ES2106236T3 - Acido rs-tioctico con una morfologia nueva. - Google Patents

Acido rs-tioctico con una morfologia nueva.

Info

Publication number
ES2106236T3
ES2106236T3 ES93114669T ES93114669T ES2106236T3 ES 2106236 T3 ES2106236 T3 ES 2106236T3 ES 93114669 T ES93114669 T ES 93114669T ES 93114669 T ES93114669 T ES 93114669T ES 2106236 T3 ES2106236 T3 ES 2106236T3
Authority
ES
Spain
Prior art keywords
thioctic acid
new morphology
morphology
new
thioctic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93114669T
Other languages
English (en)
Other versions
ES2106236T5 (es
Inventor
Thomas Beisswenger
Horst Bethge
Joachim Goede
Frank Huebner
Klaus Huthmacher
Herbert Klenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6471240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2106236(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Publication of ES2106236T3 publication Critical patent/ES2106236T3/es
Application granted granted Critical
Publication of ES2106236T5 publication Critical patent/ES2106236T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBE UN ACIDO TIOCTICO RS CON MORFOLOGIA DE NUEVO TIPO, QUE PUEDE SER OBTENIDO A TRAVES DE UN PROCESO DE RECRISTALIZACION.
ES93114669T 1992-10-23 1993-09-13 Acido rs-tioctico con una morfologia nueva. Expired - Lifetime ES2106236T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235912A DE4235912C2 (de) 1992-10-23 1992-10-23 Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung
DE4235912 1992-10-23

Publications (2)

Publication Number Publication Date
ES2106236T3 true ES2106236T3 (es) 1997-11-01
ES2106236T5 ES2106236T5 (es) 2005-09-16

Family

ID=6471240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93114669T Expired - Lifetime ES2106236T5 (es) 1992-10-23 1993-09-13 Acido rs-tioctico con una morfologia nueva.

Country Status (11)

Country Link
US (1) US5455264A (es)
EP (1) EP0593896B2 (es)
JP (1) JPH06228130A (es)
AT (1) ATE157093T1 (es)
CA (1) CA2109050C (es)
DE (2) DE4235912C2 (es)
DK (1) DK0593896T4 (es)
ES (1) ES2106236T5 (es)
GR (1) GR3024746T3 (es)
IN (1) IN176618B (es)
MX (1) MX9306571A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510130C1 (de) * 1995-03-21 1996-11-21 Asta Medica Ag Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung
DE19705555A1 (de) * 1997-02-13 1998-08-20 Ulrich Dr Posanski Pharmazeutische Präparate der Thioctsäure zur oralen Anwendung
DE19726519A1 (de) * 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure
DE19810336A1 (de) * 1998-03-11 1999-09-23 Asta Medica Ag Alpha-Liponsäure mit neuartiger Modifikation
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
DE10137381A1 (de) * 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10223882A1 (de) * 2002-05-29 2003-12-18 Degussa Fliessfähige, pulverförmige Liponsäure(-Derivate) enthaltende Zusammensetzung
WO2006058278A2 (en) * 2004-11-24 2006-06-01 Hill's Pet Nutrition, Inc. Methods for improving liver clearance of xenobiotic substances in an animal
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
WO2006074089A2 (en) * 2004-12-30 2006-07-13 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
AU2009322999A1 (en) * 2008-12-01 2011-06-30 Invasc Therapeutics, Inc. Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
ITMI20111286A1 (it) 2011-07-11 2013-01-12 Laboratorio Chimico Int Spa Nuova forma cristallina
JP7203756B2 (ja) 2017-04-25 2023-01-13 イスケミックス エルエルシー 外傷性脳傷害を治療するための組成物および方法
CN107652264A (zh) * 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
CN108484570B (zh) * 2018-05-15 2021-05-04 苏州富士莱医药股份有限公司 一种制备硫辛酸颗粒的方法及设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2933430A (en) * 1959-01-22 1960-04-19 Du Pont Lipoic acid compositions
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
DE4035442B4 (de) * 1989-11-09 2010-04-29 Evonik Degussa Gmbh Arzneimittel enthaltend als Wirkstoff R-α-Liponsäure
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure

Also Published As

Publication number Publication date
MX9306571A (es) 1994-05-31
EP0593896B1 (de) 1997-08-20
DE4235912C2 (de) 2002-12-05
US5455264A (en) 1995-10-03
ATE157093T1 (de) 1997-09-15
DE59307160D1 (de) 1997-09-25
GR3024746T3 (en) 1997-12-31
JPH06228130A (ja) 1994-08-16
ES2106236T5 (es) 2005-09-16
DK0593896T4 (da) 2005-06-20
CA2109050C (en) 2002-04-23
CA2109050A1 (en) 1994-04-24
EP0593896A1 (de) 1994-04-27
DE4235912A1 (de) 1994-04-28
EP0593896B2 (de) 2005-03-02
IN176618B (es) 1996-08-10
DK0593896T3 (da) 1998-03-02

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