PT100014A - Processo para a preparacao de acido (6r)-tetra-hidrofolico - Google Patents

Processo para a preparacao de acido (6r)-tetra-hidrofolico

Info

Publication number
PT100014A
PT100014A PT100014A PT10001492A PT100014A PT 100014 A PT100014 A PT 100014A PT 100014 A PT100014 A PT 100014A PT 10001492 A PT10001492 A PT 10001492A PT 100014 A PT100014 A PT 100014A
Authority
PT
Portugal
Prior art keywords
acid
tetrahydrofolic
tetrahydrofolic acid
addition salts
sulphonic
Prior art date
Application number
PT100014A
Other languages
English (en)
Other versions
PT100014B (pt
Inventor
Hans Rudolf Muller
Martin Ulmann
Josef Conti
Gunter Murdel
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova Ag filed Critical Eprova Ag
Publication of PT100014A publication Critical patent/PT100014A/pt
Publication of PT100014B publication Critical patent/PT100014B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
PT100014A 1991-01-16 1992-01-15 Processo para a preparacao de acido (6r)-tetra-hidrofolico PT100014B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH108/91A CH681303A5 (pt) 1991-01-16 1991-01-16

Publications (2)

Publication Number Publication Date
PT100014A true PT100014A (pt) 1993-03-31
PT100014B PT100014B (pt) 1999-08-31

Family

ID=4179454

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100014A PT100014B (pt) 1991-01-16 1992-01-15 Processo para a preparacao de acido (6r)-tetra-hidrofolico

Country Status (25)

Country Link
US (1) US5324836A (pt)
EP (1) EP0495204B1 (pt)
JP (1) JPH0739417B2 (pt)
KR (1) KR100207133B1 (pt)
CN (1) CN1030079C (pt)
AT (1) ATE123777T1 (pt)
AU (1) AU654993B2 (pt)
CA (1) CA2059103C (pt)
CH (1) CH681303A5 (pt)
DE (1) DE59105722D1 (pt)
DK (1) DK0495204T3 (pt)
ES (1) ES2075315T3 (pt)
FI (1) FI109906B (pt)
GE (1) GEP19971019B (pt)
HU (1) HU207083B (pt)
IE (1) IE72164B1 (pt)
IL (1) IL100478A (pt)
LV (1) LV10083B (pt)
MX (1) MX9200063A (pt)
NO (1) NO301422B1 (pt)
NZ (1) NZ241245A (pt)
PT (1) PT100014B (pt)
RU (1) RU2099340C1 (pt)
TW (1) TW198033B (pt)
ZA (1) ZA92291B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH682664A5 (en) * 1991-10-15 1993-10-29 Eprova Ag Stable salts of 5,10-methylene tetrahydrofolate.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
AU2002241918B2 (en) 2001-01-16 2007-01-18 Gr Intellectual Reserve, Llc Enhanced data storage and retrieval devices and systems and methods for utilizing the same
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
AU2003303150A1 (en) 2002-11-21 2004-07-14 Berkshire Laboratories, Inc. Enhanced data storage and retrieval devices and systems and methods for utilizing same
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
JP5925381B2 (ja) 2012-04-13 2016-05-25 ▲連雲▼港金康和信▲薬業▼有限公司Ｌｉａｎｙｕｎｇａｎｇ Ｊｉｎｋａｎｇ Ｈｅｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． 化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
CN104045640B (zh) * 2013-03-14 2016-04-06 天津康鸿医药科技发展有限公司 一种制备高纯度左亚叶酸钙的方法
CN104774169B (zh) * 2014-01-15 2017-02-15 上海韶远试剂有限公司 一种利用非手性助剂进行非对映异构体拆分的新方法
CN108164531B (zh) * 2018-02-12 2019-11-05 江苏红豆杉药业有限公司 一种l-5-甲基四氢叶酸钙的制备方法
CN112351818A (zh) 2018-07-06 2021-02-09 默克专利股份有限公司 5-甲基-(6s)-四氢叶酸和l-异亮氨酸乙酯的结晶盐

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof
DE2063027A1 (de) * 1969-12-26 1971-07-01 Yamanouchi Pharmaceutical Co Ltd , Tokio Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
JPS4832120A (pt) * 1971-08-31 1973-04-27
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (pt) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (pt) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (pt) * 1988-11-11 1991-03-28 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
DE69027585T2 (de) * 1989-12-11 1997-01-16 American Cyanamid Co Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
CH680731A5 (pt) * 1990-04-12 1992-10-30 Sapec Fine Chemicals

Also Published As

Publication number Publication date
LV10083A (lv) 1994-05-10
CN1063285A (zh) 1992-08-05
CN1030079C (zh) 1995-10-18
HUT60272A (en) 1992-08-28
HU9200134D0 (en) 1992-04-28
TW198033B (pt) 1993-01-11
NO920197D0 (no) 1992-01-15
FI920180A (fi) 1992-07-17
ZA92291B (en) 1992-09-30
RU2099340C1 (ru) 1997-12-20
GEP19971019B (en) 1997-05-22
IE72164B1 (en) 1997-03-26
NO301422B1 (no) 1997-10-27
FI109906B (fi) 2002-10-31
KR920014812A (ko) 1992-08-25
EP0495204A1 (de) 1992-07-22
US5324836A (en) 1994-06-28
NO920197L (no) 1992-07-17
LV10083B (en) 1995-04-20
ES2075315T3 (es) 1995-10-01
IL100478A0 (en) 1992-09-06
JPH04312586A (ja) 1992-11-04
KR100207133B1 (ko) 1999-07-15
MX9200063A (es) 1993-01-01
CA2059103C (en) 1996-12-17
EP0495204B1 (de) 1995-06-14
CA2059103A1 (en) 1992-07-17
IE920112A1 (en) 1992-07-29
HU207083B (en) 1993-03-01
AU654993B2 (en) 1994-12-01
DE59105722D1 (de) 1995-07-20
CH681303A5 (pt) 1993-02-26
DK0495204T3 (da) 1995-08-07
IL100478A (en) 1999-03-12
NZ241245A (en) 1993-11-25
ATE123777T1 (de) 1995-06-15
AU1025492A (en) 1992-07-23
JPH0739417B2 (ja) 1995-05-01
FI920180A0 (fi) 1992-01-15
PT100014B (pt) 1999-08-31

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Legal Events

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BB1A Laying open of patent application

Effective date: 19920917

FG3A Patent granted, date of granting

Effective date: 19990503

PC4A Transfer of assignment

Owner name: MERCK & CIE, CH

Effective date: 20120531

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20140505