FR2659330B1 - Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. - Google Patents

Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.

Info

Publication number
FR2659330B1
FR2659330B1 FR9003032A FR9003032A FR2659330B1 FR 2659330 B1 FR2659330 B1 FR 2659330B1 FR 9003032 A FR9003032 A FR 9003032A FR 9003032 A FR9003032 A FR 9003032A FR 2659330 B1 FR2659330 B1 FR 2659330B1
Authority
FR
France
Prior art keywords
diastereomers
synthesis
preparation
compounds derived
tetrahydrofolic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9003032A
Other languages
English (en)
Other versions
FR2659330A1 (fr
Inventor
Fabrizio Marazza
Attilio Melera
Rene Viterbo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sapec Fine Chemicals SA
Original Assignee
Sapec Fine Chemicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9003032A priority Critical patent/FR2659330B1/fr
Application filed by Sapec Fine Chemicals SA filed Critical Sapec Fine Chemicals SA
Priority to CA002056433A priority patent/CA2056433A1/fr
Priority to EP91905831A priority patent/EP0471820A1/fr
Priority to AU74925/91A priority patent/AU7492591A/en
Priority to US07/784,422 priority patent/US5239074A/en
Priority to PCT/FR1991/000185 priority patent/WO1991013890A2/fr
Priority to JP3505789A priority patent/JPH04507103A/ja
Publication of FR2659330A1 publication Critical patent/FR2659330A1/fr
Priority to NO91914068A priority patent/NO914068L/no
Priority to FI915254A priority patent/FI915254A0/fi
Application granted granted Critical
Publication of FR2659330B1 publication Critical patent/FR2659330B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
FR9003032A 1990-03-09 1990-03-09 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. Expired - Fee Related FR2659330B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR9003032A FR2659330B1 (fr) 1990-03-09 1990-03-09 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
EP91905831A EP0471820A1 (fr) 1990-03-09 1991-03-08 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereoisomeres 6s et 6r de folates reduits
AU74925/91A AU7492591A (en) 1990-03-09 1991-03-08 Diastereoisomeric compounds derived from tetrahydrofolic acid, process for their preparation and use in the synthesis of diastereoisomers 6s and 6r of reduced folates
US07/784,422 US5239074A (en) 1990-03-09 1991-03-08 Diastereoisomeric compounds derived from tetrahydrofolic acid, process for their preparation and use in the synthesis of diastereoisomers 6s and 6r of reduced folates
CA002056433A CA2056433A1 (fr) 1990-03-09 1991-03-08 Composes diastereoisomeres derives de l'acide tetrahydrofolique; methode de preparation et utilisation pour la synthese de diastereoisomeres 6s et 6r de folates reduits
PCT/FR1991/000185 WO1991013890A2 (fr) 1990-03-09 1991-03-08 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereoisomeres 6s et 6r de folates reduits
JP3505789A JPH04507103A (ja) 1990-03-09 1991-03-08 テトラヒドロ葉酸から誘導されたジアステレオマー化合物，還元フォレートの６ｓ及び６ｒジアステレオマーの合成におけるジアステレオマー化合物の製造及び使用方法
NO91914068A NO914068L (no) 1990-03-09 1991-10-17 Diastereomere forbindelser avledet fra tetrahydrofolsyre,deres fremstilling og anvendelse ved syntese av 6s- og 6r-diastereoisomerer av reduserte folater
FI915254A FI915254A0 (fi) 1990-03-09 1991-11-07 Diastreoisomeriska, foereningar haerledda fraon tetrahydrofolsyra, ett foerfarande foer deras framstaellning samt anvaendning i syntes av 6s- och 6r-diastereoisomererna av reducerade folat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9003032A FR2659330B1 (fr) 1990-03-09 1990-03-09 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.

Publications (2)

Publication Number Publication Date
FR2659330A1 FR2659330A1 (fr) 1991-09-13
FR2659330B1 true FR2659330B1 (fr) 1994-02-11

Family

ID=9394574

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9003032A Expired - Fee Related FR2659330B1 (fr) 1990-03-09 1990-03-09 Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.

Country Status (8)

Country Link
US (1) US5239074A (fr)
EP (1) EP0471820A1 (fr)
JP (1) JPH04507103A (fr)
AU (1) AU7492591A (fr)
CA (1) CA2056433A1 (fr)
FI (1) FI915254A0 (fr)
FR (1) FR2659330B1 (fr)
WO (1) WO1991013890A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680731A5 (fr) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
NZ273161A (en) * 1993-09-14 1997-11-24 Merrell Pharma Inc 5-(1-flurovinyl)-1h-pyrimidine-2,4-dione derivatives; pharmaceutical compositions
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CN107304212A (zh) * 2016-04-21 2017-10-31 常州爱诺新睿医药技术有限公司 一种无定型l-5-甲基四氢叶酸氨基酸盐及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
DE3821875C1 (fr) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CA2021042A1 (fr) * 1989-07-21 1991-01-22 Fabrizio Marazza Sels de l'acide n,n-methylene-5,6,7,8-tetrahydrofolique

Also Published As

Publication number Publication date
CA2056433A1 (fr) 1991-09-10
WO1991013890A3 (fr) 1991-11-14
US5239074A (en) 1993-08-24
JPH04507103A (ja) 1992-12-10
EP0471820A1 (fr) 1992-02-26
FR2659330A1 (fr) 1991-09-13
AU7492591A (en) 1991-10-10
WO1991013890A2 (fr) 1991-09-19
FI915254A0 (fi) 1991-11-07

Similar Documents

Publication Publication Date Title
FR2659330B1 (fr) Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
FI890195A (fi) Foliinihapon tai sen suolojen valmistusmenetelmä
MA19858A1 (fr) Procede de preparation de derives de l'acide methylene disphosphonique .
MA21120A1 (fr) Procede de preparation de composes pharmalogiquement actifs.
IT8149676A0 (it) Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono
FR2564859B1 (fr) Procede de preparation d'acide hyaluronique par fermentation.
FR2552416B1 (fr) Procede de preparation de trifluorure d'azote par reaction gaz-solide
ES2075247T3 (es) Sales de amonio del acido n(5)-metil-5,6,7,8-tetrahidrofolico.
IT1143247B (it) Procedimento per la preparazione di sospensioni stabili e non gelificabili in particolare per la produzione di detersivi in granuli
DE3566404D1 (en) Substituted benzopyrans, process for their preparation and their use in medicines
CA2187409A1 (fr) Sels d'acide tetrahydrofolique, cristallises, stables
PT77074A (fr) Procede de preparation de nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo<3,2-a>pyrimidine et de compositions herbicides les contenant
BE882067A (fr) Derives de l'acide d-2-hydroxy-4-methylmercaptobutyrique, procede pour leur preparation et utilisation de ces composes
PT74652A (fr) Procede de preparation de derives d'imidazo <1,2-a> pyrimidines et de compositions pharmaceutiques les contenant
IE56229B1 (en) 2-piperazinyl-or-homopiperazinyl-quinazoline derivatives their production and pharmaceutical compositions containing them
FR2669643B1 (fr) Procede de synthese enzymatique d'adipate d'ammonium.
BE890649A (fr) "napsylate de (d-alpha-amino alpha-phenylacetamido)-6 penicillanate de dioxo-1, 1 penicillanoyloxymethyle cristallin et ses formes hydratees, leurs procedes de preparation et des medicaments antimicrobiens les contenant comme roduits actifs
FR2703048B1 (fr) Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
RO88451A2 (fr) Derives de l'acide 7-aminocephalosporanique et procede de preparation
FR2669330B1 (fr) Procede de preparation de l'acide betha-mercaptopropionique.
MA21305A1 (fr) Procede de preparation de l'acide (pyridyl-3)-3 ih,3h-pyrrono(i,2-c) thiazolecarboxylique-7 dextrocyre.
IT8067738A0 (it) Procedimento per la preparazione di tetraido pirrolo [1,2-a] pirimidine 3-sostituite, composizioni farmaceutiche che le contengono e tetraidro pirrolo [1,2-a] pirimidine 3-sostituite
MA22061A1 (fr) Procede pour la preparation de l'acide 7-amino-3-methoxy methyl-ceph-3-eme-4-carboxylique et son utilisation.
PT79909A (en) Process for preparing 6-substituted-5-phenyltetrazolo<1,5-a><1,2,4>tetrazolo<1,5-c>pyrimidines
MA20092A1 (fr) Procede de preparation de derives de pyrimidinetrione.

Legal Events

Date Code Title Description
ST Notification of lapse