ES2065299T1 - Procedimiento para la separacion de estereoisomeros del acido folinico. - Google Patents
Procedimiento para la separacion de estereoisomeros del acido folinico.Info
- Publication number
- ES2065299T1 ES2065299T1 ES93903973T ES93903973T ES2065299T1 ES 2065299 T1 ES2065299 T1 ES 2065299T1 ES 93903973 T ES93903973 T ES 93903973T ES 93903973 T ES93903973 T ES 93903973T ES 2065299 T1 ES2065299 T1 ES 2065299T1
- Authority
- ES
- Spain
- Prior art keywords
- folinic acid
- stereoisomers
- separation
- procedure
- folinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title abstract 3
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 title abstract 3
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title abstract 3
- 235000008191 folinic acid Nutrition 0.000 title abstract 3
- 239000011672 folinic acid Substances 0.000 title abstract 3
- 229960001691 leucovorin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
EL ESTEREOISOMERO (6S) DE ACIDO FOLINICO SE CONTIENE DE MODO QUE TENGA UNA GRAN PUREZA OPTICA MEDIANTE LA SALIFICACION DE ACIDO FOLINICO (R, S) CON DIACION SELECTIVA POSTERIOR DE LA SAL DIASTOMERICA DESEADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920367A IT1254635B (it) | 1992-02-20 | 1992-02-20 | Processo per la separazione degli stereoisomeri dell'acido folinico |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2065299T1 true ES2065299T1 (es) | 1995-02-16 |
Family
ID=11362053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93903973T Pending ES2065299T1 (es) | 1992-02-20 | 1993-02-16 | Procedimiento para la separacion de estereoisomeros del acido folinico. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0626965B1 (es) |
JP (1) | JP3162073B2 (es) |
KR (1) | KR100256929B1 (es) |
AT (1) | ATE167864T1 (es) |
DE (2) | DE626965T1 (es) |
ES (1) | ES2065299T1 (es) |
GR (1) | GR940300096T1 (es) |
IT (1) | IT1254635B (es) |
WO (1) | WO1993017022A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599931A (en) * | 1992-02-20 | 1997-02-04 | Bracco S.P.A. | Process for separating stereoisomers of folinic acid |
IT1270185B (it) * | 1994-06-08 | 1997-04-29 | Bracco Spa | Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico |
US5710271A (en) * | 1994-06-08 | 1998-01-20 | Dibra S.P.A. | Process for the preparation and separation of diastereomeric salts of folinic acid |
CH696717A5 (de) * | 2004-02-20 | 2007-10-31 | Cerbios Pharma Sa | Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt |
EP2502625A1 (en) * | 2011-03-21 | 2012-09-26 | GMT Fine Chemicals SA | Process for the preparation of crystalline levofolinic acid |
EP3461826A1 (en) | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
EP3646873A1 (en) | 2018-10-31 | 2020-05-06 | Aprofol AG | Folate salts |
KR102339433B1 (ko) * | 2018-11-29 | 2021-12-15 | 주식회사 경보제약 | 고순도 팔로노세트론 중간체 제조 방법 |
CN113666931B (zh) * | 2021-09-07 | 2023-11-03 | 浙江大为药业有限公司 | 一种高纯左亚叶酸钙的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2688018A (en) * | 1952-06-28 | 1954-08-31 | American Cyanamid Co | Method of preparing alkaline earth metal salts of 1-leucovorin |
GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
CH673459A5 (es) * | 1987-05-15 | 1990-03-15 | Eprova Ag | |
DE3821875C1 (es) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
JPH0265787A (ja) * | 1988-08-30 | 1990-03-06 | Kyowa Hakko Kogyo Co Ltd | L(‐)‐テトラヒドロ葉酸の製造法 |
CH676981A5 (es) * | 1988-11-11 | 1991-03-28 | Eprova Ag | |
DK0432441T3 (da) * | 1989-12-11 | 1996-07-29 | American Cyanamid Co | Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser |
FR2659330B1 (fr) * | 1990-03-09 | 1994-02-11 | Sapec Sa | Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. |
CH680731A5 (es) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
CH681303A5 (es) * | 1991-01-16 | 1993-02-26 | Eprova Ag |
-
1992
- 1992-02-20 IT ITMI920367A patent/IT1254635B/it active
-
1993
- 1993-02-16 KR KR1019940702846A patent/KR100256929B1/ko not_active IP Right Cessation
- 1993-02-16 AT AT93903973T patent/ATE167864T1/de not_active IP Right Cessation
- 1993-02-16 EP EP93903973A patent/EP0626965B1/en not_active Expired - Lifetime
- 1993-02-16 ES ES93903973T patent/ES2065299T1/es active Pending
- 1993-02-16 WO PCT/EP1993/000361 patent/WO1993017022A1/en active IP Right Grant
- 1993-02-16 DE DE0626965T patent/DE626965T1/de active Pending
- 1993-02-16 JP JP51450793A patent/JP3162073B2/ja not_active Expired - Lifetime
- 1993-02-16 DE DE69319420T patent/DE69319420T2/de not_active Expired - Lifetime
-
1995
- 1995-01-31 GR GR940300096T patent/GR940300096T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07506813A (ja) | 1995-07-27 |
WO1993017022A1 (en) | 1993-09-02 |
GR940300096T1 (en) | 1995-01-31 |
DE69319420T2 (de) | 1998-11-05 |
ATE167864T1 (de) | 1998-07-15 |
ITMI920367A0 (it) | 1992-02-20 |
ITMI920367A1 (it) | 1993-08-20 |
DE69319420D1 (de) | 1998-08-06 |
KR950700300A (ko) | 1995-01-16 |
IT1254635B (it) | 1995-09-28 |
JP3162073B2 (ja) | 2001-04-25 |
KR100256929B1 (ko) | 2000-05-15 |
DE626965T1 (de) | 1995-07-06 |
EP0626965B1 (en) | 1998-07-01 |
EP0626965A1 (en) | 1994-12-07 |
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