IT1270185B - Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico - Google Patents
Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinicoInfo
- Publication number
- IT1270185B IT1270185B ITMI941193A ITMI941193A IT1270185B IT 1270185 B IT1270185 B IT 1270185B IT MI941193 A ITMI941193 A IT MI941193A IT MI941193 A ITMI941193 A IT MI941193A IT 1270185 B IT1270185 B IT 1270185B
- Authority
- IT
- Italy
- Prior art keywords
- separating
- obtaining
- folinic acid
- salts
- diastereoisomer salts
- Prior art date
Links
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title abstract 2
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 title abstract 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical class C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title abstract 2
- 235000008191 folinic acid Nutrition 0.000 title abstract 2
- 239000011672 folinic acid Substances 0.000 title abstract 2
- 229960001691 leucovorin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- -1 (6RS) -5, 10-methylene- 5, 6, 7, 8-tetrahydrofolic chloride hydrochloride Chemical compound 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
Si descrive un processo per la preparazione, la separazione e la purificazione dei diastereoisomeri (6S) e (6R) dei sali dell'acido folinico con amine almeno dibasiche che comprende l'idrolisi dell'acido (6RS)-5, 10-metenil-5, 6, 7, 8-tetraidrofolico cloruro cloridrato con una amina almeno dibasica e la successiva separazione dei sali diastereoisomeri.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941193A IT1270185B (it) | 1994-06-08 | 1994-06-08 | Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico |
DE69504189T DE69504189T2 (de) | 1994-06-08 | 1995-05-31 | Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure |
ES95921797T ES2101665T1 (es) | 1994-06-08 | 1995-05-31 | Un procedimiento para la preparacion y separacion de sales diastereonericas del acido folinico. |
PCT/EP1995/002073 WO1995033749A1 (en) | 1994-06-08 | 1995-05-31 | A process for the preparation and separation of diastereomeric salts of folinic acid |
DE0755397T DE755397T1 (de) | 1994-06-08 | 1995-05-31 | Verfahren zur herstellung und trennung von diastereomeren salzen von fölinsäure |
EP95921797A EP0755397B1 (en) | 1994-06-08 | 1995-05-31 | A process for the preparation and separation of diastereomeric salts of folinic acid |
AU26726/95A AU2672695A (en) | 1994-06-08 | 1995-05-31 | A process for the preparation and separation of diastereomeric salts of folinic acid |
JP50033096A JP4241925B2 (ja) | 1994-06-08 | 1995-05-31 | ホリニン酸のジアステレオマー塩の製造および分離法 |
AT95921797T ATE169918T1 (de) | 1994-06-08 | 1995-05-31 | Verfahren zur herstellung und trennung von diastereomeren salzen von folinsäure |
KR1019960706965A KR100262684B1 (ko) | 1994-06-08 | 1995-05-31 | 폴린산의부분입체이성질체염의제조및분리방법 |
US08/480,097 US5710271A (en) | 1994-06-08 | 1995-06-07 | Process for the preparation and separation of diastereomeric salts of folinic acid |
ZA954692A ZA954692B (en) | 1994-06-08 | 1995-06-07 | A process for the preparation and separation of diastereomeric salts of folinic acid |
IL11405095A IL114050A0 (en) | 1994-06-08 | 1995-06-07 | A process for the preparation and separation of diastereomeric salts of folinic acid |
GR970300023T GR970300023T1 (en) | 1994-06-08 | 1997-08-29 | A process for the preparation and separation of diastereomeric salts of folinic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941193A IT1270185B (it) | 1994-06-08 | 1994-06-08 | Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941193A0 ITMI941193A0 (it) | 1994-06-08 |
ITMI941193A1 ITMI941193A1 (it) | 1995-12-08 |
IT1270185B true IT1270185B (it) | 1997-04-29 |
Family
ID=11369074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941193A IT1270185B (it) | 1994-06-08 | 1994-06-08 | Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0755397B1 (it) |
JP (1) | JP4241925B2 (it) |
KR (1) | KR100262684B1 (it) |
AT (1) | ATE169918T1 (it) |
AU (1) | AU2672695A (it) |
DE (2) | DE755397T1 (it) |
ES (1) | ES2101665T1 (it) |
GR (1) | GR970300023T1 (it) |
IL (1) | IL114050A0 (it) |
IT (1) | IT1270185B (it) |
WO (1) | WO1995033749A1 (it) |
ZA (1) | ZA954692B (it) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013025203A1 (en) * | 2011-08-16 | 2013-02-21 | Watson Laboratories, Inc. | Resolution of tetrahydrofolic acid derivatives |
CN103102350A (zh) * | 2011-11-11 | 2013-05-15 | 重庆华邦胜凯制药有限公司 | 一种左亚叶酸盐的制备方法 |
CN113666931B (zh) * | 2021-09-07 | 2023-11-03 | 浙江大为药业有限公司 | 一种高纯左亚叶酸钙的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH680731A5 (it) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
DE4136921A1 (de) * | 1991-11-11 | 1993-05-13 | Knoll Ag | Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure |
IT1254635B (it) * | 1992-02-20 | 1995-09-28 | Bracco Spa | Processo per la separazione degli stereoisomeri dell'acido folinico |
-
1994
- 1994-06-08 IT ITMI941193A patent/IT1270185B/it active IP Right Grant
-
1995
- 1995-05-31 JP JP50033096A patent/JP4241925B2/ja not_active Expired - Lifetime
- 1995-05-31 AU AU26726/95A patent/AU2672695A/en not_active Abandoned
- 1995-05-31 WO PCT/EP1995/002073 patent/WO1995033749A1/en active IP Right Grant
- 1995-05-31 EP EP95921797A patent/EP0755397B1/en not_active Expired - Lifetime
- 1995-05-31 DE DE0755397T patent/DE755397T1/de active Pending
- 1995-05-31 AT AT95921797T patent/ATE169918T1/de not_active IP Right Cessation
- 1995-05-31 DE DE69504189T patent/DE69504189T2/de not_active Expired - Lifetime
- 1995-05-31 KR KR1019960706965A patent/KR100262684B1/ko active IP Right Grant
- 1995-05-31 ES ES95921797T patent/ES2101665T1/es active Pending
- 1995-06-07 IL IL11405095A patent/IL114050A0/xx not_active IP Right Cessation
- 1995-06-07 ZA ZA954692A patent/ZA954692B/xx unknown
-
1997
- 1997-08-29 GR GR970300023T patent/GR970300023T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR970300023T1 (en) | 1997-08-29 |
KR100262684B1 (ko) | 2000-08-01 |
DE69504189T2 (de) | 1998-12-24 |
ITMI941193A1 (it) | 1995-12-08 |
AU2672695A (en) | 1996-01-04 |
ES2101665T1 (es) | 1997-07-16 |
EP0755397B1 (en) | 1998-08-19 |
WO1995033749A1 (en) | 1995-12-14 |
DE755397T1 (de) | 1997-09-25 |
KR970703343A (ko) | 1997-07-03 |
ITMI941193A0 (it) | 1994-06-08 |
EP0755397A1 (en) | 1997-01-29 |
IL114050A0 (en) | 1995-10-31 |
DE69504189D1 (de) | 1998-09-24 |
JP4241925B2 (ja) | 2009-03-18 |
ZA954692B (en) | 1996-01-29 |
ATE169918T1 (de) | 1998-09-15 |
JPH10500972A (ja) | 1998-01-27 |
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Legal Events
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0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970626 |