DE69319420T2 - Verfahren zur trennung von stereoisomere von folinsäure - Google Patents

Verfahren zur trennung von stereoisomere von folinsäure

Info

Publication number
DE69319420T2
DE69319420T2 DE69319420T DE69319420T DE69319420T2 DE 69319420 T2 DE69319420 T2 DE 69319420T2 DE 69319420 T DE69319420 T DE 69319420T DE 69319420 T DE69319420 T DE 69319420T DE 69319420 T2 DE69319420 T2 DE 69319420T2
Authority
DE
Germany
Prior art keywords
folic acid
separating stereoisomers
folinic acid
stereoisomers
separating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69319420T
Other languages
English (en)
Other versions
DE69319420D1 (de
Inventor
Giorgio Ripa
Rodolfo Piva
Ernst Felder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of DE69319420D1 publication Critical patent/DE69319420D1/de
Application granted granted Critical
Publication of DE69319420T2 publication Critical patent/DE69319420T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE69319420T 1992-02-20 1993-02-16 Verfahren zur trennung von stereoisomere von folinsäure Expired - Lifetime DE69319420T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920367A IT1254635B (it) 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico
PCT/EP1993/000361 WO1993017022A1 (en) 1992-02-20 1993-02-16 Process for separating stereoisomers of folinic acid

Publications (2)

Publication Number Publication Date
DE69319420D1 DE69319420D1 (de) 1998-08-06
DE69319420T2 true DE69319420T2 (de) 1998-11-05

Family

ID=11362053

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69319420T Expired - Lifetime DE69319420T2 (de) 1992-02-20 1993-02-16 Verfahren zur trennung von stereoisomere von folinsäure
DE0626965T Pending DE626965T1 (de) 1992-02-20 1993-02-16 Verfahren zur Trennung von Stereoisomere von Fölinsäure.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE0626965T Pending DE626965T1 (de) 1992-02-20 1993-02-16 Verfahren zur Trennung von Stereoisomere von Fölinsäure.

Country Status (9)

Country Link
EP (1) EP0626965B1 (de)
JP (1) JP3162073B2 (de)
KR (1) KR100256929B1 (de)
AT (1) ATE167864T1 (de)
DE (2) DE69319420T2 (de)
ES (1) ES2065299T1 (de)
GR (1) GR940300096T1 (de)
IT (1) IT1254635B (de)
WO (1) WO1993017022A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
EP2502625A1 (de) * 2011-03-21 2012-09-26 GMT Fine Chemicals SA Verfahren zur Herstellung von kristalliner Levofolinsäure
EP3461826A1 (de) * 2017-09-29 2019-04-03 Aprofol AG Multifunktionelle folatsalze
EP3646873A1 (de) 2018-10-31 2020-05-06 Aprofol AG Folatsalze
KR102339433B1 (ko) * 2018-11-29 2021-12-15 주식회사 경보제약 고순도 팔로노세트론 중간체 제조 방법
CN113666931B (zh) * 2021-09-07 2023-11-03 浙江大为药业有限公司 一种高纯左亚叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (de) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (de) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (de) * 1988-11-11 1991-03-28 Eprova Ag
EP0432441B1 (de) * 1989-12-11 1996-06-26 American Cyanamid Company Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (de) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (de) * 1991-01-16 1993-02-26 Eprova Ag

Also Published As

Publication number Publication date
ES2065299T1 (es) 1995-02-16
ITMI920367A1 (it) 1993-08-20
EP0626965A1 (de) 1994-12-07
ATE167864T1 (de) 1998-07-15
IT1254635B (it) 1995-09-28
ITMI920367A0 (it) 1992-02-20
JP3162073B2 (ja) 2001-04-25
WO1993017022A1 (en) 1993-09-02
KR950700300A (ko) 1995-01-16
DE626965T1 (de) 1995-07-06
EP0626965B1 (de) 1998-07-01
DE69319420D1 (de) 1998-08-06
JPH07506813A (ja) 1995-07-27
KR100256929B1 (ko) 2000-05-15
GR940300096T1 (en) 1995-01-31

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