A JPS61172876A (ja) 1985-01-28 1985-01-28 （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
JP60012478A JPS61172877A (ja) 1985-01-28 1985-01-28 （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法

Publications (1)

Publication Number Publication Date
DE3680800D1 true DE3680800D1 (de) 1991-09-19

Family

ID=26348109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686100944T Expired - Lifetime DE3680800D1 (de) 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin.

Country Status (6)

Country Link
US (1) US4713454A (de)
EP (1) EP0191335B1 (de)
AT (1) ATE66229T1 (de)
AU (1) AU581052B2 (de)
CA (1) CA1262347A (de)
DE (1) DE3680800D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
EP0318926B1 (de) * 1987-11-30 1995-05-03 Kabushiki Kaisha Vitamin Kenkyusyo Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
WO2005065018A2 (en) 2003-11-17 2005-07-21 Merck Eprova Ag Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride
DK1708690T3 (en) * 2003-11-17 2016-11-07 Biomarin Pharm Inc TREATMENT OF PHENYLKETONURI WITH BH4
AU2012200512C1 (en) * 2003-11-17 2020-04-30 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
KR20070084270A (ko) 2004-11-17 2007-08-24 바이오마린 파머수티컬 인크. 안정한 정제 제형물
WO2006063215A2 (en) * 2004-12-08 2006-06-15 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
EP1869048B8 (de) * 2005-04-14 2009-04-15 Shiratori Pharmaceutical Co., Ltd. Verfahren zur herstellung von alphaformkristallen von sapropterinhydrochlorid
EP1965803A1 (de) * 2005-12-05 2008-09-10 Biomarin Pharmaceutical Inc. Verfahren und zusammensetzungen zur behandlung von krankheiten
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
CA2675134A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Pterin analogs
PT2545939T (pt) 2007-04-11 2021-02-17 Biomarin Pharm Inc Métodos de administração de tetra-hidrobiopterina, composições associadas, e métodos de medição
ES2524026T3 (es) * 2008-01-03 2014-12-03 Biomarin Pharmaceutical Inc. Análogo de pterina para tratar una afección que responde a BH4
TW200942542A (en) * 2008-01-07 2009-10-16 Biomarin Pharm Inc Method of synthesizing tetrahydrobiopterin
IT1400964B1 (it) 2010-06-15 2013-07-05 Dipharma Francis Srl Procedimento per la preparazione di derivati pteridinici
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
CA2827679C (en) 2011-02-18 2020-06-02 Alexion Pharma International Sarl Methods for synthesizing molybdopterin precursor z derivatives
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
ES2681345T3 (es) 2012-05-07 2018-09-12 Shiratori Pharmaceutical Co., Ltd. Método para producir sepiapterina y tetrahidrolactoilpterina
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
EP3415499B1 (de) * 2016-02-10 2020-05-13 Sumitomo Chemical Company, Limited Verfahren zur herstellung von 1-methylpyrrolidin-3-ol
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

Also Published As

Publication number Publication date
EP0191335B1 (de) 1991-08-14
CA1262347A (en) 1989-10-17
ATE66229T1 (de) 1991-08-15
AU5272086A (en) 1986-07-31
EP0191335A3 (en) 1988-02-10
US4713454A (en) 1987-12-15
EP0191335A2 (de) 1986-08-20
AU581052B2 (en) 1989-02-09

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: SHIRATORI PHARMACEUTICAL CO. LTD., NARASHINO, CHIB

Owner name: DAIICHI SUNTORY PHARMA CO., LTD., TOKIO/TOKYO, JP

8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI ASUBIO PHARMA CO., LTD., TOKIO/TOKYO, JP

Owner name: SHIRATORI PHARMACEUTICAL CO. LTD., NARASHINO, CHIB