ATE66229T1 - Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. - Google Patents

Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Info

Publication number
ATE66229T1
ATE66229T1 AT86100944T AT86100944T ATE66229T1 AT E66229 T1 ATE66229 T1 AT E66229T1 AT 86100944 T AT86100944 T AT 86100944T AT 86100944 T AT86100944 T AT 86100944T AT E66229 T1 ATE66229 T1 AT E66229T1
Authority
AT
Austria
Prior art keywords
biopterin
tetrahydro
amine
acyl groups
production
Prior art date
Application number
AT86100944T
Other languages
English (en)
Inventor
Hideaki Sakai
Tadashi Kanai
Original Assignee
Shiratori Pharm
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26348109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE66229(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60012478A external-priority patent/JPS61172877A/ja
Priority claimed from JP60012477A external-priority patent/JPS61172876A/ja
Application filed by Shiratori Pharm, Suntory Ltd filed Critical Shiratori Pharm
Application granted granted Critical
Publication of ATE66229T1 publication Critical patent/ATE66229T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT86100944T 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. ATE66229T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP60012478A JPS61172877A (ja) 1985-01-28 1985-01-28 （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法
JP60012477A JPS61172876A (ja) 1985-01-28 1985-01-28 （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
EP86100944A EP0191335B1 (de) 1985-01-28 1986-01-24 Verfahren zur Herstellung von (6R)-Tetrahydro-L-biopterin

Publications (1)

Publication Number Publication Date
ATE66229T1 true ATE66229T1 (de) 1991-08-15

Family

ID=26348109

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86100944T ATE66229T1 (de) 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Country Status (6)

Country Link
US (1) US4713454A (de)
EP (1) EP0191335B1 (de)
AT (1) ATE66229T1 (de)
AU (1) AU581052B2 (de)
CA (1) CA1262347A (de)
DE (1) DE3680800D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
EP0318926B1 (de) * 1987-11-30 1995-05-03 Kabushiki Kaisha Vitamin Kenkyusyo Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
PL1708690T3 (pl) * 2003-11-17 2017-01-31 Biomarin Pharmaceutical Inc. Leczenie fenyloketonurii za pomocą BH4
AU2012200512C1 (en) * 2003-11-17 2020-04-30 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
CA2678125C (en) 2003-11-17 2014-10-14 Merck Eprova Ag Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride
WO2006055511A2 (en) 2004-11-17 2006-05-26 Biomarin Pharmaceutical Inc. Stable tablet formulation of tetrahydrobiopterin
JP2008523090A (ja) * 2004-12-08 2008-07-03 バイオマリン ファーマシューティカル インコーポレイテッド 新生児肺高血圧症の治療のための方法および組成物
PT1869048E (pt) * 2005-04-14 2009-03-05 Asubio Pharma Co Ltd Método de produção de cristais de cloridrato de sapropterina na forma alfa
AU2006321942A1 (en) * 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
HRP20220188T3 (hr) 2007-04-11 2022-04-29 Biomarin Pharmaceutical Inc. Načini primjene tetrahidrobiopterina, povezani pripravci i postupci mjerenja
ES2524026T3 (es) * 2008-01-03 2014-12-03 Biomarin Pharmaceutical Inc. Análogo de pterina para tratar una afección que responde a BH4
CA2711444C (en) * 2008-01-07 2017-12-12 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
IT1400964B1 (it) 2010-06-15 2013-07-05 Dipharma Francis Srl Procedimento per la preparazione di derivati pteridinici
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
US9260462B2 (en) 2011-02-18 2016-02-16 Alexion Pharmaceuticals, Inc. Methods for synthesizing molybdopterin precursor Z derivatives
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
CN102627644B (zh) 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
US9181254B2 (en) 2012-05-07 2015-11-10 Shiratori Pharmaceutical Co., Ltd. Method for producing sepiapterin and tetrahydrolactoylpterin
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
JP6770005B2 (ja) * 2016-02-10 2020-10-14 住友化学株式会社 １−メチルピロリジン−３−オールの製造方法
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

Also Published As

Publication number Publication date
US4713454A (en) 1987-12-15
CA1262347A (en) 1989-10-17
AU5272086A (en) 1986-07-31
EP0191335A3 (en) 1988-02-10
AU581052B2 (en) 1989-02-09
EP0191335A2 (de) 1986-08-20
EP0191335B1 (de) 1991-08-14
DE3680800D1 (de) 1991-09-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time