ES2065299T1 - Procedimiento para la separacion de estereoisomeros del acido folinico. - Google Patents

Procedimiento para la separacion de estereoisomeros del acido folinico.

Info

Publication number
ES2065299T1
ES2065299T1 ES93903973T ES93903973T ES2065299T1 ES 2065299 T1 ES2065299 T1 ES 2065299T1 ES 93903973 T ES93903973 T ES 93903973T ES 93903973 T ES93903973 T ES 93903973T ES 2065299 T1 ES2065299 T1 ES 2065299T1
Authority
ES
Spain
Prior art keywords
folinic acid
stereoisomers
separation
procedure
folinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES93903973T
Other languages
English (en)
Inventor
Giorgio Ripa
Rodolfo Piva
Ernst Felder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of ES2065299T1 publication Critical patent/ES2065299T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

EL ESTEREOISOMERO (6S) DE ACIDO FOLINICO SE CONTIENE DE MODO QUE TENGA UNA GRAN PUREZA OPTICA MEDIANTE LA SALIFICACION DE ACIDO FOLINICO (R, S) CON DIACION SELECTIVA POSTERIOR DE LA SAL DIASTOMERICA DESEADA.
ES93903973T 1992-02-20 1993-02-16 Procedimiento para la separacion de estereoisomeros del acido folinico. Pending ES2065299T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920367A IT1254635B (it) 1992-02-20 1992-02-20 Processo per la separazione degli stereoisomeri dell'acido folinico

Publications (1)

Publication Number Publication Date
ES2065299T1 true ES2065299T1 (es) 1995-02-16

Family

ID=11362053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93903973T Pending ES2065299T1 (es) 1992-02-20 1993-02-16 Procedimiento para la separacion de estereoisomeros del acido folinico.

Country Status (9)

Country Link
EP (1) EP0626965B1 (es)
JP (1) JP3162073B2 (es)
KR (1) KR100256929B1 (es)
AT (1) ATE167864T1 (es)
DE (2) DE69319420T2 (es)
ES (1) ES2065299T1 (es)
GR (1) GR940300096T1 (es)
IT (1) IT1254635B (es)
WO (1) WO1993017022A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
EP2502625A1 (en) * 2011-03-21 2012-09-26 GMT Fine Chemicals SA Process for the preparation of crystalline levofolinic acid
EP3461826A1 (en) 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts
EP3646873A1 (en) * 2018-10-31 2020-05-06 Aprofol AG Folate salts
KR102339433B1 (ko) * 2018-11-29 2021-12-15 주식회사 경보제약 고순도 팔로노세트론 중간체 제조 방법
CN113666931B (zh) * 2021-09-07 2023-11-03 浙江大为药业有限公司 一种高纯左亚叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (es) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (es) * 1988-11-11 1991-03-28 Eprova Ag
DE69027585T2 (de) * 1989-12-11 1997-01-16 American Cyanamid Co Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (es) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (es) * 1991-01-16 1993-02-26 Eprova Ag

Also Published As

Publication number Publication date
KR100256929B1 (ko) 2000-05-15
JPH07506813A (ja) 1995-07-27
WO1993017022A1 (en) 1993-09-02
EP0626965A1 (en) 1994-12-07
ITMI920367A1 (it) 1993-08-20
EP0626965B1 (en) 1998-07-01
JP3162073B2 (ja) 2001-04-25
ITMI920367A0 (it) 1992-02-20
ATE167864T1 (de) 1998-07-15
GR940300096T1 (en) 1995-01-31
DE626965T1 (de) 1995-07-06
DE69319420T2 (de) 1998-11-05
IT1254635B (it) 1995-09-28
DE69319420D1 (de) 1998-08-06
KR950700300A (ko) 1995-01-16

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